1. Signaling Pathways
  2. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  3. EGFR
  4. ErbB2/HER2 Inhibitors

ErbB2/HER2 Inhibitors

EGFR/ErbB1/HER1

ErbB2/HER2

ErbB3/HER3

ErbB4/HER4

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Sorry. There is currently no product that acts on isoform ErbB2/HER2 together.

Please try each isoform separately.

ErbB2/HER2 Specific Inhibitors
Product Name ErbB2/HER2 EGFR/ErbB1/HER1 ErbB3/HER3 ErbB4/HER4 ErbB2/HER2 Selectivity Purity
Trastuzumab
HER2
      Selective Inhibitor 99.80%
Tucatinib
HER2
      Selective Inhibitor ≥99.0%
Pertuzumab
HER2
      Selective Inhibitor ≥99.1%
Mubritinib
HER2, IC50: 6 nM
      Selective Inhibitor 99.97%
Mobocertinib succinate
HER2
EGFR exon 20 insertion
    Selective Inhibitor 99.61%
CP-724714
ErbB2, IC50: 10 nM
      Selective Inhibitor 99.33%
AG-825
ErbB2, IC50: 0.35 μM
EGFR, IC50: 19 μM
    Selective Inhibitor 98.07%
(E/Z)-CP-724714
HER2
      Selective Inhibitor
EGFR/ErbB-2/ErbB-4 inhibitor-2
ErbB2, IC50: 0.08 μM
EGFR, IC50: 0.017 μM
 
ErbB4, IC50: 1.91 μM
Pan Inhibitor 99.69%
Afatinib
HER2, IC50: 14 nM
EGFR, IC50: 0.5 nM
EGFRL858R, IC50: 0.4 nM
EGFRL858R/T790M, IC50: 10 nM
    Pan Inhibitor 99.99%
Lapatinib
ErbB2, IC50: 9.8 nM (Cell Free Assay)
EGFR, IC50: 10.2 nM (Cell Free Assay)
    Pan Inhibitor 99.83%
Neratinib
HER2, IC50: 59 nM
EGFR, IC50: 92 nM
    Pan Inhibitor ≥98.0%
Dacomitinib
ErbB2, IC50: 45.7 nM
EGFR, IC50: 6 nM
 
ErbB4, IC50: 73.7 nM
Pan Inhibitor ≥95.0%
Sapitinib
ErbB2, IC50: 3 nM
EGFR, IC50: 4 nM
HER3, IC50: 4 nM
  Pan Inhibitor 99.99%
Pyrotinib
HER2, IC50: 38 nM
EGFR, IC50: 13 nM
    Pan Inhibitor 99.61%
Afatinib dimaleate
HER2, IC50: 14 nM
EGFR, IC50: 0.5 nM
EGFRL858R, IC50: 0.4 nM
EGFRL858R/T790M, IC50: 10 nM
    Pan Inhibitor ≥95.0%
CUDC-101
HER2, IC50: 15.7 nM
EGFR, IC50: 2.4 nM
    Pan Inhibitor 99.19%
Lapatinib ditosylate
ErbB2, IC50: 9.2 nM (Cell Free Assay)
EGFR, IC50: 10.8 nM (Cell Free Assay)
    Pan Inhibitor ≥98.0%
Pyrotinib dimaleate
HER2, IC50: 38 nM
EGFR, IC50: 13 nM
    Pan Inhibitor 99.63%
BMS-690514
HER2, IC50: 20 nM
EGFR, IC50: 5 nM
 
HER4, IC50: 60 nM
Pan Inhibitor 99.89%
Canertinib
ErbB2, IC50: 9 nM
EGFR, IC50: 7.4 nM
    Pan Inhibitor 99.82%
TAS0728
HER2, IC50: 13 nM
Human HER2, IC50: 36 nM
EGFR, IC50: 65 nM
 
HER4, IC50: 8.5 nM
Pan Inhibitor 99.53%
Canertinib dihydrochloride
ErbB2, IC50: 9 nM
EGFR, IC50: 7.4 nM
    Pan Inhibitor ≥98.0%
TAK-285
HER2, IC50: 17 nM
EGFR, IC50: 23 nM
    Pan Inhibitor ≥95.0%
Tesevatinib
ErbB2, IC50: 16 nM
EGFR, IC50: 0.3 nM
    Pan Inhibitor ≥98.0%
AEE788
ErbB2, IC50: 6 nM
EGFR, IC50: 2 nM
    Pan Inhibitor ≥98.0%
BDTX-189
HER2, Kd: 0.76 nM
EGFR, Kd: 0.2 nM
    Pan Inhibitor 99.94%
Varlitinib
HER2, IC50: 2 nM
HER1, IC50: 7 nM
 
HER4, IC50: 4 nM
Pan Inhibitor ≥98.0%
Tarloxotinib bromide
EGFR/HER2
      Pan Inhibitor 98.97%
PD158780
ErbB2, IC50: 49 nM (Cell Assay)
EGFR, IC50: 8 μM (Cell Assay)
ErbB3, IC50: 52 nM (Cell Assay)
ErbB4, IC50: 52 nM (Cell Assay)
Pan Inhibitor 99.52%
AV-412
ErbB2, IC50: 19 nM
EGFR, IC50: 0.75 nM
EGFRL858R, IC50: 0.5 nM
EGFRT790M, IC50: 0.79 nM
EGFRL858R/T790M, IC50: 2.3 nM
    Pan Inhibitor 99.17%
Allitinib tosylate
ErbB2, IC50: 3 nM
EGFR, IC50: 0.5 nM
EGFRL858R/T790M, IC50: 12 nM
 
ErbB4, IC50: 0.8 nM
Pan Inhibitor 99.23%
Epertinib hydrochloride
HER2, IC50: 7.15 nM
EGFR, IC50: 1.48 nM
 
HER4, IC50: 2.49 nM
Pan Inhibitor 99.76%
Tyrphostin AG 528
ErbB2, IC50: 2.1 μM
EGFR, IC50: 4.9 μM
    Pan Inhibitor ≥98.0%
AV-412 free base
ErbB2, IC50: 19 nM
EGFR, IC50: 0.75 nM
EGFRL858R, IC50: 0.51 nM
EGFRL858R/T790M, IC50: 2.3 nM
EGFRT790M, IC50: 0.79 nM
    Pan Inhibitor 98.07%
Falnidamol
ErbB2, IC50: 3.4 μM
EGFR, IC50: 3 nM
    Pan Inhibitor 98.07%
Epertinib
HER2, IC50: 2.49 nM
EGFR, IC50: 1.48 nM
 
HER4, IC50: 7.15 nM
Pan Inhibitor ≥98.0%
CHMFL-EGFR-202
ErbB2, IC50: 8.1 nM
EGFRT790M, IC50: 5.3 nM
EGFR, IC50: 8.3 nM
 
ErbB4, IC50: 3.2 nM
Pan Inhibitor
SU5204
HER2, IC50: 51.5 μM
      Pan Inhibitor 98.89%
HKI-357
ErbB2, IC50: 33 nM
EGFR, IC50: 34 nM
    Pan Inhibitor ≥99.0%
Allitinib
ErbB2, IC50: 3 nM
EGFR, IC50: 0.5 nM
EGFRL858R/T790M, IC50: 12 nM
 
ErbB4, IC50: 0.8 nM
Pan Inhibitor