2. Gene
  3. INSIG2 - insulin induced gene 2 Gene

INSIG2 - insulin induced gene 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INSIG-2

Gene ID: 51141 | Gene type: protein coding

About INSIG2

Cytogenetic location: 2q14.1-q14.2 Genomic coordinates (GRCh38): 2:118,088,471-118,110,997 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

INSIG2 Products(6)

mRNA Protein Name
NM_001321329.2 NP_001308258.1 insulin-induced gene 2 protein isoform a
NM_001321330.2 NP_001308259.1 insulin-induced gene 2 protein isoform b
NM_001321331.2 NP_001308260.1 insulin-induced gene 2 protein isoform b
NM_001321332.2 NP_001308261.1 insulin-induced gene 2 protein isoform b
NM_001321333.2 NP_001308262.1 insulin-induced gene 2 protein isoform c
NM_016133.4 NP_057217.2 insulin-induced gene 2 protein isoform a

INSIG2 Protein Structure

INSIG

INSIG: Insulin-induced protein (INSIG) (29 - 211)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

insulin-induced gene 2 protein

INSIG2 membrane protein

Related Diseases

Diseases Alias
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Leptin

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06838 INSIG2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta INSIG2 VGNC VGNC:73632
Bos taurus INSIG2 VGNC VGNC:30218
Rattus norvegicus INSIG2 RGD RGD:631417
Canis familiaris INSIG2 VGNC VGNC:42040
Mus musculus INSIG2 MGD MGI:1920249
Felis catus INSIG2 VGNC VGNC:62933
Others INSIG2 NCBI