1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Deruxtecan

Deruxtecan 

Cat. No.: HY-13631E Purity: 98.06% ee.: 100%
Handling Instructions

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

For research use only. We do not sell to patients.

Deruxtecan Chemical Structure

Deruxtecan Chemical Structure

CAS No. : 1599440-13-7

Size Price Stock
5 mg USD 752 Ask For Quote & Lead Time
10 mg USD 1200 Ask For Quote & Lead Time
50 mg USD 3600 Ask For Quote & Lead Time
100 mg USD 5760 Ask For Quote & Lead Time

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Other Forms of Deruxtecan:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

IC50 & Target

Camptothecins

 

In Vitro

Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1034.05

Formula

C52H56FN9O13

CAS No.
SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[[email protected]@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[[email protected]@H]3C4=C5C(C(N6C5)=CC([[email protected]](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (33.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9671 mL 4.8354 mL 9.6707 mL
5 mM 0.1934 mL 0.9671 mL 1.9341 mL
10 mM 0.0967 mL 0.4835 mL 0.9671 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.75 mg/mL (1.69 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.75 mg/mL (1.69 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.75 mg/mL (1.69 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.43%

References
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Product Name:
Deruxtecan
Cat. No.:
HY-13631E
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