CLDND1 - claudin domain containing 1 Gene

Also Known as Z38; C3orf4; GENX-3745

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56650

About CLDND1

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:98,515,483-98,522,902 (from NCBI)

This gene has 31 transcripts (splice variants) and 286 orthologues. Broad expression in brain (RPKM 128.7), testis (RPKM 51.4) and 23 other tissues.

Summary

Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

CLDND1 Products (6)

mRNA Protein Name
NM_001040181.2 NP_001035271.1 claudin domain-containing protein 1 isoform a
NM_001040182.2 NP_001035272.1 claudin domain-containing protein 1 isoform b
NM_001040183.2 NP_001035273.1 claudin domain-containing protein 1 isoform a
NM_001040199.2 NP_001035289.1 claudin domain-containing protein 1 isoform a
NM_001040200.2 NP_001035290.1 claudin domain-containing protein 1 isoform d
NM_019895.3 NP_063948.1 claudin domain-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDND1 Protein Structure

Claudin_2

Claudin_2: PMP-22/EMP/MP20/Claudin tight junction (18 - 234)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

claudin domain-containing protein 1

  • claudin domain containing 1 protein

CLDND1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLDND1 Q9NY35 GPR61 Homo sapiens Q9BZJ8
Y2H Prey Pooling
32296183
Intra
CLDND1 Q9NY35 GPR61 Homo sapiens Q9BZJ8
Y2H Array
32296183
Intra
CLDND1 Q9NY35 ZDHHC4 Homo sapiens Q9NPG8
Y2H Prey Pooling
32296183
Intra
CLDND1 Q9NY35 ZDHHC4 Homo sapiens Q9NPG8
Y2H Array
32296183
Intra
CLDND1 Q9NY35 CXCR1 Homo sapiens P25024
Y2H Array
32296183
Intra
CLDND1 Q9NY35 CXCR1 Homo sapiens P25024
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Inflammatory Bowel Disease 17

  • Inflammatory Bowel Disease 17, Protection Against

  • IBD17

  • Bowel Disease, Inflammatory, Type 17
Cardiomyopathy, Familial Restrictive, 2

  • RCM2

  • Restrictive Cardiomyopathy 2

  • Familial Restrictive Cardiomyopathy 2

  • Cardiomyopathy, Restrictive, Familial, Type 2
3-Methylglutaconic Aciduria, Type I

  • 3-Methylglutaconyl-Coa Hydratase Deficiency

  • 3-Methylglutaconic Aciduria Type 1

  • Mga1

  • MGCA1

  • 3mg-Coa Hydratase Deficiency

  • Mga Type I

  • Mga, Type I

  • 3-Mg-Coa-Hydratase Deficiency

  • 3 Methylglutaconyl Coa Hydratase Deficiency

  • 3-Methylglutaconic Aciduria Type I

  • 3 Alpha Methylglutaconic Aciduria Type I

  • 3 Methylglutaconic Aciduria Type 1

  • 3-Mgca Type I

  • 3mg Coa Hydratase Deficiency

  • Auh Defect

  • Primary 3-Methylglutaconic Aciduria

  • 3-Methylglutaconic Aciduria 1

  • 3-Alpha-Methylglutaconic Aciduria Type 1

  • 3-Alpha-Methylglutaconyl-Coa Hydratase Deficiency

  • 3-@Methylglutaconic Aciduria, Type I

  • Megaloblastic Anemia Due To Inborn Errors Of Metabolism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02778 CLDND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLDND1 VGNC VGNC:39324
Bos taurus CLDND1 VGNC VGNC:27421
Mus musculus CLDND1 MGD MGI:2447860
Rattus norvegicus CLDND1 RGD RGD:1359273
Macaca mulatta CLDND1 VGNC VGNC:71169
Felis catus CLDND1 VGNC VGNC:82468
Others CLDND1 NCBI