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SERP1 - stress associated endoplasmic reticulum protein 1 Gene

Also Known as RAMP4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27230

About SERP1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:150,541,998-150,546,496 (from NCBI)

This gene has 8 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 68.2), prostate (RPKM 46.3) and 25 other tissues.

Summary

Predicted to be involved in endoplasmic reticulum unfolded protein response and protein glycosylation. Predicted to act upstream of or within several processes, including multicellular organism aging; positive regulation of organ growth; and positive regulation of peptide hormone secretion. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]

SERP1 Products (1)

mRNA	Protein	Name
NM_014445.4	NP_055260.1	stress-associated endoplasmic reticulum protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	23264731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERP1 Protein Structure

RAMP4

0
66 a.a.

Protein Preferred Names	Protein Names
stress-associated endoplasmic reticulum protein 1	ribosome associated membrane protein 4

SERP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SERP1	Q9Y6X1	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	TNFRSF9	Homo sapiens	Q07011	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	TNFRSF9	Homo sapiens	Q07011	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	PLPPR1	Homo sapiens	Q8TBJ4	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	AQP8	Homo sapiens	O94778	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	AQP8	Homo sapiens	O94778	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	ALG3	Homo sapiens	Q92685	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	ALG3	Homo sapiens	Q92685	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	GJB3	Homo sapiens	O75712	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	GJB3	Homo sapiens	O75712	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	GKN1	Homo sapiens	Q9NS71	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	GKN1	Homo sapiens	Q9NS71	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	FRMD3	Homo sapiens	A2A2Y4	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	FRMD3	Homo sapiens	A2A2Y4	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	KCNF1	Homo sapiens	Q9H3M0	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	KCNF1	Homo sapiens	Q9H3M0	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SERP1	Q9Y6X1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	SERP1	Q9Y6X1	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arachnoiditis	Spinal Arachnoiditis Adhesive Arachnoiditis Chronic Arachnoiditis Familial Spinal Arachnoiditis Arachnitis Arachnoid Inflammation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12694	SERP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12727	SERPING1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18444	Serping1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24926	Serping1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SERP1	VGNC	VGNC:34464
Felis catus	SERP1	VGNC	VGNC:102840
Macaca mulatta	SERP1	VGNC	VGNC:77175
Rattus norvegicus	SERP1	RGD	RGD:620790
Mus musculus	SERP1	MGD	MGI:92638
Others	SERP1	NCBI