GPR61 - G protein-coupled receptor 61 Gene

Also Known as BALGR; GPCR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83873

About GPR61

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,539,872-109,547,260 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues and 3 paralogues. Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues.

Summary

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

GPR61 Products (2)

mRNA Protein Name
NM_001393907.1 NP_001380836.1 G-protein coupled receptor 61
NM_031936.6 NP_114142.3 G-protein coupled receptor 61

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arrestin family protein binding IDA
IDA: Inferred from direct assay
28827538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28827538 GOA
Biological Process GO Annotation Evidence References Source
involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28827538 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
28827538 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28827538 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR61 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 341)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 451 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 61

  • biogenic amine receptor-like G-protein coupled receptor

GPR61 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR61 Q9BZJ8 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
GPR61 Q9BZJ8 SLC12A7 Homo sapiens Q9Y666-2
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 SLC12A7 Homo sapiens Q9Y666-2
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 SLC12A7 Homo sapiens Q9Y666-2
Validated Y2H
32296183
Intra
GPR61 Q9BZJ8 GJB6 Homo sapiens O95452
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 GJB6 Homo sapiens O95452
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
GPR61 Q9BZJ8 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 ARL6IP6 Homo sapiens Q8N6S5
Y2H Array
32296183
Intra
GPR61 Q9BZJ8 ARL6IP6 Homo sapiens Q8N6S5
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
GPR61 Q9BZJ8 CLDND1 Homo sapiens Q9NY35
Validated Y2H
32296183
Intra
GPR61 Q9BZJ8 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
GPR61 Q9BZJ8 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Olfactory Groove Meningioma

  • Meningioma Of The Olfactory Groove
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156354 GPR61 Inverse agonist 1 Inhibitor 98.24% Unkown
HY-182270 GPR61 Inverse agonist 2 Antagonist / Unkown
HY-182271 GPR61 Inverse agonist 3 Inhibitor / Unkown
HY-RS05727 GPR61 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20943 Gpr61 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27460 Gpr61 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR61 VGNC VGNC:54028
Macaca mulatta GPR61 VGNC VGNC:72933
Felis catus GPR61 VGNC VGNC:62692
Bos taurus GPR61 VGNC VGNC:29593
Rattus norvegicus GPR61 RGD RGD:1310176
Mus musculus GPR61 MGD MGI:2441719
Others GPR61 NCBI