2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. EGFR Antibody-Drug Conjugates (ADCs)
  4. Trastuzumab emtansine (solution)

Trastuzumab emtansine (solution)  (Synonyms: Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution))

Cat. No.: HY-P9921A Purity: 98.27%
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer.

For research use only. We do not sell to patients.

CAS No. : 1018448-65-1

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Based on 6 publication(s) in Google Scholar

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Trastuzumab emtansine (solution) Related Antibodies

Top Publications Citing Use of Products

    Trastuzumab emtansine (solution) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 0.001-10 nM; 5 days). In vitro evaluation of ADCs. Proliferation inhibitory activity of ADCs against NCI‐N87 (HER2+) cells. Tumor cells were treated with ADCs for 5 days and relative cell viability (%) was calculated.

    Trastuzumab emtansine (solution) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). The tumor volume change of bystander killing in co-inoculation xenograft model following a single intravenous ADC dose of 2 or 5 mg/kg.

    Trastuzumab emtansine (solution) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). Bystander killing in co-inoculation xenograft model following a single intravenous ADC dose of 2 or 5 mg/kg. Bioluminescence imaging data of luciferase activity.

    Trastuzumab emtansine (solution) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Apr;11(13):e2306309.  [Abstract]

    Trastuzumab emtansine (T-DM1; 5 mg/kg; intraperitoneal injection). HER2 expression on tumors consisting of either HER2‐positive or HER2‐negative cells, co‐inoculation (2: 5 ratio at the time of implantation) and the remaining and regrown tumors after treatment with each ADC.

    Trastuzumab emtansine (solution) purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Sep 8;16(9):1189.

    FACS analysis of ET-NK/T-DM1. ED-TM at 20 μg was added to NK cells to prepare ET-NK cells for 12 h at 37 ℃ and 5% CO2. The ET-NK cells were mixed with T-DM1 at 20 μg for 15 min at room temperature, resulting in the formation of ET-NK/T-DM1. ED-TM and T-DM1 were conjugated with rhodamine and FITC, respectively. Fluorescence on the ET-NK/T-DM1 was observed using CLSM. ED-TM: cell surface engineering fusion protein; T-DM1: trastuzumab emtansine; ET-NK: NK cell modified by ED-TM; ET-NK/T-DM1: ET-NK cell incorporated with T-DM1; FITC: fluorescein; CLSM: confocal laser scanning microscopy.

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    Description

    Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].

    In Vitro

    Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Trastuzumab emtansine (solution) Related Antibodies
    In Vivo

    Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    149114 (average)

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Trastuzumab emtansine (solution)]
    Shipping

    Shipping with dry ice.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 98.27%

    SDS (251 KB)

    COA (231 KB) SEC-HPLC (178 KB)

    Handling Instructions (2659 KB)
    References
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    Trastuzumab emtansine (solution) Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trastuzumab emtansine (solution)1018448-65-1Ado-Trastuzumab emtansine (solution)PRO132365 (solution)T-DM 1 (solution)EGFRAntibody-Drug Conjugates (ADCs)Epidermal growth factor receptorErbB-1HER1Antibody-Drug ConjugatesAntibody-Drug ConjugateADCDM1HER2Inhibitorinhibitorinhibit

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