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Seribantumab

(Synonyms: SAR 256212; MM 121)
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Based on 1 Customer Validation

Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models.

For research use only. We do not sell to patients.

  • Purity: 96.043%
  • CAS No.: 1334296-12-6
  • Molecular Weight:143.14 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Seribantumab
  • Experimental Validation Results for Seribantumab
  • Experimental Validation Results for Seribantumab
  • Seribantumab Chemical Structure
    Seribantumab Chemical Structure
CAS No.: 1334296-12-6
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Seribantumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG2 lambda

  • 1/16

    Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Seribantumab. The EC50 for this effect is 7.53 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells labeling Seribantumab (HY-P99268, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 lambda (HY-P991206, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Seribantumab Chemical Structure
    1/16
  • Seribantumab
  • Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Seribantumab. The EC50 for this effect is 7.53 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells labeling Seribantumab (HY-P99268, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 lambda (HY-P991206, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).