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Cat. No.: HY-P811364

CD20 Antibody

Name: CD20 Antibody
Brand: MedChemExpress
SKU: HY-P811364
Availability: PreOrder

(Synonyms: Bp35, MS4A1)

CD20 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CD20.

For research use only. We do not sell to patients.

Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

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Quantity

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-2000	1μg /Test	1:5000-10000

Description

CD20 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CD20.

Host Rabbit
Clonality Polyclonal
Species Reactivity
Mouse Predicted Reactivity: Human,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 43 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 43 kDa

Sensitivity

Endogenous

Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Solution
Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

CD20 is a 33-37 kDa non-glycosylated protein expressed specifically on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 is a general B-cell marker expressed by the majority of B cells starting from late pre-B lymphocytes (it is not expressed by pro-B lymphocytes), and its expression is lost in terminally differentiated plasmablasts and plasma cells. Early experiments suggested that it was important in the regulation of human B-cell activation, proliferation, and Ca²⁺ transport. However, CD20-deficient mice appeared normal. Hence, the exact biological function of CD20 and its physiological ligand remain to be fully defined.240 Regardless of the uncertainty in the biological role of this antigen, it is a good target for cancer immunotherapy.
Subcellular Localization

Cell membrane; Multi-pass membrane protein; Cell membrane; Lipid-anchor
Expression

Tissue_specificity:Expressed on B cells
Isoforms & Post-Translational Modification

P11836 has 2 isomers: P11836-1: 33077 Da (predicted); P11836-2: 14581 Da (predicted).
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate
Subunit

Forms homotetramers (PubMed:18474602, PubMed:7684739). Interacts with the heavy and light chains of cell surface IgM, the antigen-binding components of the BCR (PubMed:18474602)
Gene ID

931 [NCBI]
Synonyms

Bp35, MS4A1
Research Field

Cell biology