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Myristyl nicotinate (Synonyms: Tetradecyl nicotinate)

Cat. No.: HY-133027 Purity: >98.0%
Handling Instructions

Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier.

For research use only. We do not sell to patients.

Myristyl nicotinate Chemical Structure

Myristyl nicotinate Chemical Structure

CAS No. : 273203-62-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].

In Vitro

Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2].

Clinical Trial
Molecular Weight

319.48

Formula

C₂₀H₃₃NO₂

CAS No.

273203-62-6

SMILES

O=C(C1=CC=CN=C1)OCCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.62 mg/mL (30.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1301 mL 15.6504 mL 31.3009 mL
5 mM 0.6260 mL 3.1301 mL 6.2602 mL
10 mM 0.3130 mL 1.5650 mL 3.1301 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.96 mg/mL (3.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.96 mg/mL (3.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Myristyl nicotinateTetradecyl nicotinateOtherslipophilicderivativeesterprodrugskindeliveryNicotinic acidbarrierimpairmentInhibitorinhibitorinhibit

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Product name:
Myristyl nicotinate
Cat. No.:
HY-133027
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