SLC7A3 - solute carrier family 7 member 3 Gene

Also Known as CAT3; ATRC3; CAT-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84889

About SLC7A3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,925,579-70,931,096 (from NCBI)

This gene has 2 transcripts (splice variants), 343 orthologues and 12 paralogues. Biased expression in endometrium (RPKM 1.9), prostate (RPKM 1.2) and 8 other tissues.

Summary

This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic Amino acid Transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

SLC7A3 Products (2)

mRNA	Protein	Name
NM_001048164.3	NP_001041629.1	cationic amino acid transporter 3
NM_032803.6	NP_116192.4	cationic amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-arginine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11591158	GOA
enables L-lysine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11591158	GOA
enables L-ornithine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11591158	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-arginine import across plasma membrane	IDA IDA: Inferred from direct assay	11591158	GOA
involved in L-lysine import across plasma membrane	IDA IDA: Inferred from direct assay	11591158	GOA
involved in L-ornithine import across plasma membrane	IDA IDA: Inferred from direct assay	11591158	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11591158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A3 Protein Structure

AA_permease_2

AA_permease_C

0
100
200
300
400
500
619 a.a.

Protein Preferred Names	Protein Names
cationic amino acid transporter 3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

SLC7A3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC7A3	Q8WY07	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	SLC7A3	Q8WY07	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC7A3	Q8WY07	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC7A3	Q8WY07	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SLC7A3	Q8WY07	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC7A3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84694	SLC7A3 Antibody (YA4391)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84694A	SLC7A3 Antibody (YA4391)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Congenital Aphakia	Congenital Absence Of Lens Aphakia, Congenital Primary Agenesis Of Lens
Alcoholic Ketoacidosis
Chromophobe Adenoma	Adenoma, Chromophobe Chromophobe Adenoma Of The Pituitary Gland Adenoma Chromophobe
Cornea Plana	Flat Cornea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13329	SLC7A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC7A3	VGNC	VGNC:77630
Rattus norvegicus	SLC7A3	RGD	RGD:68342
Bos taurus	SLC7A3	VGNC	VGNC:34929
Mus musculus	SLC7A3	MGD	MGI:1100521