Retifanlimab
Based on 1 Customer Validation
Retifanlimab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb). Retifanlimab can be used for the research of gastroesophageal adenocarcinoma (GEA).
For research use only. We do not sell to patients.
- Purity : 96.84%
- CAS No.: 2079108-44-2
- Molecular Weight:145.35 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
PDCD1/PD-1/CD279
In Vitro
Retifanlimab blocks the binding of PD-L1 to PD-1, inhibits the activation of SHP-2, and promotes the secretion of cytokine IFN-γ. Retifanlimab restores the activity of T cells and enhances the immune system's attack on tumor cells[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human PD-1 Protein (ECD, His Tag) can bind Retifanlimab. The EC50 for this effect is 3.71 ng/mL. -
Flow cytometric analysis of 1X10^6 10 ng/mL PMA and 1 μg/mL Ionomycin co-stimulated Jurkat cells(24h) labeling Retifanlimab (HY-P99941, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2079108-44-2
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Appearance Liquid
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Molecular Weight 145.35 kDa
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Color Colorless to light yellow
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SMILES
[Retifanlimab]
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Synonyms
INCMGA-00012; MGA-012
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Retifanlimab
- 2079108-44-2
- INCMGA-00012
- MGA-012
- INCMGA00012
- INCMGA 00012
- MGA012
- MGA 012
- MGA-012
- PD-1/PD-L1
- PD-1/Programmed death-ligand 1
- Human epidermal growth factor receptor 2 (HER2)
- anti-programmed cell death protein 1 (anti-PD-1)
- monoclonal antibody (mAb)
- gastroesophageal adenocarcinoma (GEA)
- Inhibitor
- inhibitor
- inhibit