MS4A1 - membrane spanning 4-domains A1 Gene

Homo sapiens

Also known as B1; S7; Bp35; CD20; FMC7; CVID5; LEU-16

Gene ID: 931 | Gene type: protein coding

About MS4A1

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,455,847-60,470,752 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 206.7), spleen (RPKM 109.2) and 2 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

MS4A1 Products(3)

mRNA	Protein	Name
NM_021950.4	NP_068769.2	B-lymphocyte antigen CD20
NM_152866.3	NP_690605.1	B-lymphocyte antigen CD20
NM_152867.2	NP_690606.1	B-lymphocyte antigen CD20

MS4A1 Protein Structure

CD20

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

B-lymphocyte antigen CD20

B-lymphocyte cell-surface antigen B1	CD20 antigen
CD20 receptor	leukocyte surface antigen Leu-16
membrane-spanning 4-domains, subfamily A, member 1

Recombinant MS4A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7896	CD20/MS4A1 Protein, Human (Trx-His, Solution)	P11836 (I141-S188)	≥95%
HY-P78086	CD20/MS4A1 Protein, Human (His-Avi)	P11836 (I141-S188)	≥95%
HY-P78087	CD20/MS4A1 Protein-VLP, Human (Biotinylated, HEK293)	P11836 (M1-P297)	≥95%
HY-P78543	CD20/MS4A1 Protein-VLP, Human (HEK293)	P11836 (M1-P297)	≥95%
HY-P78835	CD20/MS4A1 Protein, Human (Biotinylated, His-Avi )	P11836 (M1-P297)	≥95%
HY-P700295	CD20 Protein, Human (Trx)	P11836/NP_068769.2 (I141-S188)	≥95%
HY-P7896A	CD20/MS4A1 Protein, Human (Trx-His)	P11836 (I141-S188)	≥95%

Related Diseases

Diseases

Alias

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Immunodeficiency, Common Variable, 5

CVID5	Antibody Deficiency Due To Cd20 Defect
Immunodeficiency, Variable, Common, Type 5

Leukemia, Chronic Lymphocytic 2

Leukemia, Chronic Lymphocytic, Susceptibility To, 2	B-Cell Malignancy, Low-Grade
Clls2	Disrupted In B-Cell Malignancy
Dbm	Leukemia, Chronic Lymphocytic, B-Cell
Bcll	Lymphocytic Leukemia Chronic B-Cell
Chronic Lymphocytic Leukemia	Chronic Lymph Leukaemia
Chronic Lymphatic Leukaemia	Chronic Lymphocytic Leukaemia
Chronic Lymphoid Leukaemia	Lymphoplasmacytic Leukaemia

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy	Lymphoplasmacytic Lymphoma
Waldenstrom'S Macroglobulinaemia	Waldenstrom'S Syndrome
Waldenström Macroglobulinemia	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Acquired Hypogammaglobulinemia	Common Variable Immune Deficiency
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease	BENTA
B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease	Persistent Polyclonal B-Cell Lymphocytosis
Lymphocytosis

Pityriasis Lichenoides

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Herpes Zoster

Shingles	Zoster
Herpes Zona	Herpes Zoster Disease
Zona Zoster	Herpes Zoster Of Skin And Mucous Membranes
Zoster Nos	Zoster With Nervous System Involvement

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency	IMD27B
Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant	Ifngr1 Deficiency, Autosomal Dominant
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27b, Mycobacteriosis, Ad
Autosomal Dominant Ifngr1 Deficiency	Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis
Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99308	Ocaratuzumab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08696	MS4A1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08697	Ms4a1 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08698	Ms4a1 Rat Pre-designed siRNA Set A	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990054	Eramkafusp Alfa		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MS4A1	VGNC	VGNC:74928
Felis catus	MS4A1	VGNC	VGNC:68321
Rattus norvegicus	MS4A1	RGD	RGD:1311999
Canis familiaris	MS4A1	VGNC	VGNC:52268
Bos taurus	MS4A1	VGNC	VGNC:31681
Mus musculus	MS4A1	MGD	MGI:88321
Macaca fascicularis	MS4A1	NCBI	NCBI:102118491
Canis lupus familiaris	MS4A1	NCBI
Others	MS4A1	NCBI

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