Trastuzumab deruxtecan (solution) (Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution))

Name: Trastuzumab deruxtecan (solution)
Brand: MedChemExpress
SKU: HY-138298
Rating: 5.0 (5 reviews)

Cat. No.: HY-138298 Purity: 98.20%: Data Sheet
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Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer.

For research use only. We do not sell to patients.

CAS No. : 1826843-81-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 5 publication(s) in Google Scholar

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Trastuzumab deruxtecan In-stock

5 Publications Citing Use of MCE Trastuzumab deruxtecan (solution)

Cell Proliferation/Viability Assay

: Trastuzumab deruxtecan (solution) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Jun 11:725:150255. [Abstract]; Trastuzumab deruxtecan (1 μg/mL; 120 h). H2170 was treated with the indicated drugs and concentrations. Cell viability was measured by CellTiter-Glo assay or ONE-Glo Luciferase Assay.

: Trastuzumab deruxtecan (solution) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Jun 11:725:150255. [Abstract]; Trastuzumab deruxtecan (0-10 μg/mL; 72 h). JFCR-007 Luc-ZsG-positive cells were treated with T-DXd for 72 h in each co-culture conditions. Cell viability was measured by ONE-Glo Luciferase Assay.

: Trastuzumab deruxtecan (solution) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Jun 11:725:150255. [Abstract]; Trastuzumab deruxtecan (0-10 μg/mL; 120 h). The indicated cells were treated with serially diluted T-DXd for 120 h in a 2D culture condition.

: Trastuzumab deruxtecan (solution) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Jun 11:725:150255. [Abstract]; JFCR-007 was treated with or without T-DXd (10 μg/mL) for 120 h in spheroid condition.

: Trastuzumab deruxtecan (solution) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 Jun 11:725:150255. [Abstract]; Trastuzumab deruxtecan (1 μg/mL; 120 h). JFCR-007 was treated with the indicated drugs and concentrations. Cell viability was measured by CellTiter-Glo assay or ONE-Glo Luciferase Assay.

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Description

In Vitro

Trastuzumab deruxtecan (1 pM-10 nM; 5 days) (solution) inhibits the growth of HER2-positive KPL-4 cells, with an IC₅₀ of 109.7 pM^[2].
Trastuzumab deruxtecan (10 nM; 5 days) (solution) shows bystander killing effects in HER2-negative MDA-MB-468 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	KPL-4 and MDA-MB-468 cells
Concentration:	1, 10, 100, 1000, 10000 pM
Incubation Time:	5 days
Result:	Killed HER2-positive KPL-4 cells only.

In Vivo

Trastuzumab deruxtecan (3 mg/kg; a single i.v.) (solution) shows antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition^[2].
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) (solution) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice injected with NCI-N87 and MDA-MB-468-Luc cells^[2]
Dosage:	3 mg/kg
Administration:	A single i.v.
Result:	Almost all of the HER2-positive and HER-negative cells disappeared and there were little or no cancer cells remaining in the tumors.

Molecular Weight

153000 (average)

CAS No.

1826843-81-5

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Trastuzumab deruxtecan (solution)]

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light

Purity & Documentation

Purity: 99.40%

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Data Sheet (270 KB) SDS (251 KB)

COA (231 KB) Others (109 KB) SEC-HPLC (179 KB)

Handling Instructions (2659 KB)

References

[1]. Kumagai K, et al. Interstitial pneumonitis related to trastuzumab deruxtecan, a human epidermal growth factor receptor 2-targeting Ab-drug conjugate, in monkeys. Cancer Sci. 2020 Dec;111(12):4636-4645. [Content Brief]

[2]. Kotani D, et, al. Trastuzumab deruxtecan for the treatment of patients with HER2-positive gastric cancer. Ther Adv Med Oncol. 2021 Jan 7;13:1758835920986518. [Content Brief]

[3]. Ogitani Y, et, al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46. [Content Brief]

[4]. Iwata TN, et, al. [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model. PLoS One. 2019 Oct 1;14(10):e0222280. [Content Brief]

Trastuzumab deruxtecan (solution) Related Classifications

Cancer

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Trastuzumab deruxtecan (solution) (Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution))

Customer Review

Other Forms of Trastuzumab deruxtecan (solution):

Trastuzumab deruxtecan (solution) Related Antibodies

5 Publications Citing Use of MCE Trastuzumab deruxtecan (solution)

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