Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma

  • Signal Transduct Target Ther. 2020 Sep 14;5(1):200. doi: 10.1038/s41392-020-00309-1.
Juan Liu   #  1  2 ,  Qianmao Liang   #  1  2 ,  Aoli Wang   #  1  3 ,  Fengming Zou   #  1  3 ,  Ziping Qi  1  3 ,  Kailin Yu  1 ,  Qingwang Liu  1  3  4  5 ,  Cheng Chen  1  2  3 ,  Jing Liu  6  7  8 ,  Qingsong Liu  9  10  11  12  13  14
Affiliations
  • 1. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China.
  • 2. University of Science and Technology of China, 230036, Hefei, Anhui, P. R. China.
  • 3. Hefei Cancer Hospital, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China.
  • 4. Precision Medicine Research Laboratory of Anhui Province, 230088, Hefei, Anhui, P. R. China.
  • 5. Precision Targeted Therapy Discovery Center, Institute of Technology Innovation, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230088, Hefei, Anhui, P. R. China.
  • 6. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China. [email protected].
  • 7. University of Science and Technology of China, 230036, Hefei, Anhui, P. R. China. [email protected].
  • 8. Hefei Cancer Hospital, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China. [email protected].
  • 9. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China. [email protected].
  • 10. University of Science and Technology of China, 230036, Hefei, Anhui, P. R. China. [email protected].
  • 11. Hefei Cancer Hospital, Chinese Academy of Sciences, 230031, Hefei, Anhui, P. R. China. [email protected].
  • 12. Precision Medicine Research Laboratory of Anhui Province, 230088, Hefei, Anhui, P. R. China. [email protected].
  • 13. Precision Targeted Therapy Discovery Center, Institute of Technology Innovation, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230088, Hefei, Anhui, P. R. China. [email protected].
  • 14. Institutes of Physical Science and Information Technology, Anhui University, 230601, Hefei, Anhui, P. R. China. [email protected].
  • # Contributed equally.
PMID: 32929063 DOI: 10.1038/s41392-020-00309-1
Products