EBP - EBP cholestenol delta-isomerase Gene

Also Known as CPX; CHO2; CPXD; MEND; CDPX2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10682

About EBP

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,521,808-48,528,716 (from NCBI)

This gene has 6 transcripts (splice variants), 189 orthologues, 1 paralogue and is associated with 5 phenotypes. Ubiquitous expression in liver (RPKM 87.3), duodenum (RPKM 37.6) and 24 other tissues.

Summary

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with Bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]

EBP Products (1)

mRNA	Protein	Name
NM_006579.3	NP_006570.1	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA
enables steroid delta-isomerase activity	EXP EXP: Inferred from Experiment	10391218	GOA
enables steroid delta-isomerase activity	IDA IDA: Inferred from direct assay	9894009	GOA
enables steroid delta-isomerase activity	IMP IMP: Inferred from mutant phenotype	10391219	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	9894009	GOA
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	10391219	GOA
involved in ossification involved in bone maturation	IMP IMP: Inferred from mutant phenotype	10391219	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10406945	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	10406945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBP Protein Structure

EBP

0
100
200
230 a.a.

Protein Preferred Names	Protein Names
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	3-beta-hydroxysteroid-delta-8,delta-7-isomerase

EBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EBP	Q15125	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	EBP	Q15125	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	EBP	Q15125	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	EBP	Q15125	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
Intra	EBP	Q15125	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	EBP	Q15125	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM199	Homo sapiens	Q8N511	Validated Y2H	32296183
Intra	EBP	Q15125	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	EBP	Q15125	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	EBP	Q15125	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	EBP	Q15125	DEFB127	Homo sapiens	Q9H1M4	Validated Y2H	32296183
Intra	EBP	Q15125	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	EBP	Q15125	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	EBP	Q15125	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	EBP	Q15125	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	EBP	Q15125	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	EBP	Q15125	ORMDL2	Homo sapiens	Q53FV1	Validated Y2H	32296183
Intra	EBP	Q15125	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	EBP	Q15125	TLCD1	Homo sapiens	Q96CP7	Validated Y2H	32296183
Intra	EBP	Q15125	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	EBP	Q15125	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	EBP	Q15125	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	EBP	Q15125	ARV1	Homo sapiens	Q9H2C2	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	EBP	Q15125	SNORC	Homo sapiens	Q6UX34	Validated Y2H	32296183
Intra	EBP	Q15125	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	EBP	Q15125	C5orf46	Homo sapiens	Q6UWT4	Validated Y2H	32296183
Intra	EBP	Q15125	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	EBP	Q15125	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM42	Homo sapiens	Q69YG0	Validated Y2H	32296183
Intra	EBP	Q15125	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	EBP	Q15125	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	EBP	Q15125	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	EBP	Q15125	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	EBP	Q15125	FAXDC2	Homo sapiens	Q96IV6	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	EBP	Q15125	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	EBP	Q15125	SLC48A1	Homo sapiens	Q6P1K1	Validated Y2H	32296183
Intra	EBP	Q15125	LTC4S	Homo sapiens	Q16873	Validated Y2H	32296183
Intra	EBP	Q15125	LEMD1	Homo sapiens	Q68G75	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	EBP	Q15125	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	EBP	Q15125	ODF4	Homo sapiens	Q2M2E3	Validated Y2H	32296183
Intra	EBP	Q15125	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
Intra	EBP	Q15125	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	NDUFB11	Homo sapiens	Q9NX14	Validated Y2H	32296183
Intra	EBP	Q15125	OTOP3	Homo sapiens	Q7RTS5	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM208	Homo sapiens	Q9BTX3	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	EBP	Q15125	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	EBP	Q15125	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	EBP	Q15125	FETUB	Homo sapiens	Q9UGM5	Validated Y2H	32296183
Intra	EBP	Q15125	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	EBP	Q15125	SYS1	Homo sapiens	Q8N2H4	Validated Y2H	32296183
Intra	EBP	Q15125	SLC35G1	Homo sapiens	Q2M3R5	Validated Y2H	32296183
Intra	EBP	Q15125	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	EBP	Q15125	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	EBP	Q15125	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	EBP	Q15125	SFXN5	Homo sapiens	Q8TD22	Validated Y2H	32296183
Intra	EBP	Q15125	CHODL	Homo sapiens	Q9H9P2	Validated Y2H	32296183
Intra	EBP	Q15125	CHODL	Homo sapiens	Q9H9P2	Y2H Array	32296183
Intra	EBP	Q15125	CHODL	Homo sapiens	Q9H9P2	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	EBP	Q15125	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	EBP	Q15125	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	EBP	Q15125	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	EBP	Q15125	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	EBP	Q15125	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	RNF152	Homo sapiens	Q8N8N0	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	EBP	Q15125	STX12	Homo sapiens	Q86Y82	Validated Y2H	32296183
Intra	EBP	Q15125	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	EBP	Q15125	ARL6IP6	Homo sapiens	Q8N6S5	Validated Y2H	32296183
Intra	EBP	Q15125	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	EBP	Q15125	EMC6	Homo sapiens	Q9BV81	Validated Y2H	32296183
Intra	EBP	Q15125	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	EBP	Q15125	CD69	Homo sapiens	Q07108	Y2H Array	32296183
Intra	EBP	Q15125	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	EBP	Q15125	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	EBP	Q15125	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	EBP	Q15125	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	EBP	Q15125	LRRC59	Homo sapiens	Q96AG4	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	LRRC59	Homo sapiens	Q96AG4	Validated Y2H	32296183
Intra	EBP	Q15125	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	EBP	Q15125	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	EBP	Q15125	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	EBP	Q15125	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	EBP	Q15125	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	EBP	Q15125	LPCAT2	Homo sapiens	Q7L5N7	Validated Y2H	32296183
Intra	EBP	Q15125	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	EBP	Q15125	SCAMP4	Homo sapiens	Q969E2	Validated Y2H	32296183
Intra	EBP	Q15125	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	EBP	Q15125	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	EBP	Q15125	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	EBP	Q15125	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	EBP	Q15125	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	EBP	Q15125	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	EBP	Q15125	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	EBP	Q15125	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	EBP	Q15125	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	EBP	Q15125	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	EBP	Q15125	FUNDC2	Homo sapiens	Q9BWH2	Validated Y2H	32296183
Intra	EBP	Q15125	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	EBP	Q15125	ORMDL3	Homo sapiens	Q8N138	Validated Y2H	32296183
Intra	EBP	Q15125	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	EBP	Q15125	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	EBP	Q15125	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	EBP	Q15125	STX8	Homo sapiens	Q9UNK0	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TMEM120A	Homo sapiens	Q9BXJ8	Validated Y2H	32296183
Intra	EBP	Q15125	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	EBP	Q15125	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	EBP	Q15125	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	EBP	Q15125	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	EBP	Q15125	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	EBP	Q15125	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	EBP	Q15125	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	EBP	Q15125	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	EBP	Q15125	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	EBP	Q15125	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	EBP	Q15125	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	EBP	Q15125	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	EBP	Q15125	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	EBP	Q15125	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	EBP	Q15125	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	EBP	Q15125	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	EBP	Q15125	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
Intra	EBP	Q15125	TBC1D20	Homo sapiens	Q96BZ9	Validated Y2H	32296183
Intra	EBP	Q15125	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mend Syndrome	Male Ebp Disorder With Neurological Defects MEND Male Ebp Disorder With Neurologic Defects
Chondrodysplasia Punctata 2, X-Linked Dominant	CDPX2 Happle Syndrome Chondrodysplasia Punctata, X-Linked Dominant Cdpxd Cpxd Conradi-Hunermann Syndrome Conradi-Hunermann-Happle Syndrome Chondrodysplasia Punctata 2 X-Linked Dominant X-Linked Dominant Chondrodysplasia Punctata 2 Conrad Hunermann Happle Syndrome Conradi Hunermann Syndrome Chh Chondrodysplasia Punctata, Type 2, X-Linked Dominant Chondrodysplasia Punctata, X-Linked Dominant Type Chondrodysplasia Punctata
X-Linked Chondrodysplasia Punctata 2	Happle Syndrome Cdpx2 Conradi-Hünermann Syndrome Chondrodysplasia Punctata 2, X-Linked X-Linked Dominant Chondrodysplasia Punctata Conradi-Hunermann Syndrome Conradi-Hünermann-Happle Syndrome Cdpxd Cpxd Chondrodystrophia Calcificans Congenita Conradi-Hunermann-Happle Syndrome X-Linked Chondrodysplasia Punctata Type 2 Chondrodysplasia Punctata, X-Linked Dominant Type
Chondrodysplasia Punctata Syndrome	Chondrodysplasia Punctata Chondrodysplasia Punctata Congenita Toriello Higgins Miller Syndrome Chondrodysplasia Punctata, Toriello Type Toriello-Higgins-Miller Syndrome Cdp Chondrodysplasia Punctata, X-Linked Dominant Type Chondrodysplasia Punctata Group Dysplasia Punctata Epiphysis Dysplasia Punctata Dysplasia Epiphysealis Punctata Chondrodystrophy Of Punctata
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects	Child Syndrome Ichthyosiform Erythroderma, Unilateral, With Ipsilateral Malformations, Especially Absence Deformity Of Limbs Child Nevus Congenital Hemidysplasia With Ichthyosiform Nevus And Limbs Defects Congenital Hemidysplasia With Ichthyosiform Nevus And Limb Defects Ichthyosis, Child Syndrome Child Syndrome Ichthyosis CHILD
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
X-Linked Chondrodysplasia Punctata 1	Chondrodysplasia Punctata 1, X-Linked Arylsulfatase E Deficiency Chondrodystrophia Calcificans Congenita Cdpx1 X-Linked Recessive Chondrodysplasia Punctata 1 Brachytelephalangic Chondrodysplasia Punctata
Greenberg Dysplasia	Hem Dysplasia Greenberg Skeletal Dysplasia Hem Skeletal Dysplasia GRBGD Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia Moth-Eaten Skeletal Dysplasia Chondrodystrophy, Hydropic And Prenatally Lethal Type Hydrops-Ectopic Calcification-Motheaten Syndrome Skeletal Dysplasia, Greenberg Type Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia Hem Hem/Greenberg Dysplasia Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Ck Syndrome	CKS X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation
Toxicodendron Dermatitis	Dermatitis, Toxicodendron Contact Dermatitis Due To Genus Toxicodendron Rhus Dermatitis Dermatitis Toxicodendron
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Facial Neuralgia
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Smith-Lemli-Opitz Syndrome	SLOS Rsh Syndrome 7-Dehydrocholesterol Reductase Deficiency Slo Syndrome Rutledge Lethal Multiple Congenital Anomaly Syndrome Lethal Acrodysgenital Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung Smith-Opitz-Inborn Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung Smith Lemli Opitz Syndrome Smith-Lemli-Opitz Syndrome, Type Ii
Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0660	Eicosapentaenoic Acid	Activator	98.09%	Yes
HY-10466	Daclatasvir	Inhibitor	99.57%	Unkown
HY-10465	Daclatasvir dihydrochloride	Inhibitor	99.82%	Unkown
HY-10237	Boceprevir	Inhibitor	98.52%	Unkown
HY-W011269	Eicosapentaenoic Acid sodium	Activator	95.78%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132607A	MTL-CEBPA sodium		91.62%	Phase 2
HY-132607	MTL-CEBPA		95.52%	Phase 2
HY-13766	Timcodar	Inhibitor	99.66%	Phase 2
HY-132168	RMC-5552	Inhibitor	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (81)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110188	BiP inducer X	Inhibitor	99.62%	Unkown
HY-N4103	Fucosterol	Inhibitor	98.27%	Unkown
HY-12461	WS6		99.09%	Unkown
HY-164561	TASIN-30		99.96%	Unkown
HY-116572A	TASIN-1		98.09%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-162351	EBP-IN-1	Inhibitor	99.77%	Unkown
HY-N1677	2,6-Dimethoxy-1,4-benzoquinone		98.72%	Unkown
HY-N6954	Garcinone C		99.51%	Unkown
HY-N0777	Isorhamnetin-3-O-glucoside		99.96%	Unkown
HY-12462	WS3		98.70%	Unkown
HY-N0656A	(+)-Usnic acid		99.64%	Unkown
HY-N4177	Rubrofusarin gentiobioside	Inhibitor	99.07%	Unkown
HY-114519	Helenalin acetate	Inhibitor	99.55%	Unkown
HY-134334	C/EBPα inducer 1		99.82%	Unkown
HY-115590	JP-11646		98.74%	Unkown
HY-N14035	Garcinia cambogia extract	Activator	/	Unkown
HY-134333	ICCB280	Activator	98.14%	Unkown
HY-143510	RMC-4627		99.20%	Unkown
HY-128671	6-Thioinosine		99.31%	Unkown
HY-P5275	Tripeptide-41		99.30%	Unkown
HY-W348485	WRX606	Inhibitor	95.65%	Unkown
HY-130723A	AMPK activator 2 hydrochloride	Activator	99.68%	Unkown
HY-134903	(32-Carbonyl)-RMC-5552	Inhibitor	95.41%	Unkown
HY-N11709	Theasaponin E1		98.68%	Unkown
HY-P10323A	T7 Peptide TFA		98.20%	Unkown
HY-114267	Cbz-B3A	Inhibitor	98.63%	Unkown
HY-176761	NSC647889		99.28%	Unkown
HY-N15574	Saringosterol		≥90.0%	Unkown
HY-RS04277	EIF4EBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W412264	Pim-1/2 kinase inhibitor 1	Inhibitor	99.78%	Unkown
HY-124348	DM-PIT-1	Inhibitor	99.9%	Unkown
HY-172609	SL-176		99.91%	Unkown
HY-N3027	Soyasaponin Aa	Inhibitor	99.88%	Unkown
HY-N7661	4β-Hydroxywithanolide E	Inhibitor	98%	Unkown
HY-P11642A	Sialorphin TFA		/	Unkown
HY-111370	mTOR inhibitor-2	Inhibitor	/	Unkown
HY-10237S	Boceprevir-d9	Inhibitor	/	Unkown
HY-10062	AZD3409	Inhibitor	/	Unkown
HY-10466BS	Daclatasvir-d6 hydrochloride		/	Unkown
HY-10466S	Daclatasvir-d6	Inhibitor	99.64%	Unkown
HY-10466S2	Daclatasvir-d16	Inhibitor	/	Unkown
HY-115869	RMC-4529	Inhibitor	/	Unkown
HY-119831	Rohitukine		/	Unkown
HY-121033	BS148		/	Unkown
HY-122670	VS-II-173		/	Unkown
HY-126956	Porphyra 334		/	Unkown
HY-130723	AMPK activator 2	Activator	/	Unkown
HY-149292	SR-4133	Inhibitor	/	Unkown
HY-157482	EBP-59	Inhibitor	/	Unkown
HY-157828	DSP-0390	Inhibitor	/	Unkown
HY-169751	Dihydro-N-caffeoyltyramine	Inhibitor	/	Unkown
HY-176948	M-1111	Inhibitor	/	Unkown
HY-181650	T133		/	Unkown
HY-181925	FD2024		/	Unkown
HY-182957	MNK/PIM-IN-2		/	Unkown
HY-B0660S1	Eicosapentaenoic acid 1,2,3,4,5-13C5	Activator	/	Unkown
HY-B0660S2	Eicosapentaenoic acid-d10		/	Unkown
HY-N11507	Tibesaikosaponin V	Inhibitor	/	Unkown
HY-N15121	4-O-Methyl-ascochlorin		/	Unkown
HY-N3027R	Soyasaponin Aa (Standard)	Inhibitor	/	Unkown
HY-N4103R	Fucosterol (Standard)	Inhibitor	/	Unkown
HY-P10323	T7 Peptide		/	Unkown
HY-P11642	Sialorphin		/	Unkown
HY-P6183	LXJ-02	Inducer	/	Unkown
HY-RS04130	EBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04278	EIF4EBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04279	EIF4EBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05464	GLB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12834	SH3D19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10466S1	Daclatasvir-13C2,d6	Inhibitor	/	Unkown
HY-116572	TASIN-1 hydrochloride		/	Unkown
HY-B0660A	Eicosapentaenoic acid metformin	Activator	/	Unkown
HY-N10612	Petasin		/	Unkown
HY-N1677R	2,6-Dimethoxy-1,4-benzoquinone (Standard)		/	Unkown
HY-RS18892	Ebp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20227	Eif4ebp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20664	Eif4ebp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25383	Ebp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26734	Eif4ebp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27175	Eif4ebp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EBP	RGD	RGD:620957
Mus musculus	EBP	MGD	MGI:107822
Bos taurus	EBP	VGNC	VGNC:54880
Others	EBP	NCBI