1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. SMCC-DM1

SMCC-DM1 (Synonyms: DM1-SMCC)

Cat. No.: HY-101070 Purity: 99.02%
Handling Instructions

SMCC-DM1 (DM1-SMCC) est un conjugué de liaison de médicament composé d'un agent puissant de perturbation des microtubules DM1 et d'un SMCC de liaison pour fabriquer un conjugué anticorps-médicament (ADC).

SMCC-DM1 (DM1-SMCC) is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody drug conjugate (ADC).

For research use only. We do not sell to patients.

SMCC-DM1 Chemical Structure

SMCC-DM1 Chemical Structure

CAS No. : 1228105-51-8

Size Price Stock Quantity
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 516 In-stock
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25 mg USD 1068 In-stock
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50 mg USD 1860 In-stock
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100 mg USD 2640 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SMCC-DM1 (DM1-SMCC) is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody drug conjugate (ADC)[1].

IC50 & Target

Maytansinoids

 

In Vitro

SMCC-DM1 inhibits HCC1954 and MDA-MB-468 cells proliferation with IC50s of 17.2 and 49.9 nM, respectively[1].

Molecular Weight

1072.61

Formula

C₅₁H₆₆ClN₅O₁₆S

CAS No.

1228105-51-8

SMILES

O=C(O[[email protected]]([[email protected]@]1(C)[[email protected]]([[email protected]@H]([[email protected]@]2([H])OC(N[[email protected]]3(O)C2)=O)C)O1)CC(N(C)C4=CC(C/C(C)=C/C=C/[[email protected]]3OC)=CC(OC)=C4Cl)=O)[[email protected]@H](N(C(CCSC(C5=O)CC(N5CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)=O)=O)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (93.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9323 mL 4.6615 mL 9.3231 mL
5 mM 0.1865 mL 0.9323 mL 1.8646 mL
10 mM 0.0932 mL 0.4662 mL 0.9323 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.02%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

SMCC-DM1DM1-SMCCDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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SMCC-DM1
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