2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Trastuzumab emtansine

Trastuzumab emtansine  (Synonyms: Ado-Trastuzumab emtansine; PRO132365; T-DM 1)

Cat. No.: HY-P9921 Purity: 98.54%
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer.

For research use only. We do not sell to patients.

CAS No. : 1018448-65-1

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Based on 6 publication(s) in Google Scholar

Other Forms of Trastuzumab emtansine:

Trastuzumab emtansine Related Antibodies

Top Publications Citing Use of Products

    Trastuzumab emtansine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 0.001-10 nM; 5 days). In vitro evaluation of ADCs. Proliferation inhibitory activity of ADCs against NCI‐N87 (HER2+) cells. Tumor cells were treated with ADCs for 5 days and relative cell viability (%) was calculated.

    Trastuzumab emtansine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). The tumor volume change of bystander killing in co-inoculation xenograft model following a single intravenous ADC dose of 2 or 5 mg/kg.

    Trastuzumab emtansine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). Bystander killing in co-inoculation xenograft model following a single intravenous ADC dose of 2 or 5 mg/kg. Bioluminescence imaging data of luciferase activity.

    Trastuzumab emtansine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). HER2 expression on tumors consisting of either HER2‐positive or HER2‐negative cells, co‐inoculation (2: 5 ratio at the time of implantation) and the remaining and regrown tumors after treatment with each ADC.

    Trastuzumab emtansine purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Sep 8;16(9):1189.

    FACS analysis of ET-NK/T-DM1. ED-TM at 20 μg was added to NK cells to prepare ET-NK cells for 12 h at 37 ℃ and 5% CO2. The ET-NK cells were mixed with T-DM1 at 20 μg for 15 min at room temperature, resulting in the formation of ET-NK/T-DM1. ED-TM and T-DM1 were conjugated with rhodamine and FITC, respectively. Fluorescence on the ET-NK/T-DM1 was observed using CLSM. ED-TM: cell surface engineering fusion protein; T-DM1: trastuzumab emtansine; ET-NK: NK cell modified by ED-TM; ET-NK/T-DM1: ET-NK cell incorporated with T-DM1; FITC: fluorescein; CLSM: confocal laser scanning microscopy.

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    Description

    Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].

    In Vitro

    Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Trastuzumab emtansine Related Antibodies
    In Vivo

    Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: CB-17/SCID mice (6 weeks) were injected with OVA10 cells[2]
    Dosage: 15 mg/kg
    Administration: I.v. three to five times weekly for 3 weeks
    Result: Showed remarkable inhibition of tumor growth in mice and was well tolerated.
    Molecular Weight

    148000 (average)

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Trastuzumab emtansine]
    Shipping

    Shipping with dry ice.
    Storage

    -80°C, protect from light
    Purity & Documentation

    Purity: 99.74%

    SDS (251 KB)

    COA (292 KB)

    Handling Instructions (2659 KB)
    References
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    Trastuzumab emtansine Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trastuzumab emtansine1018448-65-1Ado-Trastuzumab emtansine PRO132365 T-DM 1PRO132365PRO 132365PRO-132365Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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