AGPAT3 - 1-acylglycerol-3-phosphate O-acyltransferase 3 Gene

Also Known as LPAAT3; LPLAT3; 1-AGPAT 3; LPAAT-GAMMA1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 56894

About AGPAT3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:43,865,223-43,987,592 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues.

Summary

The protein encoded by this gene is an Acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AGPAT3 Products (5)

mRNA Protein Name
NM_001037553.2 NP_001032642.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369878.1 NP_001356807.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369880.1 NP_001356809.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369881.1 NP_001356810.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2
NM_020132.5 NP_064517.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
21173190 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21173190 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
21173190 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT3 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (83 - 230)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

  • 1-AGP acyltransferase 3

AGPAT3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
AGPAT3 Q9NRZ7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
AGPAT3 Q9NRZ7 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS00458 AGPAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus AGPAT3 RGD RGD:1305787
Canis familiaris AGPAT3 VGNC VGNC:37712
Felis catus AGPAT3 VGNC VGNC:59686
Macaca mulatta AGPAT3 VGNC VGNC:84744
Mus musculus AGPAT3 MGD MGI:1336186
Bos taurus AGPAT3 VGNC VGNC:25736
Others AGPAT3 NCBI