SLC10A1 - solute carrier family 10 member 1 Gene

Also Known as NTCP; FHCA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6554

About SLC10A1

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,775,416-69,797,241 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues, 5 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 124.7).

Summary

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of Cholesterol metabolism, hence this protein is important for Cholesterol homeostasis. [provided by RefSeq, Oct 2011]

SLC10A1 Products (1)

mRNA	Protein	Name
NM_003049.4	NP_003040.1	hepatic sodium/bile acid cotransporter

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC10A1 Protein Structure

SBF

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
hepatic sodium/bile acid cotransporter	Na(+)/bile acid cotransporter

SLC10A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC10A1	Q14973	SLC25A46	Homo sapiens	Q96AG3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TOMM6	Homo sapiens	Q96B49	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ORMDL2	Homo sapiens	Q53FV1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TVP23B	Homo sapiens	Q9NYZ1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	SLC10A1	Q14973	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM121	Homo sapiens	Q9BTD3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	IFITM2	Homo sapiens	Q6IBB0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC16A13	Homo sapiens	Q7RTY0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	OTOP3	Homo sapiens	Q7RTS5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC12A7	Homo sapiens	Q9Y666-2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC35E4	Homo sapiens	Q6ICL7	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC7A3	Homo sapiens	Q8WY07	Validated Y2H	32296183
Intra	SLC10A1	Q14973	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ARL6IP6	Homo sapiens	Q8N6S5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMUB2	Homo sapiens	Q71RG4	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMBIM1	Homo sapiens	Q969X1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	GDE1	Homo sapiens	Q9NZC3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	COX20	Homo sapiens	Q5RI15	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SFT2D1	Homo sapiens	Q8WV19	Validated Y2H	32296183
Intra	SLC10A1	Q14973	q96fb2_human	Homo sapiens	Q96FB2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ACSL5	Homo sapiens	Q9ULC5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SFXN1	Homo sapiens	Q9H9B4	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC66A2	Homo sapiens	Q8N2U9	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	DERL1	Homo sapiens	Q9BUN8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SCAMP4	Homo sapiens	Q969E2	Validated Y2H	32296183
Intra	SLC10A1	Q14973	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	SLC10A1	Q14973	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	SLC10A1	Q14973	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	SLC10A1	Q14973	ORMDL3	Homo sapiens	Q8N138	Validated Y2H	32296183
Intra	SLC10A1	Q14973	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	SLC10A1	Q14973	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	SLC10A1	Q14973	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	SLC10A1	Q14973	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	TMEM234	Homo sapiens	Q8WY98	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Intra	SLC10A1	Q14973	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183
Intra	SLC10A1	Q14973	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC10A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811318	NTCP Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypercholanemia, Familial, 2	FHCA2 Ntcp Deficiency Hypercholanemia, Familial 2 Ntcpd
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Biliary Atresia	Congenital Biliary Atresia Isolated Biliary Atresia Isolated Atresia Of Bile Ducts Non-Syndromic Biliary Atresia Atresia Of Bile Duct Biliary Atresia, Congenital Atresia Of Bile Ducts Bile Duct Atresia Congenital Bile Duct Atresia Ba - [Biliary Atresia] Impervious Bile Duct Atresia Of Common Duct Biliary Duct Atresia Bile Ductal Atresia Cystic Duct Atresia
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Hepatoblastoma
Cholestasis, Benign Recurrent Intrahepatic, 1	Benign Recurrent Intrahepatic Cholestasis BRIC1 Summerskill Syndrome Bric Summerskill-Walshe-Tygstrup Syndrome Cholestasis, Benign Recurrent Intrahepatic Benign Recurrent Intrahepatic Cholestasis 1 Benign Recurrent Intrahepatic Cholestasis Type 1 Bric Type 1 Low Gamma-Gt Familial Intrahepatic Cholestasis Recurrent Familial Intrahepatic Cholestasis Cholestasis, Benign Recurrent Intrahepatic 1 Mild Atp8b1 Deficiency Recurrent Familial Intrahepatic Cholestasis 1 Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Cholestasis, Intrahepatic, Recurrent, Benign, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3 Bric - [Benign Recurrent Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 2	PFIC2 Cholestasis, Progressive Familial Intrahepatic 2 Progressive Familial Intrahepatic Cholestasis Type 2 Progressive Familial Intrahepatic Cholestasis 2 Bsep Deficiency Recurrent Familial Intrahepatic Cholestasis 2 Benign Recurrent Intrahepatic Cholestasis 2 Severe Abcb11 Deficiency Bric2 Cholestasis, Benign Recurrent Intrahepatic 2 Mild Abcb11 Deficiency Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Bile Acid Synthesis Defect, Congenital, 2	Cholestasis With Delta(4)-3-Oxosteroid 5-Beta-Reductase Deficiency CBAS2 Congenital Bile Acid Synthesis Defect 2 Congenital Bile Acid Synthesis Defect Type 2 Congenital Bile Acid Synthesis Defect, Type 2 Basd2 Bile Acid Synthesis Defect, Congenital, Type 2
Pericholangitis
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Hepatitis D	Delta Hepatitis Hepatitis Delta Hdv Hepatitis D Virus Hepatitis D Infection
Progressive Familial Intrahepatic Cholestasis	Abcb4-Related Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic Pfic Byler Disease Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Bsep Deficiency Byler Disease Byler Syndrome Fic1 Deficiency Low Γ-Gt Familial Intrahepatic Cholestasis Mdr3 Deficiency Pfic Cholestasis, Intrahepatic, Familial, Progressive Pfic - [Progressive Familial Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 3	PFIC3 Cholestasis, Progressive Familial Intrahepatic 3 Mdr3 Deficiency Progressive Familial Intrahepatic Cholestasis Type 3 Progressive Familial Intrahepatic Cholestasis 3 Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase Cholestasis, Intrahepatic, Familial, Progressive, Type 3
Extrahepatic Cholestasis	Cholestasis, Extrahepatic Extrahepatic Biliary Stasis Extrahepatic Obstructive Biliary Disease Cholestasis Extrahepatic
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Cholestasis, Progressive Familial Intrahepatic, 1	PFIC1 Byler Disease Cholestasis, Progressive Familial Intrahepatic 1 Progressive Familial Intrahepatic Cholestasis 1 Progressive Familial Intrahepatic Cholestasis Type 1 Fic1 Deficiency Byler'S Disease Cholestasis, Fatal Intrahepatic Progressive Familial Intrahepatic Cholestasis Severe Atp8b1 Deficiency Fatal Intrahepatic Cholestasis Cholestasis, Intrahepatic, Familial, Progressive, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Bile Duct Disease	Bile Duct Diseases Bile Duct Disorder Disorder Of Bile Duct
Biliary Tract Disease	Biliary Tract Diseases Biliary Tract Abnormality
Sclerosing Cholangitis	Fibrosing Cholangitis Cholangitis, Sclerosing Primary Sclerosing Cholangitis
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12985	SLC10A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22028	Slc10a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC10A1	VGNC	VGNC:65180
Bos taurus	SLC10A1	VGNC	VGNC:34659
Canis familiaris	SLC10A1	VGNC	VGNC:46211
Rattus norvegicus	SLC10A1	RGD	RGD:3681
Macaca mulatta	SLC10A1	VGNC	VGNC:77380
Mus musculus	SLC10A1	MGD	MGI:97379
Others	SLC10A1	NCBI