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Trastuzumab (anti-HER2)

(Synonyms: Anti-Human HER2, Humanized Antibody (anti-HER2))
66 Cited Publications
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Based on 66 publication(s) in Google Scholar

Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

For research use only. We do not sell to patients.

  • Purity: 99.838%
  • CAS No.: 180288-69-1
  • Molecular Weight:145.42 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Experimental Validation Results for Trastuzumab (anti-HER2)
  • Trastuzumab (anti-HER2) Chemical Structure
    Trastuzumab (anti-HER2) Chemical Structure
CAS No.: 180288-69-1
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Assay Types
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    Human IgG1 kappa

  • 1/16

    Loaded Her2/CD340 Protein, Human (Biotinylated, HEK293, His, HY-P78882) on AHC2 biosensor, can bind Trastuzumab with an affinity constant of 6.903E-10 M as determined in BLI assay.

  • 1/16

    Trastuzumab has a significant ADCC effect on BT474 cells in a dose-dependent manner.The EC50 for this effect is 26.36 and 32.09 ng/mL.

  • 1/16

    Trastuzumab has a significant ADCC effect on SK-BR-3 cells in a dose-dependent manner.The EC50 for this effect is 14.43 and 16.70 ng/mL.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 4;16(1):6152. [Abstract]

    Customer Validation
     ELISA analysis of same constructs with FcγRIIIA-V158 as immobilized antigen.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Mar 12;16(1):170. [Abstract]

    Customer Validation
     Trastuzumab (100 ng/mL; 24-94 h) significantly downregulated MCL1 protein levels in HER2-amplified NCI-N87 (Fig. A) and SNU-216 (Fig. B) cells, but shows no such effect in HER2-nonamplified GCIY cells (Fig. C).

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 14;14(1):5699. [Abstract]

    Customer Validation
     Trastuzumab (TZB) (3.16-1000 nM; 14 h) is cytotoxic to GBC-SD and EH-GB1 cells.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 26;11(1):1049. [Abstract]

    Customer Validation
     Trypsin microdroplet digestion of the therapeutic antibody Trastuzumab with ESSI-MS (−3 kV) after PAGE gel separation.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2020 Apr 10:475:53-64. [Abstract]

    Customer Validation
     Cell viability was measured for cells as in shControl or shEphB4 for 9 days by crystal violet assays.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2020 Apr 10:475:53-64. [Abstract]

    Customer Validation
     Western blot analysis of proteins as indicated in shControl or shEphB4 expressing HCC1954 cells treated with or without Transtuzumab (30 mg/mL) for 72 hours.

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2019 May 22;38(1):214. [Abstract]

    Customer Validation
     Tumours obtained from mice injected subcutaneously with HGC-27 cells with either over- or normal expression of GPAA1 and treated with vehicle or Trastuzumab (25 mg/kg, twice daily, 35 days).

  • 1/16

    Trastuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2019 May 22;38(1):214. [Abstract]

    Customer Validation
     IHC staining of GPAA1, p-AKT and Ki-67 in each group treated with vehicle or Trastuzumab (25 mg/kg, twice daily, 35 days).

  • Trastuzumab (anti-HER2) Chemical Structure
    1/16
  • Trastuzumab (anti-HER2)
  • Loaded Her2/CD340 Protein, Human (Biotinylated, HEK293, His, HY-P78882) on AHC2 biosensor, can bind Trastuzumab with an affinity constant of 6.903E-10 M as determined in BLI assay.
  • Trastuzumab has a significant ADCC effect on BT474 cells in a dose-dependent manner.The EC50 for this effect is 26.36 and 32.09 ng/mL.
  • Trastuzumab has a significant ADCC effect on SK-BR-3 cells in a dose-dependent manner.The EC50 for this effect is 14.43 and 16.70 ng/mL.