2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Src
  5. SRC-3 Isoform

SRC-3

SRC-3/NCOA3/AIB1 is a p160 nuclear receptor coactivator that bridges nuclear receptors and transcription factors to chromatin-regulating coactivator complexes, thereby supporting transcriptional activation[1]. Mechanistically, SRC-3 regulates ERα, AP-1, E2F, NF-κB, and TEAD-dependent gene programs, linking hormone signaling, inflammatory transcription, proliferation, and oncogenic gene expression[1][2]. In breast cancer models, SRC-3 promotes ERα-positive tumor biology, endocrine resistance, and XBP1-associated unfolded protein response signaling through the PERK-ATF4 pathway[3][4]. Compared with related p160 isoforms, NCOA3 shows selective recruitment to the PLAC1 promoter in ERα-positive MCF-7 cells, whereas NCOA1 and NCOA2 do not show this recruitment pattern[5]. In stem-cell models, Ncoa3 also acts as an essential Esrrb coactivator that sustains embryonic stem-cell self-renewal and reprogramming[6]. For experimental applications, SRC-3 inhibition by bufalin reduced TNBC cell viability and motility, while 3-phospho-bufalin inhibited tumor growth in an orthotopic TNBC mouse model[7].

SRC-3 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-176225
    BY13
    		Degrader
    BY13 is a SRC-3 PROTAC degrader with a DC50 of 0.031 μM. BY13 selectively blocks the ER signaling pathway over that of androgen receptor (AR)) through down-regulating ERα level. BY13 potently overcomes endocrine resistance in breast cancer by inducing cell cycle arrest in G1 phase and apoptosis, with superior effect over Fulvestrant (HY-13636). BY13 significantly inhibits the growth of drug-resistant breast tumors without obvious toxicity in LCC2 xenograft mice model. Pink: SRC-3 ligand (SI-2) (HY-101447); Blue: CRBN ligase ligand (HY-41547); Black: linker (HY-176226)