223788-33-8
Chemical Structure
SI-2
Synonym(s): EPH 116
- CAS No.: 223788-33-8
- Formula:C15H15N5
- Molecular Weight:265.31
IUPAC Name: (E)-1-methyl-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1H-benzo[d]imidazole
InChIKey: JNNXERNBPXXNLK-WOJGMQOQSA-N
SMILES: CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13
Biological Activity: SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg)[1].
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SI-2 | SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg). | |||||||||||||||||||||
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Keywords
