1. Inhibitory Antibodies
  2. Rituximab

Rituximab (Synonyms: Anti-Human CD20 type I, Chimeric Antibody)

Cat. No.: HY-P9913 Purity: 99.85%
Handling Instructions

Rituximab is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer.

For research use only. We do not sell to patients.

Rituximab Chemical Structure

Rituximab Chemical Structure

CAS No. : 174722-31-7

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Estimated Time of Arrival: December 31
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Description

Rituximab is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer.

In Vitro

Rituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab[1]. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells[2].

In Vivo

A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3].

Clinical Trial
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay

A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

C57BL/6 mice (8-10 wk of age) are inoculated 8×103 EL4-CD20+ cells in 200 μL of saline by tail vein injection. In parallel groups of mice, 150 g of rituximab, murine anti-CD20 IgG2a Ab 1F5, or control anti-human IL-2R Ab daclizumab in 300 μL of saline, or saline only is inoculated i.p. 24 h later[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

144544.44

CAS No.

174722-31-7

SMILES

[Rituximab]

Purity: 99.85%

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Rituximab
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HY-P9913
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Rituximab

Cat. No.: HY-P9913