ATP6V0B - ATPase H+ transporting V0 subunit b Gene

Homo sapiens

Also known as ATP6F; HATPL; VMA16

Gene ID: 533 | Gene type: protein coding

About ATP6V0B

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,974,960-43,978,295 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 52.4), kidney (RPKM 31.0) and 25 other tissues.

Summary

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this Enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ATP6V0B Products(3)

mRNA	Protein	Name
NM_001039457.3	NP_001034546.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 2
NM_001294333.2	NP_001281262.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 3
NM_004047.5	NP_004038.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1

ATP6V0B Protein Structure

ATP-synt_C

0
100
205 a.a.

Protein Preferred Names

Protein Names

V-type proton ATPase 21 kDa proteolipid subunit c''

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01219	ATP6V0B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP6V0B	MGD	MGI:1890510
Felis catus	ATP6V0B	VGNC	VGNC:68695
Rattus norvegicus	ATP6V0B	RGD	RGD:1308303
Bos taurus	ATP6V0B	VGNC	VGNC:26310
Canis familiaris	ATP6V0B	VGNC	VGNC:38271
Macaca mulatta	ATP6V0B	VGNC	VGNC:70187

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