2. Others Antibody-drug Conjugate/ADC Related
  3. Isotope-Labeled Compounds Drug-Linker Conjugates for ADC
  4. Deruxtecan-d5

Deruxtecan-d5  (Synonyms: MC-GGFG-DXD-d5)

Cat. No.: HY-13631ES4 Purity: 98.40%
COA
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Handling Instructions Technical Support

Deruxtecan-d5 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

For research use only. We do not sell to patients.

Deruxtecan-d<sub>5</sub>

Deruxtecan-d5 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg In-stock
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100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Deruxtecan-d5:

Deruxtecan-d5 Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Deruxtecan-d5 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deruxtecan-d5 Related Antibodies
Molecular Weight

1039.08

Formula

C52H51D5FN9O13
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)C([2H])([2H])C([2H])([2H])[2H])=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (96.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9624 mL 4.8119 mL 9.6239 mL
5 mM 0.1925 mL 0.9624 mL 1.9248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9624 mL 4.8119 mL 9.6239 mL 24.0597 mL
5 mM 0.1925 mL 0.9624 mL 1.9248 mL 4.8119 mL
10 mM 0.0962 mL 0.4812 mL 0.9624 mL 2.4060 mL
15 mM 0.0642 mL 0.3208 mL 0.6416 mL 1.6040 mL
20 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2030 mL
25 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9624 mL
30 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8020 mL
40 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6015 mL
50 mM 0.0192 mL 0.0962 mL 0.1925 mL 0.4812 mL
60 mM 0.0160 mL 0.0802 mL 0.1604 mL 0.4010 mL
80 mM 0.0120 mL 0.0601 mL 0.1203 mL 0.3007 mL
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Deruxtecan-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deruxtecan-d5MC-GGFG-DXD-d5Isotope-Labeled CompoundsDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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