GPR37L1 - G protein-coupled receptor 37 like 1 Gene

Also Known as ETBRLP2; ETBR-LP-2; ET(B)R-LP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9283

About GPR37L1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,122,917-202,133,592 (from NCBI)

This gene has 7 transcripts (splice variants), 264 orthologues and 15 paralogues. Biased expression in brain (RPKM 18.1) and colon (RPKM 0.5).

Summary

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR37L1 Products (1)

mRNA Protein Name
NM_004767.5 NP_004758.3 G-protein coupled receptor 37-like 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
23690594 GOA
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
27072655 GOA
enables peptide binding IPI
IPI: Inferred from physical interaction
23690594 GOA
NOT enables prosaposin receptor activity IDA
IDA: Inferred from direct assay
27072655 GOA
enables prosaposin receptor activity IDA
IDA: Inferred from direct assay
23690594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20517885 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
23690594 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
23690594 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28688853 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR37L1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (147 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 37-like 1

  • endothelin B receptor-like protein 2

GPR37L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra
GPR37L1 O60883 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
GPR37L1 O60883 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
GPR37L1 O60883 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Validated Y2H
32296183
Intra
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 SYNPR Homo sapiens Q8TBG9
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
GPR37L1 O60883 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
GPR37L1 O60883 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
GPR37L1 O60883 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
GPR37L1 O60883 CLDND2 Homo sapiens Q8NHS1
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
Intra
GPR37L1 O60883 SCARF1 Homo sapiens Q14162
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM97 Homo sapiens Q5BJF2
Validated Y2H
32296183
Intra
GPR37L1 O60883 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
GPR37L1 O60883 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
GPR37L1 O60883 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra
GPR37L1 O60883 UPK1B Homo sapiens O75841
Validated Y2H
32296183
Intra
GPR37L1 O60883 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Validated Y2H
32296183
Intra
GPR37L1 O60883 CD46 Homo sapiens P15529-3
Y2H Array
32296183
Intra
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
GPR37L1 O60883 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
GPR37L1 O60883 SCARB2 Homo sapiens Q14108
Validated Y2H
32296183
Intra
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Validated Y2H
32296183
Intra
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Y2H Array
32296183
Intra
GPR37L1 O60883 CLEC2A Homo sapiens Q6UVW9
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
GPR37L1 O60883 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
GPR37L1 O60883 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
GPR37L1 O60883 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Validated Y2H
32296183
Intra
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Y2H Array
32296183
Intra
GPR37L1 O60883 RNF122 Homo sapiens Q9H9V4
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Validated Y2H
32296183
Intra
GPR37L1 O60883 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
GPR37L1 O60883 PRCP Homo sapiens P42785
Protease Assay
20517885
Intra
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
GPR37L1 O60883 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
GPR37L1 O60883 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
GPR37L1 O60883 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
GPR37L1 O60883 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra
GPR37L1 O60883 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra
GPR37L1 O60883 PLN Homo sapiens P26678
Validated Y2H
32296183
Intra
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
GPR37L1 O60883 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
GPR37L1 O60883 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
GPR37L1 O60883 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra
GPR37L1 O60883 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
GPR37L1 O60883 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
GPR37L1 O60883 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra
GPR37L1 O60883 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
GPR37L1 O60883 TM4SF4 Homo sapiens P48230
Validated Y2H
32296183
Intra
GPR37L1 O60883 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 6

  • ETL6

  • Familial Temporal Lobe Epilepsy 6
Megalencephalic Leukoencephalopathy With Subcortical Cysts

  • Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

  • Mlc

  • Van Der Knaap Disease

  • Lvm

  • Leukoencephalopathy With Swelling And Cysts

  • Megalencephaly-Cystic Leukodystrophy

  • Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome

  • Infantile Leukoencephalopathy And Megalencephaly

  • Leukoencephalopathy With Swelling And A Discrepantly Mild Course

  • Vacuolating Leukoencephalopathy

  • Megalencephalic Leukodystrophy

  • Megalencephaly-Cystic Leukodystrophy Syndrome

  • Van Der Knaap Syndrome

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1342 Prosaptide Tx14(A) 99.73% Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1342A Prosaptide Tx14(A) TFA Activator 99.81% Unkown
HY-RS05710 GPR37L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR37L1 VGNC VGNC:62691
Canis familiaris GPR37L1 VGNC VGNC:41433
Macaca mulatta GPR37L1 VGNC VGNC:72943
Mus musculus GPR37L1 MGD MGI:1928503
Bos taurus GPR37L1 VGNC VGNC:29586
Rattus norvegicus GPR37L1 RGD RGD:628835
Others GPR37L1 NCBI