1. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  2. Antibody-Drug Conjugates (ADCs) EGFR
  3. Disitamab vedotin

Disitamab vedotin  (Synonyms: RC48)

Cat. No.: HY-P9985 Purity: ≥99.0%
COA Handling Instructions

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.

For research use only. We do not sell to patients.

Disitamab vedotin Chemical Structure

Disitamab vedotin Chemical Structure

CAS No. : 2136633-23-1

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1 mg USD 420 In-stock
5 mg USD 1250 In-stock
10 mg USD 1880 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Disitamab vedotin

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  • Purity & Documentation

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Description

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity[1].

IC50 & Target[1]

HER2

 

In Vitro

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Disitamab vedotin]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Disitamab vedotin
Cat. No.:
HY-P9985
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