1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. ErbB2/HER2 Inhibitors

ErbB2/HER2 Inhibitors

EGFR/ErbB1/HER1

ErbB2/HER2

ErbB3/HER3

ErbB4/HER4

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Sorry. There is currently no product that acts on isoform ErbB2/HER2 together.

Please try each isoform separately.

ErbB2/HER2 Specific Inhibitors
Product Name ErbB2/HER2 EGFR/ErbB1/HER1 ErbB3/HER3 ErbB4/HER4 ErbB2/HER2 Selectivity Purity
Mubritinib
HER2, IC50: 6 nM
      Selective Inhibitor 99.97%
PD158780
ErbB2, IC50: 49 nM (Cell Assay)
EGFR, IC50: 8 μM (Cell Assay)
ErbB3, IC50: 52 nM (Cell Assay)
ErbB4, IC50: 52 nM (Cell Assay)
Selective Inhibitor 98.04%
CP-724714
ErbB2, IC50: 10 nM
      Selective Inhibitor 99.62%
AV-412
ErbB2, IC50: 19 nM
EGFR, IC50: 0.75 nM
EGFRL858R, IC50: 0.5 nM
EGFRT790M, IC50: 0.79 nM
EGFRL858R/T790M, IC50: 2.3 nM
    Selective Inhibitor 99.26%
TAS0728
HER2, IC50: 13 nM
Human HER2, IC50: 36 nM
EGFR, IC50: 65 nM
 
HER4, IC50: 8.5 nM
Pan Inhibitor
Sapitinib
ErbB2, IC50: 3 nM
EGFR, IC50: 4 nM
HER3, IC50: 4 nM
  Pan Inhibitor 99.99%
Pyrotinib
HER2, IC50: 38 nM
EGFR, IC50: 13 nM
    Pan Inhibitor 98.84%
BMS-690514
HER2, IC50: 20 nM
EGFR, IC50: 5 nM
 
HER4, IC50: 60 nM
Pan Inhibitor 99.37%
Canertinib dihydrochloride
ErbB2, IC50: 9 nM
EGFR, IC50: 7.4 nM
    Pan Inhibitor 98.51%
Afatinib dimaleate
HER2, IC50: 14 nM
EGFR, IC50: 0.5 nM
EGFRL858R, IC50: 0.4 nM
EGFRL858R/T790M, IC50: 10 nM
    Pan Inhibitor 99.31%
Varlitinib
HER2, IC50: 2 nM
HER1, IC50: 7 nM
 
HER4, IC50: 4 nM
Pan Inhibitor >98.0%
Tesevatinib
ErbB2, IC50: 16 nM
EGFR, IC50: 0.3 nM
    Pan Inhibitor 99.21%
CUDC-101
HER2, IC50: 15.7 nM
EGFR, IC50: 2.4 nM
    Pan Inhibitor 99.59%
AEE788
ErbB2, IC50: 6 nM
EGFR, IC50: 2 nM
    Pan Inhibitor 99.91%
tarloxotinib bromide
EGFR/HER2
      Pan Inhibitor 98.97%
Canertinib
ErbB2, IC50: 9 nM
EGFR, IC50: 7.4 nM
    Pan Inhibitor 99.10%
TAK-285
HER2, IC50: 17 nM
EGFR, IC50: 23 nM
    Pan Inhibitor 99.16%
Allitinib tosylate
ErbB2, IC50: 3 nM
EGFR, IC50: 0.5 nM
    Pan Inhibitor 99.23%
AV-412 free base
ErbB2, IC50: 19 nM
EGFR, IC50: 0.75 nM
EGFRL858R, IC50: 0.51 nM
EGFRL858R/T790M, IC50: 2.3 nM
EGFRT790M, IC50: 0.79 nM
    Pan Inhibitor 98.49%
Pyrotinib dimaleate
HER2, IC50: 38 nM
EGFR, IC50: 13 nM
    Pan Inhibitor 98.60%
Epertinib
HER2, IC50: 2.49 nM
EGFR, IC50: 1.48 nM
 
HER4, IC50: 7.15 nM
Pan Inhibitor >98.0%
Tyrphostin AG 528
ErbB2, IC50: 2.1 μM
EGFR, IC50: 4.9 μM
    Pan Inhibitor >98.0%
BGB-102
HER2, IC50: 18 nM
EGFR, IC50: 9.6 nM
 
HER4, IC50: 40.3 nM
Pan Inhibitor
Allitinib
ErbB2, IC50: 3 nM
EGFR, IC50: 0.5 nM
EGFRL858R/T790M, IC50: 12 nM
    Pan Inhibitor