1607436-76-9
Chemical Structure
Monardic acid A
- CAS No.: 1607436-76-9
- Formula:C27H22O12
- Molecular Weight:538.46
InChIKey: UJZQBMQZMKFSRV-PHQFMFTGSA-N
SMILES: OC([C@@H]1C2=C(/C=C/C(O[C@@H](C(O)=O)CC3=CC(O)=C(C=C3)O)=O)C=CC(O)=C2O[C@H]1C4=CC(O)=C(C=C4)O)=O
Biological Activity: Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases[1][2].
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Monardic acid A | Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Krzyżanowska-Kowalczyk J, et al. Novel Phenolic Constituents of Pulmonaria officinalis L. LC-MS/MS Comparison of Spring and Autumn Metabolite Profiles. Molecules. 2018 Sep 6;23(9):2277. [Content Brief]
- [2]. Odonbayar B, et al. Chemical constituents of aerial parts of Thymus gobicus and their cholinesterase inhibitory activities[J]. Mongolian Journal of Chemistry, 2016, 17(43): 14-17.
