Trastuzumab deruxtecan
Based on 9 publication(s) in Google Scholar
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 1826843-81-5
- Molecular Weight:153000 (average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Trastuzumab deruxtecan
More- Cancer Discov. 2026 Apr 2. [Abstract]
- Mol Cancer Ther. 2026 Mar 26. [Abstract]
- Sci Rep. 2026 May 7. [Abstract]
- Cancers (Basel). 2026 Mar 19;18(6):997. [Abstract]
- Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
- bioRxiv. 2026 Jun 19.
- bioRxiv. 2026 May 27.
- Saint Joseph University. 2026.
- Biomed Pharmacother. 2023 Jul:163:114751. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
All EGFR Isoforms
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Biological Activity
Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[2].
Trastuzumab deruxtecan (10 nM; 5 days) shows bystander killing effects in HER2-negative MDA-MB-468 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1826843-81-5
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Appearance Solid
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Molecular Weight 153000 (average)
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Color White to off-white
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SMILES
[Trastuzumab deruxtecan]
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Synonyms
T-DXd; DS-8201; DS-8201a
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Cancer Discov
HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies. [Abstract]2026 Apr 2. PMID: 41925564 -
Mol Cancer Ther
Antibody-drug-conjugates prepared with Peptide Asparaginyl Ligases achieve strong in vitro and in vivo anti-tumor activity. [Abstract]2026 Mar 26. PMID: 41889275 -
Sci Rep
Expression of HER2 in the eye and the potential for on-target side effects with antibody-drug conjugates. [Abstract]2026 May 7. PMID: 42098228 -
Cancers (Basel)
Characterization of HER2-Positive Murine Breast Cancer Models for Investigating HER2-Targeted Therapy and Immunotherapy. [Abstract]2026 Mar 19;18(6):997. PMID: 41899598 -
Biochem Biophys Res Commun
3D layered co-culture model enhances Trastuzumab Deruxtecan sensitivity and reveals the combined effect with G007-LK in HER2-positive non-small cell lung cancer. [Abstract]2024 Sep 17:725:150255. PMID: 38897043
Trastuzumab deruxtecan purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
Trastuzumab deruxtecan (1 μg/mL; 120 h). H2170 was treated with the indicated drugs and concentrations. Cell viability was measured by CellTiter-Glo assay or ONE-Glo Luciferase Assay.
Trastuzumab deruxtecan purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
Trastuzumab deruxtecan (0-10 μg/mL; 72 h). JFCR-007 Luc-ZsG-positive cells were treated with T-DXd for 72 h in each co-culture conditions. Cell viability was measured by ONE-Glo Luciferase Assay.
Trastuzumab deruxtecan purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
Trastuzumab deruxtecan (0-10 μg/mL; 120 h). The indicated cells were treated with serially diluted T-DXd for 120 h in a 2D culture condition.
Trastuzumab deruxtecan purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
JFCR-007 was treated with or without T-DXd (10 μg/mL) for 120 h in spheroid condition.
Trastuzumab deruxtecan purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Sep 17:725:150255. [Abstract]
Trastuzumab deruxtecan (1 μg/mL; 120 h). JFCR-007 was treated with the indicated drugs and concentrations. Cell viability was measured by CellTiter-Glo assay or ONE-Glo Luciferase Assay.
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Biomed Pharmacother
Patient-derived organoid culture of gastric cancer for disease modeling and drug sensitivity testing. [Abstract]2023 Jul:163:114751. PMID: 37105073
Solvent & Solubility
H2O : ≥ 20 mg/mL
* "≥" means soluble, but saturation unknown.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Kumagai K, et al. Interstitial pneumonitis related to trastuzumab deruxtecan, a human epidermal growth factor receptor 2-targeting Ab-drug conjugate, in monkeys. Cancer Sci. 2020 Dec;111(12):4636-4645. [Content Brief]
[2]. Kotani D, et, al. Trastuzumab deruxtecan for the treatment of patients with HER2-positive gastric cancer. Ther Adv Med Oncol. 2021 Jan 7;13:1758835920986518. [Content Brief]
[3]. Ogitani Y, et, al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46. [Content Brief]
[4]. Iwata TN, et, al. [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model. PLoS One. 2019 Oct 1;14(10):e0222280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trastuzumab deruxtecan Related Classifications
HY-138298A Related Classifications
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