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Boraginaceae

Boraginaceae (31):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-N6012
    (-)-Alkannin 517-88-4 99.58%
    (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway.
    (-)-Alkannin
  • HY-N5112B
    β,β-Dimethylacrylshikonin 24502-79-2 99.64%
    β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity.
    β,β-Dimethylacrylshikonin
  • HY-N7610
    Acetylalkannin 34232-27-4 99.85%
    Acetylalkannin (Alkannin acetate) is an isohexenylnaphthazarin pigment isolated from Arnebia euchroma with antimicrobial and cytotoxic activities.
    Acetylalkannin
  • HY-N4201
    β-Hydroxyisovalerylshikonin 7415-78-3 99.83%
    Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.
    β-Hydroxyisovalerylshikonin
  • HY-113845R
    (+)-Intermedine (Standard) 10285-06-0
    (+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
    (+)-Intermedine (Standard)
  • HY-121286
    Echinatine 480-83-1
    Echinatine is an active compound. Echinatine can be derived from C. barrelieri. C. barrelieri exhibits strong antioxidant activity.
    Echinatine
  • HY-122931
    Supinine 551-58-6
    Supinine is an alkaloid. Supinine can be isolated from Heliotropium europaeum.
    Supinine
  • HY-113845
    (+)-Intermedine 10285-06-0 ≥99.0%
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
    (+)-Intermedine
  • HY-N2592
    Isobutylshikonin 52438-12-7 99.53%
    Isobutylshikonin is a kind of shikonin pigments from hairy root culture of Lithospermum canescens.
    Isobutylshikonin
  • HY-N5112
    (Rac)-Arnebin 1 5162-01-6 99.36%
    (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity.
    (Rac)-Arnebin 1
  • HY-105529
    Indicine N-oxide 41708-76-3
    Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research.
    Indicine N-oxide
  • HY-121390
    Lasiocarpine 303-34-4
    Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.
    Lasiocarpine
  • HY-124140
    Heliosupine 32728-78-2
    Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.
    Heliosupine
  • HY-131574
    Heliosupine N-oxide 31701-88-9
    Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA).
    Heliosupine N-oxide
  • HY-131578
    Rinderine N-oxide 137821-16-0
    Rinderine N-oxide is a pyrrolizidine alkaloid that can be found in R. graeca.
    Rinderine N-oxide
  • HY-136486
    Lasiocarpine N-oxide 127-30-0
    Lasiocarpine N-oxide is a natural compound with antitumor activity.
    Lasiocarpine N-oxide
  • HY-N10589
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone 1562996-11-5
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone, an angular-type pyranocoumarin is a natural product that can be isolated from Peucedani Radix. .
    (+)-trans-3'-Acetyl-4'-isobutyrylkhellactone
  • HY-N11891
    4-(β-D-glucopyranosyloxy)benzoic acid 15397-25-8
    4-(β-D-glucopyranosyloxy)benzoic acid is a phenolic glucoside can be isolated from fennel seeds.
    4-(β-D-glucopyranosyloxy)benzoic acid
  • HY-N144101
    SARS-CoV MPro-IN-2 81418-42-0
    SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19.
    SARS-CoV MPro-IN-2