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Results for "

epidermal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EGFR (49) 5-HT Receptor (1) Akt (1) Antibody-Drug Conjugates (ADCs) (4) Apoptosis (4) Biochemical Assay Reagents (1) BMX Kinase (1) Bradykinin Receptor (1) Btk (1) Calcium Channel (2) Cannabinoid Receptor (2) Casein Kinase (1) CDK (1) COX (1) Drug-Linker Conjugates for ADC (1) Elastase (1) Endogenous Metabolite (4) ERK (4) GPR35 (1) HIF/HIF Prolyl-Hydroxylase (1) IGF-1R (1) Interleukin Related (2) Kallikrein (1) MEK (1) Melanocortin Receptor (1) Notch (1) PD-1/PD-L1 (1) Phosphatase (2) PI3K (1) Piezo Channel (1) PKA (1) Potassium Channel (1) PROTACs (1) Reactive Oxygen Species (3) STAT (1) STING (1) Thymidylate Synthase (1) Topoisomerase (3) Tyrosinase (1) VEGFR (2)
By Research Areas:	Cancer (58) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (3)
Click Chemistry:	Alkynes (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: EGFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1960A

Epidermal growth factor (EGF) (phosphate) 3 Publications Verification	EGFR	Metabolic Disease Cancer
Epidermal growth factor (EGF) is a potent epidermal growth factor, stimulates the proliferation of epidermal cells and is used in wound healing applications .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Endogenous Metabolite	Inflammation/Immunology
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-P1960

Epidermal growth factor (EGF)	Apoptosis Reactive Oxygen Species	Cancer
Epidermal growth factor (EGF) is the key regulatory factor in promoting cell survival. Epidermal growth factor (EGF) signaling pathways are related with apoptosis. Loss of Epidermal growth factor (EGF) leads to embryonic or perinatal lethality with abnormalities in multiple organs. Epidermal growth factor (EGF) can stimulate reactive oxygen species (ROS) production for a short period of time in cells. Epidermal growth factor (EGF) can be used to research development and cancer .

HY-P1085

Epidermal Growth Factor Receptor Peptide (985-996)	EGFR	Cancer
Epidermal Growth Factor Receptor Peptide (985-996) is an amino acid peptide fragment derived from positions 985-996 in epidermal growth factor receptor (EGFR) .

HY-132259

Depatuxizumab mafodotin ABT-414	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Depatuxizumab mafodotin is an antibody-drug conjugate (ADC) that specifically targets the epidermal growth factor receptor (EGFR). Depatuxizumab mafodotin can be used for cancer research .

HY-N1658

2,3-Dihydroisoginkgetin	Tyrosinase	Others
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

HY-138298A

Trastuzumab deruxtecan 1 Publications Verification DS-8201; DS-8201a	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (DS-8201a) is an anti-*human epidermal* growth factor receptor 2 (HER2) antibody-drug conjugate (ADC)**. Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .

HY-100923

H-9 Dihydrochloride	PKA 5-HT Receptor EGFR	Neurological Disease
H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines .

HY-138298

Trastuzumab deruxtecan (solution) 1 Publications Verification DS-8201 (solution); DS-8201a (solution)	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-*human epidermal* growth factor receptor 2 (HER2) antibody-drug conjugate (ADC)**. Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .

HY-117081

C30(ω-hydroxy) Ceramide (d18:1/30:0)	Others	Others
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-111378A

Casein Kinase II Inhibitor IV hydrochloride

Casein Kinase Others

Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation.

Casein Kinase II Inhibitor IV hydrochloride	Casein Kinase	Others
Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation.

HY-144680

BLU-945 ZL-2313	EGFR	Cancer
BLU-945 is a potent, highly selective, reversible and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC) .

HY-150782

UNC-CA359	EGFR	Cancer
UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC₅₀ value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research . UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160613

EGFR/HER2-IN-11	EGFR	Cancer
EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC₅₀s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI₅₀ of 601 nM .

HY-12806

AG1557

EGFR Cancer

AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC₅₀ value of 8.194 .
HY-115716

EGFR-IN-17

EGFR Cancer

EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor ( IC₅₀ 0.0002 μM) to overcome C797S-mediated resistance.

AG1557	EGFR	Cancer
AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC₅₀ value of 8.194 .

EGFR-IN-17	EGFR	Cancer
EGFR-IN-17 is a potent and selective inhibitor of the epidermal growth factor receptor ( IC₅₀ 0.0002 μM) to overcome C797S-mediated resistance.

HY-125407

Palmitoyl serinol N-Palmitoyl serinol	Cannabinoid Receptor	Inflammation/Immunology
Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin .

HY-P9905

Cetuximab Maximum Cited Publications 25 Publications Verification C225	EGFR	Cancer
Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a K_d of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .

HY-U00002

ZD-4190	VEGFR EGFR	Cancer
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.

HY-131864

SJF-1528	EGFR PROTACs	Cancer
SJF-1528 is a potent EGFR PROTAC degrader with DC₅₀ values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 also degrades HER2 .

HY-148949

Kallikrein 5-IN-2	Kallikrein	Others
Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC₅₀=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching .

HY-162099

VEGFR-IN-4	EGFR	Cancer
VEGFR-IN-4 (Compound 6e) is an epidermal growth factor receptor (EGFR) inhibitor. VEGFR-IN-4 has potent antiproliferative activity with an IC₅₀ value of 24.6nM against HCC827 cells .

HY-18963

Lavendustin A RG-14355
Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC₅₀ of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis .

HY-N0128

Sclareol 1 Publications Verification	Apoptosis	Cancer
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-155189

IIIM-8	Melanocortin Receptor	Others
IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research .

HY-100214

EAI001
EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC₅₀ value of 24 nM for EGFR ^L858R/T790M. EAI001 can be used for research of cancer .

HY-P4669

KLK7/ELA2-IN-1	Elastase	Cancer
KLK7/ELA2-IN-1 is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC₅₀s of 6 nM and 55 nM, respectively (WO2009024527A1, Example 4) .

HY-N8473

Pericosine A (+)-Pericosine A	Topoisomerase	Cancer
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-19909

NRC-2694	EGFR	Cancer
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. NRC-2694 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-114456

Ganglioside GM3	Others	Metabolic Disease
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-125407S

Palmitoyl serinol-d5 N-Palmitoyl serinol-d₅	Cannabinoid Receptor	Inflammation/Immunology
Palmitoyl serinol-d₅ is the deuterium labeled Palmitoyl serinol[1]. Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin[2][3].

HY-P9985

Disitamab vedotin 1 Publications Verification RC48	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity .

HY-P1799A

[pTyr5] EGFR (988-993) (TFA)	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Others	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

HY-E70229

Cyclooxygenase 1, sheep COX-1	Endogenous Metabolite	Metabolic Disease
Cyclooxygenase 1, sheep (COX-1) is a 71 kDa membrane bound protein predominantly present in endoplasmic reticulum. Cyclooxygenase 1 has three domains, the epidermal growth factor (EGF) like domain, enzymatic and membrane binding domain. Cyclooxygenase 1 mediates prostaglandin synthesis and is modulated by anti-inflammatory nonsteroidal drugs .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-139300

Epitinib HMPL-813	EGFR	Cancer
Epitinib is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib can be used for the research of cancer . Epitinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P1855

HER2/neu (654-662) GP2	EGFR	Cancer
HER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers .

HY-N2459

Peonidin chloride YGM-6 chloride	COX	Cancer
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-101958

Tyrphostin 25 AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875	EGFR GPR35	Inflammation/Immunology Cancer
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC₅₀ of 0.94 µM and an EC₅₀ of 5.3 µM .

HY-18723

Yoda 1 Maximum Cited Publications 25 Publications Verification	Piezo Channel Akt ERK Potassium Channel	Cardiovascular Disease
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca ²⁺ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .

HY-139300A

Epitinib succinate HMPL-813 succinate	EGFR	Cancer
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144048

EGFR-IN-31	EGFR	Cancer
EGFR-IN-31 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-31 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185298A1, compound 2) .

HY-144049

EGFR-IN-32	EGFR	Cancer
EGFR-IN-32 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-32 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185297A1, compound 2) .

HY-145867

EGFR-IN-45	Topoisomerase EGFR CDK Apoptosis	Cancer
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC₅₀s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis .

HY-150781

EGFR-IN-71	EGFR	Cancer
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC₅₀ values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma . EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149517

EGFR/BRAFV600E-IN-2	EGFR	Cancer
E07 aptamer is an aptamer that targets human epidermal growth factor receptor (hEGFR). E07 aptamer can compete with EGF for binding, binds to a novel epitope on EGFR. E07 aptamer binds to cells expressing EGFR, blocks receptor autophosphorylation, and prevents proliferation of tumor cells in three-dimensional matrices. E07 aptamer can be used for tomor disease research .

Cat. No.	Product Name

HY-L075

Anti-Lung Cancer Compound Library

1835 compounds

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers.

As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy.

MCE offers a unique collection of 1835 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

HY-L074

Anti-Breast Cancer Compound Library

1953 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 1953 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Target	Research Area

HY-P1960A

Epidermal growth factor (EGF) (phosphate) 3 Publications Verification	EGFR	Metabolic Disease Cancer
Epidermal growth factor (EGF) is a potent epidermal growth factor, stimulates the proliferation of epidermal cells and is used in wound healing applications .

HY-P1960

Epidermal growth factor (EGF)	Apoptosis Reactive Oxygen Species	Cancer
Epidermal growth factor (EGF) is the key regulatory factor in promoting cell survival. Epidermal growth factor (EGF) signaling pathways are related with apoptosis. Loss of Epidermal growth factor (EGF) leads to embryonic or perinatal lethality with abnormalities in multiple organs. Epidermal growth factor (EGF) can stimulate reactive oxygen species (ROS) production for a short period of time in cells. Epidermal growth factor (EGF) can be used to research development and cancer .

HY-P1085

Epidermal Growth Factor Receptor Peptide (985-996)	EGFR	Cancer
Epidermal Growth Factor Receptor Peptide (985-996) is an amino acid peptide fragment derived from positions 985-996 in epidermal growth factor receptor (EGFR) .

HY-P4286

H-Gly-Leu-Phe-OH	Peptides	Cancer
H-Gly-Leu-Phe-OH (GLF), an immunostimulatory tripeptide derived from α-lactalbumin, inhibits anticancer agent Etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer .

HY-P4669

KLK7/ELA2-IN-1	Elastase	Cancer
KLK7/ELA2-IN-1 is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC₅₀s of 6 nM and 55 nM, respectively (WO2009024527A1, Example 4) .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1799A

[pTyr5] EGFR (988-993) (TFA)	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1855

HER2/neu (654-662) GP2	EGFR	Cancer
HER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers .

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research .

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-P1845A

PACAP-38 (31-38), human, mouse, rat TFA	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat TFA is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat TFA elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat TFA can be used for neurotrophic and neuroprotective research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Interleukin Related Endogenous Metabolite
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-N0128

Sclareol 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Plants Artemisia mexicana Willd. Erigeron breviscapus (Vant.) Hand.-Mazz. Disease Research Fields Cancer	Apoptosis
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N1658

2,3-Dihydroisoginkgetin	Podocarpus macrophyllus (Thunb.) Sweet Flavonoids Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Podocarpaceae Biflavones Disease Research Fields	Tyrosinase
2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC₅₀ of 86.16 μM .

HY-117081

C30(ω-hydroxy) Ceramide (d18:1/30:0)	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Others
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

HY-N8473

Pericosine A (+)-Pericosine A	Structural Classification Natural Products Microorganisms Source classification	Topoisomerase
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-N2459

Peonidin chloride YGM-6 chloride	Classification of Application Fields Source classification Plants Food Research Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Phenols Polyphenols Pigments Paeoniaceae Disease Research Fields Cancer	COX
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-N10330

7-Hydroxyneolamellarin A	Structural Classification Animals Source classification Phenols	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

Species:	Human (20) Rhesus Macaque (3) Mouse (15) Rat (4) Cynomolgus (3) Canine (3) Pig (1)
Tag:	His (28) Tag Free (9) Myc (1) GST (2) Fc (12)
Source:	HEK293 (24) CHO (1) P. pastoris (5) Sf9 insect cells (7) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P70590

	EGF Protein, Mouse (His) 2 Publications Verification Pro-epidermal growth factor; epidermal growth factor; EGF	Mouse	E. coli
	EGF Protein, a growth factor, is essential for cell growth, proliferation, and differentiation. It binds to the EGF receptor, activating signaling pathways that regulate cell survival and tissue repair. EGF Protein has therapeutic potential in promoting wound healing, tissue regeneration, and cancer treatment. Its role in cellular processes makes it a subject of interest in biomedical research. EGF Protein, Mouse (His) is the recombinant mouse-derived EGF protein, expressed by E. coli , with C-6*His labeled tag. The total length of EGF Protein, Mouse (His) is 53 a.a., with molecular weight of 9-14 kDa.

HY-P70590AF

	Animal-Free EGF Protein, Mouse (His) 1 Publications Verification Pro-epidermal growth factor; epidermal growth factor; EGF	Mouse	E. coli
	EGF Protein, a growth factor, is essential for cell growth, proliferation, and differentiation. It binds to the EGF receptor, activating signaling pathways that regulate cell survival and tissue repair. EGF Protein has therapeutic potential in promoting wound healing, tissue regeneration, and cancer treatment. Its role in cellular processes makes it a subject of interest in biomedical research. Animal-Free EGF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeEGF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free EGF Protein, Mouse (His) is 53 a.a., with molecular weight of ~6.98 kDa.

HY-P700485

	EPS15 Protein, Human (His) Eps15 epidermal; growth factor receptor pathway substrate 15; 2410112D09Rik; epidermal growth factor receptor substrate 15; epidermal growth factor pathway substrate 15; protein AF-1p	Human	E. coli
	EPS15 is a multifunctional protein that regulates cell growth, controls mitotic signaling, and contributes to receptor tyrosine kinase (RTK) internalization, particularly affecting EGFR. As a clathrin adapter, EPS15 is critical for the assembly and maturation of clathrin-coated pits (CCP), affecting the endocytosis of molecules such as ITGB1 and transferrin receptor (TFR). EPS15 Protein, Human (His) is the recombinant human-derived EPS15 protein, expressed by E. coli , with N-6*His labeled tag. The total length of EPS15 Protein, Human (His) is 142 a.a., with molecular weight of 20.9 kDa.

HY-P70073

	Betacellulin/BTC Protein, Mouse (His) rMuBetacellulin/Btc, His; Btc; Betacellulin; Betacellulin; epidermal growth factor family member; Betacellulin; epidermal growth factor family member; isoform CRA_a; mCG_12529	Mouse	E. coli
	Betacellulin (BTC) is missing crucial conserved residue(s) for feature annotation propagation. Betacellulin/BTC Protein, Mouse (His) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by E. coli , with N-6*His labeled tag. The total length of Betacellulin/BTC Protein, Mouse (His) is 87 a.a., with molecular weight of 13-16 kDa.

HY-P71734

	FLG Protein, Human (P.pastoris, His) ATOD2; epidermal filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin	Human	P. pastoris
	FLG Protein, essential in the mammalian epidermis, plays a key role in terminal differentiation. It aggregates keratin intermediate filaments and promotes disulfide bond formation, emphasizing its crucial contribution to the structural organization and integrity of the epidermis in the concluding stages of cellular differentiation. FLG Protein, Human (P.pastoris, His) is the recombinant human-derived FLG protein, expressed by P. pastoris , with N-His labeled tag. The total length of FLG Protein, Human (P.pastoris, His) is 224 a.a., with molecular weight of ~26.8 kDa.

HY-P72986

	EGFR Protein, Canine (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Canine	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein participate in the NF-kappa-B signaling pathway. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein, Canine (sf9, His) is the recombinant canine-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of EGFR Protein, Canine (sf9, His) is 618 a.a., with molecular weight of ~87.2 kDa.

HY-P72988

	EGFR Protein, Mouse (HEK293, Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Mouse (HEK293, Fc) is 623 a.a., with molecular weight of ~142.57 kDa.

HY-P72989

	EGFR Protein, Mouse (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Mouse (HEK293, His) is 647 a.a., with molecular weight of ~100 kDa.

HY-P72990

	EGFR Protein, Rat (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rat	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Rat (HEK293, His) is the recombinant rat-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Rat (HEK293, His) is 622 a.a., with molecular weight of 93-110 kDa.

HY-P75259

	EGFR Protein, Cynomolgus (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Cynomolgus	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of EGFR Protein, Cynomolgus (sf9, His) is 621 a.a., with molecular weight of ~70.1 kDa.

HY-P75260

	EGFR Protein, Cynomolgus (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Cynomolgus	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Cynomolgus (HEK293, His) is 621 a.a., with molecular weight of ~93.8 kDa.

HY-P702751

EGFR Protein, Human (sf9, GST)

epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1
Human Sf9 insect cells

HY-P72987

	EGFR Protein, Human (sf9, His-GST) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (sf9, His-GST) is the recombinant human-derived EGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EGFR Protein, Human (sf9, His-GST) is 543 a.a., with molecular weight of ~89.1 kDa.

HY-P75256

	EGFR Protein, Rhesus Macaque (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of EGFR Protein, Rhesus Macaque (sf9, His) is 645 a.a., with molecular weight of ~70.1 kDa.

HY-P75258

	EGFR Protein, Rhesus Macaque (HEK293, Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Rhesus Macaque (HEK293, Fc) is 645 a.a., with molecular weight of ~95.4 kDa.

HY-P74177

	EGFR Protein, Human (621a.a, HEK293, Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	EGFR Protein, a receptor tyrosine kinase, binds various ligands like EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, initiating signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation, and recruitment of adapter proteins like GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC, and STATs. EGFR can also trigger NF-kappa-B signaling, phosphorylate proteins like RGS16, and interact with MUC1, influencing G protein-coupled receptor signaling. Moreover, it enhances cell migration through interactions with CCDC88A, promoting EGFR signaling and triggering cell migration. Additionally, EGFR impacts learning, memory, and pain signaling. EGFR Protein, Human (621a.a, HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of EGFR Protein, Human (621a.a, HEK293, Fc) is 621 a.a., with molecular weight of 110-160 kDa.

HY-P73517

	EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is 621 a.a., with molecular weight of ~99.5 kDa.

HY-P75257

	EGFR Protein, Rhesus Macaque (645a.a, HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (645a.a, HEK293, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of EGFR Protein, Rhesus Macaque (645a.a, HEK293, His) is 621 a.a., with molecular weight of ~93.85 kDa.

HY-P79398

	FABP5/E-FABP Protein, Mouse (His) Fatty acid-binding protein 5; Fabp5; epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein, epidermal; Keratinocyte lipid-binding protein; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; Fabpe; Klbp; Mal1	Mouse	E. coli
	FABP5, also known as E-FABP, acts as an intracellular carrier of long-chain fatty acids and related lipids and regulates ligand metabolism. In addition to cytoplasmic transport, it selectively transports fatty acids to the nucleus, activates nuclear receptors, and delivers retinoic acid to promote proliferation. FABP5/E-FABP Protein, Mouse (His) is the recombinant mouse-derived FABP5/E-FABP protein, expressed by E. coli , with N-6*His labeled tag. The total length of FABP5/E-FABP Protein, Mouse (His) is 135 a.a., with molecular weight of ~16 kDa.

HY-P700409

	EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	EGFR Protein, a receptor tyrosine kinase, binds various ligands like EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, initiating signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation, and recruitment of adapter proteins like GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC, and STATs. EGFR can also trigger NF-kappa-B signaling, phosphorylate proteins like RGS16, and interact with MUC1, influencing G protein-coupled receptor signaling. Moreover, it enhances cell migration through interactions with CCDC88A, promoting EGFR signaling and triggering cell migration. Additionally, EGFR impacts learning, memory, and pain signaling. EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) is the recombinant human-derived EGFR protein, expressed by HEK293, with C-Myc, N-10*His labeled tag. The total length of EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) is 621 a.a., with molecular weight of 73.6 kDa.

HY-P75730

	EGFL7/VE-Statin Protein, Human (sf9, His) epidermal growth factor-like protein 7; NOTCH4-like protein; VE-statin; MEGF7	Human	Sf9 insect cells
	EGFL7/VE-statin is an important coordinator of vascular dynamics, affecting angiogenesis in vivo and inhibiting PDGF-BB-induced smooth muscle cell migration, thereby affecting vascular remodeling. It plays a key role in promoting endothelial cell adhesion and contributes to angiogenesis, emphasizing its regulatory influence on vascular development. EGFL7/VE-Statin Protein, Human (sf9, His) is the recombinant human-derived EGFL7/VE-Statin protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of EGFL7/VE-Statin Protein, Human (sf9, His) is 250 a.a., with molecular weight of ~31 kDa.

HY-P75731

	EGFL7/VE-Statin Protein, Mouse (sf9, His) epidermal growth factor-like protein 7; NOTCH4-like protein; VE-statin; MEGF8	Mouse	Sf9 insect cells
	EGFL7/VE-Statin Protein regulates in vivo vascular tubulogenesis by inhibiting PDGF-BB-induced smooth muscle cell migration, promoting endothelial cell adhesion, and facilitating angiogenesis. It enhances endothelial cell motility through RGD-dependent interaction with ITGAV/ITGB3. EGFL7/VE-Statin Protein, Mouse (sf9, His) is the recombinant mouse-derived EGFL7/VE-Statin protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of EGFL7/VE-Statin Protein, Mouse (sf9, His) is 254 a.a., with molecular weight of ~34 kDa.

HY-P76315

	EGFL6 Protein, Mouse (HEK293, Fc) epidermal growth factor-like protein 6; EGF-like protein 6; Protein W80; Maeg	Mouse	HEK293
	The EGFL6 protein is a key player in hair follicle morphogenesis and may influence cell dynamics through binding to integrin α-8/β-1. This interaction is shown to play a key role in the complex process that controls hair follicle formation. EGFL6 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFL6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFL6 Protein, Mouse (HEK293, Fc) is 264 a.a., with molecular weight of ~56.8 KDa.

HY-P76316

	EGFL6 Protein, Mouse (HEK293, His) epidermal growth factor-like protein 6; EGF-like protein 6; Protein W80; Maeg	Mouse	HEK293
	The EGFL6 protein is a key player in hair follicle morphogenesis and may influence cell dynamics through binding to integrin α-8/β-1. This interaction is shown to play a key role in the complex process that controls hair follicle formation. EGFL6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EGFL6 protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFL6 Protein, Mouse (HEK293, His) is 264 a.a., with molecular weight of ~31.5 KDa.

HY-P70608

	EGFR Protein, Human (HEK293, Fc) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Human (HEK293, Fc) is 354 a.a., with molecular weight of 90-120 kDa.

HY-P70613

	EGFR Protein, Human (621a.a, HEK293, His) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EGFR Protein, Human (621a.a, HEK293, His) is 621 a.a., with molecular weight of 90-120 kDa.

HY-P71112

	TDGF1 Protein, Human (HEK293, Fc) Teratocarcinoma-derived growth factor 1; Cripto-1 growth factor; CRGF; epidermal growth factor-like cripto protein CR1; TDGF1; CRIPTO	Human	HEK293
	The TDGF1 protein is a GPI-anchored cell membrane protein involved in Nodal signaling. TDGF1 Protein, Human (HEK293, Fc) is the recombinant human-derived TDGF1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TDGF1 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of ~51.0 kDa.

HY-P70189

	EGFR vIII Protein, Human (HEK293, His) rHuepidermal Growth Factor Receptor/EGFR vIII, His; epidermal growth factor receptor; EGFR; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR	Human	HEK293
	The EGFRvIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor. It acts on the cell surface, binds to epidermal growth factor, triggers receptor dimerization and tyrosine autophosphorylation, and promotes cell proliferation. EGFR vIII Protein, Human (HEK293, His) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EGFR vIII Protein, Human (HEK293, His) is 354 a.a., with molecular weight of 61-75 kDa.

HY-P700693

CLEC14A Protein, Human (HEK293, His)

epidermal growth factor receptor 5; EGFR-5; EGFR 5; EGFR5; C14orf27; UNQ236; PRO269; CEG1
Human HEK293
HY-P702629

DLK2 Protein, Mouse (P.pastoris, His)

Protein delta homolog 2; epidermal growth factor-like protein 9 (EGF-like protein 9); Endothelial cell-specific protein S-1; Egfl9
Mouse P. pastoris

HY-P7067

	EGF Protein, Mouse rMuEGF; Pro-epidermal growth factor; Urogastrone	Mouse	E. coli
	EGF Protein, Mouse is a growth factor that stimulates the proliferation of the epidermis and several epithelial tissues.

HY-P7092

	EGF Protein, Rat 2 Publications Verification rRtEGF; Pro-epidermal growth factor; Urogastrone	Rat	E. coli
	EGF Protein, Rat is a potent epidermal growth factor, promotes epithelial proliferation and migration, and increases epithelial wound closure and shortens healing time.

HY-P7109

	EGF Protein, Human Maximum Cited Publications 28 Publications Verification rHuEGF; Pro-epidermal growth factor; Urogastrone	Human	E. coli
	EGF Protein, Human is a potent epidermal growth factor, stimulates the proliferation of epidermal cells and is used in wound healing applications.

HY-P7092A

	EGF Protein, Rat (CHO) rRtEGF; Pro-epidermal growth factor; Urogastrone	Rat	CHO
	EGF Protein, Rat (CHO) is a potent epidermal growth factor, promotes epithelial proliferation and migration, and increases epithelial wound closure and shortens healing time.

HY-P7109G

	GMP EGF Protein, Human 1 Publications Verification Pro-epidermal growth factor; EGF; Urogastrone	Human	E. coli
	EGF proteins act as potent stimulators of growth in a variety of epidermal and epithelial tissues in both in vivo and in vitro settings, while promoting the proliferation of specific fibroblasts in cell culture. This multifaceted protein also acts as a magnesium stimulating hormone, driving magnesium reabsorption in the renal distal tubule through engagement of EGFR and activation of the magnesium channel TRPM6. GMP EGF Protein, Human is the recombinant human-derived EGF protein, expressed by E. coli , with tag free. The total length of GMP EGF Protein, Human is 53 a.a., with molecular weight of ~9.6 kDa.

HY-P72981

	EGF Protein, Canine (His) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Canine	E. coli
	The EGF protein plays a key role in promoting the growth of a variety of epidermal and epithelial tissues in vivo and in vitro and in stimulating the proliferation of certain fibroblasts in cell culture. In addition, it also has the effect of magnesium-stimulating hormone, causing magnesium reabsorption in the renal distal convoluted tubule through the participation of EGFR and the activation of magnesium channel TRPM6. EGF Protein, Canine (His) is the recombinant canine-derived EGF protein, expressed by E. coli , with N-His labeled tag. The total length of EGF Protein, Canine (His) is 52 a.a., with molecular weight of 16-22 kDa.

HY-P7092Y

	EGF Protein, Rat (Tag Free, Solution) rRtEGF; Pro-epidermal growth factor; Urogastrone	Rat	E. coli
	EGF Protein, Rat is a potent epidermal growth factor, promotes epithelial proliferation and migration, and increases epithelial wound closure and shortens healing time.

HY-P72980

	EGF Protein, Canine (P.pastoris) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Canine	P. pastoris
	The EGF protein plays a key role in promoting the growth of a variety of epidermal and epithelial tissues in vivo and in vitro and in stimulating the proliferation of certain fibroblasts in cell culture. In addition, it also has the effect of magnesium-stimulating hormone, causing magnesium reabsorption in the renal distal convoluted tubule through the participation of EGFR and the activation of magnesium channel TRPM6. EGF Protein, Canine (P.pastoris) is the recombinant canine-derived EGF protein, expressed by P. pastoris , with tag free. The total length of EGF Protein, Canine (P.pastoris) is 52 a.a., with molecular weight of ~6.2 kDa.

HY-P72983

	EGF Protein, Mouse (HEK293) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Mouse	HEK293
	EGF Protein, a growth factor, is essential for cell growth, proliferation, and differentiation. It binds to the EGF receptor, activating signaling pathways that regulate cell survival and tissue repair. EGF Protein has therapeutic potential in promoting wound healing, tissue regeneration, and cancer treatment. Its role in cellular processes makes it a subject of interest in biomedical research. EGF Protein, Mouse (HEK293) is the recombinant mouse-derived EGF protein, expressed by HEK293 , with tag free. The total length of EGF Protein, Mouse (HEK293) is 53 a.a., with molecular weight of ~7 kDa.

HY-P72984

	EGF Protein, Mouse (P.pastoris) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Mouse	P. pastoris
	EGF Protein, a growth factor, is essential for cell growth, proliferation, and differentiation. It binds to the EGF receptor, activating signaling pathways that regulate cell survival and tissue repair. EGF Protein has therapeutic potential in promoting wound healing, tissue regeneration, and cancer treatment. Its role in cellular processes makes it a subject of interest in biomedical research. EGF Protein, Mouse (P.pastoris) is the recombinant mouse-derived EGF protein, expressed by P. pastoris , with tag free. The total length of EGF Protein, Mouse (P.pastoris) is 53 a.a., with molecular weight of ~6 kDa.

HY-P72985

	EGF Protein, Mouse (HEK293, Fc) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Mouse	HEK293
	EGF Protein, a growth factor, is essential for cell growth, proliferation, and differentiation. It binds to the EGF receptor, activating signaling pathways that regulate cell survival and tissue repair. EGF Protein has therapeutic potential in promoting wound healing, tissue regeneration, and cancer treatment. Its role in cellular processes makes it a subject of interest in biomedical research. EGF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of EGF Protein, Mouse (HEK293, Fc) is 53 a.a., with molecular weight of ~44 & 38 kDa, respectively.

HY-P700236AF

	Animal-Free EGF Protein, Pig (His) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Pig	E. coli
	The EGF protein acts as a potent stimulator of growth in a variety of epidermal and epithelial tissues in both in vivo and in vitro settings and exhibits growth-promoting effects on certain fibroblasts in cell culture. Animal-Free EGF Protein, Pig (His) is the recombinant pig-derived animal-FreeEGF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free EGF Protein, Pig (His) is 53 a.a., with molecular weight of ~7.1 kDa.

HY-P77303

	Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) Btc; Betacellulin; Betacellulin epidermal growth factor family member	Cynomolgus	HEK293
	Betacellulin/BTC Protein, a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. In addition, BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is 111 a.a., with molecular weight of 45-55 kDa.

HY-P72982A

	EGF Protein, Human (HEK293, N-hFc) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Human	HEK293
	The Progranulin/PGRN protein is involved in a variety of cellular processes, including cell growth, inflammation, and neurodegeneration. It acts as a regulator of tissue repair and has been implicated in the pathogenesis of several diseases, including Alzheimer's disease and frontotemporal dementia. Progranulin/PGRN interacts with various receptors and signaling pathways to exert its effects on cellular function and disease progression. EGF Protein, Human (HEK293, N-hFc) is the recombinant human-derived EGF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of EGF Protein, Human (HEK293, N-hFc) is 53 a.a., with molecular weight of ~33-38 kDa.

HY-P72982

	EGF Protein, Human (Solution, HEK293, N-hFc) Pro-epidermal growth factor; Urogastrone; EGF; HOMG4	Human	HEK293
	The Progranulin/PGRN protein is involved in a variety of cellular processes, including cell growth, inflammation, and neurodegeneration. It acts as a regulator of tissue repair and has been implicated in the pathogenesis of several diseases, including Alzheimer's disease and frontotemporal dementia. Progranulin/PGRN interacts with various receptors and signaling pathways to exert its effects on cellular function and disease progression. EGF Protein, Human (Solution, HEK293, N-hFc) is the recombinant human-derived EGF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of EGF Protein, Human (Solution, HEK293, N-hFc) is 53 a.a., with molecular weight of ~37 kDa.

HY-P75478

	Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) Btc; Betacellulin; Betacellulin epidermal growth factor family member	Mouse	HEK293
	Betacellulin/BTC Protein, a growth factor with affinity for EGFR, ERBB4, and other EGF receptor family members, exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Its molecular activity involves interactions with EGFR and ERBB4, contributing to cellular signaling and regulation. Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is 87 a.a., with molecular weight of 50-55 kDa.

HY-P76490

	MEGF10 Protein, Human (HEK293, Fc) Multiple epidermal growth factor-like domains protein 10; KIAA1780	Human	HEK293
	The MEGF10 protein is a membrane receptor that plays a key role in phagocytosis by macrophages and astrocytes, specifically the clearance of apoptotic cells through C1q binding to phosphatidylserine. MEGF10 cooperates with ABCA1 to contribute to the formation of large vacuoles and may facilitate amyloid-beta peptide uptake. MEGF10 Protein, Human (HEK293, Fc) is the recombinant human-derived MEGF10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of MEGF10 Protein, Human (HEK293, Fc) is 857 a.a., with molecular weight of ~90.2 KDa.

HY-P76491

	MEGF10 Protein, Human (HEK293, His) Multiple epidermal growth factor-like domains protein 10; KIAA1780	Human	HEK293
	The MEGF10 protein is a membrane receptor that plays a key role in phagocytosis by macrophages and astrocytes, specifically the clearance of apoptotic cells through C1q binding to phosphatidylserine. MEGF10 cooperates with ABCA1 to contribute to the formation of large vacuoles and may facilitate amyloid-beta peptide uptake. MEGF10 Protein, Human (HEK293, His) is the recombinant human-derived MEGF10 protein, expressed by HEK293 , with C-His labeled tag. The total length of MEGF10 Protein, Human (HEK293, His) is 832 a.a., with molecular weight of 95-120 KDa.

HY-P700489

	TDGF1P3 Protein, Human (P. pastoris, His) Cripto-3 growth factor (epidermal growth factor-like cripto protein CR3); Teratocarcinoma-derived growth factor 1 pseudogene 3; CRIPTO3; TDGF2; TDGF3	Human	P. pastoris
	The TDGF1P3 protein is a protein that may be involved in the determination of ectodermal cells, which in turn contribute to mesoderm development. Its effects are exerted through activation of node-dependent signaling pathways, suggesting its role in complex processes regulating cell fate and tissue differentiation. TDGF1P3 Protein, Human (P. pastoris, His) is the recombinant human-derived TDGF1P3 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of TDGF1P3 Protein, Human (P. pastoris, His) is 158 a.a., with molecular weight of 18.6 kDa.

Cat. No.	Product Name	Chemical Structure

HY-125407S

Palmitoyl serinol-d5
Palmitoyl serinol-d₅ is the deuterium labeled Palmitoyl serinol[1]. Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin[2][3].

HY-113509S

Lipoxin A4-d5

Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

Cat. No.	Product Name	Application	Reactivity

HY-P81420

GRB7 Antibody (YA1165)

B47; epidermal growth factor receptor GRB 7; GRB7 adapter protein; GRB7
IHC-P Human

HY-P80648

EGFR Antibody (YA775) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IP	Human, Monkey
EGFR Antibody (YA775) is a non-conjugated and Mouse origined monoclonal antibody about 134 kDa, targeting to EGFR (6H11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Monkey.

HY-P80808

Phospho-EGFR (Tyr1068) Antibody EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF	Human
Phospho-EGFR (Tyr1068) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1068). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80809

Phospho-EGFR (Tyr1092) Antibody EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-P	Human, Mouse, Rat
Phospho-EGFR (Tyr1092) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1092). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80810

Phospho-EGFR (Tyr1173) Antibody EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
Phospho-EGFR (Tyr1173) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1173). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P81694

Flotillin 2 Antibody (YA1439)

epidermal surface antigen; ESA; flotillin-2; Membrane component chromosome 17 surface marker 1; ESA1; M17S1
WB, IP Human, Mouse, Rat

HY-P82926

Cytokeratin 2e Antibody (YA2671) KRT2; KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84; Keratin; type II cytoskeletal 2 epidermal; Keratin; type II cytoskeletal 2 oral; Keratin; type II cytoskeletal 3; Keratin; type II cytoskeletal 5; Keratin; type II cytoskeletal 6A; Keratin; type II cytoskeletal 6B; Keratin; type II cytoskeletal 6C; Keratin; type II cytoskeletal 71; Keratin; type II cytoskeletal 72; Keratin; type II cytoskeletal 73; Keratin; type II cytoskeletal 74	WB, IHC-P	Human

Cat. No.	Product Name		Classification