Zanidatamab
Based on 1 publication(s) in Google Scholar
Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity.
For research use only. We do not sell to patients.
- Purity: 98.56%
- CAS No.: 2169946-15-8
- Molecular Weight:124.65kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Zanidatamab
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
All EGFR Isoforms
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Biological Activity
half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
Human
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HER2 |
Zanidatamab (ZW25) has low nM binding affinity (0.9-16 nM) to recombinant HER2 and to cultured cancer cells with a range of HER2 expression[1].
Zanidatamab inhibits the growth of human cancer cell lines with a wide range of HER2 expression (5-54% inhibition depending on the cell line), and inhibits ligand-mediated tumor cell proliferation[1].
Zanidatamab elicits concentration-dependent ADCC at nM potency (0.05-64 nM) with maximal lysis up to 52% on TNBC cell lines expressing HER2 and exhibits synergy and additivity with multiple chemotherapeutic agents including platins, taxanes, microtubule inhibitors, and DNA synthesis inhibitors in various HER2 expressing tumor cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
ELISA, FACS, Functional assay
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Loaded Zanidatamab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (S310Y, HEK293, His, HY-P78680) with an affinity constant of 7.956E-11 M as determined in BLI assay. -
Immobilized Zanidatamab can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC50 for this effect is 3.09 ng/mL.
Chemical Information
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CAS No. 2169946-15-8
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Appearance Liquid
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Molecular Weight 124.65kDa
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Color Colorless to light yellow
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SMILES
[Zanidatamab]
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Synonyms
ZW 25; ZW-49 Antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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MAbs
Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo. [Abstract]2024 Jan-Dec;16(1):2412881. PMID: 39381966
Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]
Head-to-head comparison of KJ015, Zanidatamab (0.01-100 μg/mL, 120 h), and Anbenitamab in MDA-MB-175. All assays were repeated twice.
Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]
Immunoblots of cell lysates from SK-Br-3 and NCI-N87 cells treated with IgG, Trastuzumab, Pertuzumab, tras+pert, or KJ015 at a final concentration of 50 nM for 24 h. Extra groups of anbenitamab and zanidatamab were added at the same concentration in MDA-MB-175 cells. Actin served as the loading control. T: trastuzumab, P: pertuzumab, T+P: tras+pert, Anbe: anbenitamab, Zani: zanidatamab.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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