1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Deruxtecan

Deruxtecan 

Cat. No.: HY-13631E Purity: 99.43%
Handling Instructions

Deruxtecan, a toxin (DNA Topoisomerase I inhibitor) and linker moiety of DS-8201, is a drug-linker conjugate for antibody-drug conjugate (ADC) extracted from patent WO2017002776A1, compound 1.

For research use only. We do not sell to patients.

Deruxtecan Chemical Structure

Deruxtecan Chemical Structure

CAS No. : 1599440-13-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 2218 In-stock
Estimated Time of Arrival: December 31
1 mg USD 750 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Deruxtecan:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

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Description

Deruxtecan, a toxin (DNA Topoisomerase I inhibitor) and linker moiety of DS-8201, is a drug-linker conjugate for antibody-drug conjugate (ADC) extracted from patent WO2017002776A1, compound 1.

IC50 & Target

Camptothecins

 

In Vitro

Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window[2].

Clinical Trial
Molecular Weight

1034.05

Formula

C₅₂H₅₆FN₉O₁₃

CAS No.

1599440-13-7

SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[[email protected]@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[[email protected]@H]3C4=C5C(C(N6C5)=CC([[email protected]](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (48.35 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9671 mL 4.8354 mL 9.6707 mL
5 mM 0.1934 mL 0.9671 mL 1.9341 mL
10 mM 0.0967 mL 0.4835 mL 0.9671 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.43%

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Deruxtecan
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HY-13631E
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