MS4A1 - membrane spanning 4-domains A1 Gene

Also Known as B1; S7; Bp35; CD20; FMC7; CVID5; LEU-16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 931

About MS4A1

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,455,847-60,470,752 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 206.7), spleen (RPKM 109.2) and 2 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

MS4A1 Products (3)

mRNA	Protein	Name
NM_021950.4	NP_068769.2	B-lymphocyte antigen CD20
NM_152866.3	NP_690605.1	B-lymphocyte antigen CD20
NM_152867.2	NP_690606.1	B-lymphocyte antigen CD20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32792392	GOA
enables immunoglobulin binding	IDA IDA: Inferred from direct assay	18474602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell activation	IDA IDA: Inferred from direct assay	3925015	GOA
involved in B cell differentiation	IDA IDA: Inferred from direct assay	3925015	GOA
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18474602	GOA
involved in calcium ion import into cytosol	IDA IDA: Inferred from direct assay	7684739	GOA
involved in protein tetramerization	IDA IDA: Inferred from direct assay	7684739	GOA
involved in store-operated calcium entry	IMP IMP: Inferred from mutant phenotype	12920111	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	3925015	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23874341	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	12920111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A1 Protein Structure

CD20

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
B-lymphocyte antigen CD20	B-lymphocyte cell-surface antigen B1 CD20 antigen CD20 receptor leukocyte surface antigen Leu-16 membrane-spanning 4-domains, subfamily A, member 1

MS4A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MS4A1	P11836	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	MS4A1	P11836	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	MS4A1	P11836	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	REEP2	Homo sapiens	Q9BRK0	Validated Y2H	32296183
Intra	MS4A1	P11836	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	MS4A1	P11836	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	MS4A1	P11836	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	MS4A1	P11836	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	MS4A1	P11836	TSPO2	Homo sapiens	Q5TGU0	Y2H Array	32296183
Intra	MS4A1	P11836	TSPO2	Homo sapiens	Q5TGU0	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	TMEM72	Homo sapiens	A0PK05	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	TMEM72	Homo sapiens	A0PK05	Y2H Array	32296183
Intra	MS4A1	P11836	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	MS4A1	P11836	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	MS4A1	P11836	ACKR2	Homo sapiens	O00590	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	ACKR2	Homo sapiens	O00590	Y2H Array	32296183
Intra	MS4A1	P11836	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	MS4A1	P11836	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	MS4A1	P11836	FCRL3	Homo sapiens	Q96P31-6	Validated Y2H	32296183
Intra	MS4A1	P11836	FCRL3	Homo sapiens	Q96P31-6	Y2H Array	32296183
Intra	MS4A1	P11836	FCRL3	Homo sapiens	Q96P31-6	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	MS4A1	P11836	SLC18A1	Homo sapiens	P54219-3	Validated Y2H	32296183
Intra	MS4A1	P11836	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	MS4A1	P11836	CLEC14A	Homo sapiens	Q86T13	Validated Y2H	32296183
Intra	MS4A1	P11836	CLEC14A	Homo sapiens	Q86T13	Y2H Array	32296183
Intra	MS4A1	P11836	CLEC14A	Homo sapiens	Q86T13	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	MMD	Homo sapiens	Q15546	Validated Y2H	32296183
Intra	MS4A1	P11836	MMD	Homo sapiens	Q15546	Y2H Array	32296183
Intra	MS4A1	P11836	MMD	Homo sapiens	Q15546	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	MS4A1	P11836	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	MS4A1	P11836	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	MS4A1	P11836	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	MS4A1	P11836	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	MS4A1	P11836	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	MS4A1	P11836	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	MS4A1	P11836	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	MS4A1	P11836	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	MS4A1	P11836	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	MS4A1	P11836	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	MS4A1	P11836	ccsb orf id: 56912	Homo sapiens	EBI-23683148	Y2H Array	32296183
Intra	MS4A1	P11836	ccsb orf id: 56912	Homo sapiens	EBI-23683148	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	ccsb orf id: 2260	Homo sapiens	EBI-22326698	Y2H Array	32296183
Intra	MS4A1	P11836	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	ccsb orf id: 2260	Homo sapiens	EBI-22326698	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	MS4A1	P11836	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	MS4A1	P11836	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	MS4A1	P11836	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	MS4A1	P11836	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	MS4A1	P11836	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	MS4A1	P11836	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	MS4A1	P11836	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	MS4A1	P11836	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	MS4A1	P11836	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	MS4A1	P11836	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	MS4A1	P11836	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	MS4A1	P11836	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	MS4A1	P11836	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	MS4A1	P11836	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	MS4A1	P11836	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	MS4A1	P11836	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	MS4A1	P11836	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	MS4A1	P11836	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	MS4A1	P11836	IL7R	Homo sapiens	P16871	Y2H Prey Pooling	32296183
Intra	MS4A1	P11836	IL7R	Homo sapiens	P16871	Validated Y2H	32296183
Intra	MS4A1	P11836	IL7R	Homo sapiens	P16871	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MS4A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7896	CD20/MS4A1 Protein, Human (Trx-His, Solution)	P11836-1 (I141-S188)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78086	CD20/MS4A1 Protein, Human (His-Avi)	P11836-1 (I141-S188)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78543	CD20/MS4A1 Protein-VLP, Human (HEK293)	P11836-1 (M1-P297)	≥ 95%, as determined by HPLC.
HY-P7896A	CD20/MS4A1 Protein, Human (Trx-His)	P11836-1 (I141-S188)	≥ 95%, as determined by reducing SDS-PAGE.

MS4A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811364	CD20 Antibody	WB, FC, ELISA	Mouse
HY-P81558	CD20 Antibody (YA1303)	WB, IHC-P, FC	Human
HY-P86444	CD20 Antibody (YA6136)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Immunodeficiency, Common Variable, 5	CVID5 Antibody Deficiency Due To Cd20 Defect Immunodeficiency, Variable, Common, Type 5
Leukemia, Chronic Lymphocytic 2	Leukemia, Chronic Lymphocytic, Susceptibility To, 2 B-Cell Malignancy, Low-Grade Clls2 Disrupted In B-Cell Malignancy Dbm Leukemia, Chronic Lymphocytic, B-Cell Bcll Lymphocytic Leukemia Chronic B-Cell Chronic Lymphocytic Leukemia Chronic Lymph Leukaemia Chronic Lymphatic Leukaemia Chronic Lymphocytic Leukaemia Chronic Lymphoid Leukaemia Lymphoplasmacytic Leukaemia
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
B-Cell Non-Hodgkin Lymphoma	B-Cell Nhl B-Cell Non-Hodgkins Lymphoma
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Pityriasis Lichenoides
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990649	PF-5212374	Inhibitor	97.9%	Phase 2
HY-P99308	Ocaratuzumab	Inhibitor	95.00%	Phase 1
HY-P991671	Anafiltamig	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08696	MS4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08697	Ms4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08698	Ms4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18183	Ms4a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24657	Ms4a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990054	Eramkafusp Alfa		/	Unkown
HY-P992104	Blidarvetug	Inhibitor	/	Unkown
HY-P992144	Zareprumig	Inhibitor	/	Unkown
HY-P991546	MEDI-552	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MS4A1	VGNC	VGNC:74928
Felis catus	MS4A1	VGNC	VGNC:68321
Rattus norvegicus	MS4A1	RGD	RGD:1311999
Canis familiaris	MS4A1	VGNC	VGNC:52268
Bos taurus	MS4A1	VGNC	VGNC:31681
Mus musculus	MS4A1	MGD	MGI:88321
Others	MS4A1	NCBI