1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. Trastuzumab emtansine

Trastuzumab emtansine (Synonyms: Ado-Trastuzumab emtansine; PRO132365; T-DM 1)

Cat. No.: HY-P9921
Handling Instructions

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer.

For research use only. We do not sell to patients.

Trastuzumab emtansine Chemical Structure

Trastuzumab emtansine Chemical Structure

CAS No. : 1018448-65-1

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5 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
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Description

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].

In Vitro

Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB-17/SCID mice (6 weeks) were injected with OVA10 cells[2]
Dosage: 15 mg/kg
Administration: I.v. three to five times weekly for 3 weeks
Result: Showed remarkable inhibition of tumor growth in mice and was well tolerated.
CAS No.

1018448-65-1

SMILES

[Trastuzumab emtansine]

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Keywords:

Trastuzumab emtansineAdo-Trastuzumab emtansine PRO132365 T-DM 1PRO132365PRO 132365PRO-132365ADC CytotoxinInhibitorinhibitorinhibit

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Trastuzumab emtansine
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HY-P9921
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