9''-Methyl lithospermic acid
9''-Methyl lithospermic acid is a serine palmitoyltransferase (SPT) activator. 9''-Methyl lithospermic acid increases the levels of SPT1 and SPT2 in human keratinocytes. 9''-Methyl lithospermic acid maintains epidermal permeability barrier function by promoting SPT expression.
For research use only. We do not sell to patients.
- CAS No.: 1151683-53-2
- Formula: C28H24O12
- Molecular Weight:552.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
9''-Methyl lithospermic acid (Compound 2) (100 μg/mL) significantly increases SPT1 mRNA (to 139%) and SPT2 mRNA (to 139%) expression in normal human keratinocyte HaCaT cells[1].
9''-Methyl lithospermic acid (10-100 μg/mL; 9 h) dose-dependently increases SPT protein expression in normal human keratinocyte HaCaT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT
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Concentration:10 μg/mL, 30 μg/mL, 100 μg/mL
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Incubation Time:9 h
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Result:Increased SPT protein levels to 108.9% of negative control at 10 μg/mL.
Increased SPT protein levels to 120.2% of negative control at 30 μg/mL.
Increased SPT protein levels to 123% of negative control at 100 μg/mL, showing a dose-dependent effect.
Chemical Information
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CAS No. 1151683-53-2
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Molecular Weight 552.48
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Formula C28H24O12
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SMILES
OC([C@H]1C2=C(/C=C/C(O[C@@H](C(OC)=O)CC3=CC(O)=C(C=C3)O)=O)C=CC(O)=C2O[C@@H]1C4=CC(O)=C(C=C4)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
9''-Methyl lithospermic acid Related Classifications
HY-N20677 Related Classifications
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