CYB561A3 - cytochrome b561 family member A3 Gene
Also Known as LCYTB; CYBASC3
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 220002
Summary
Predicted to enable transmembrane ascorbate ferrireductase activity. Predicted to be involved in intracellular iron ion homeostasis. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jun 2026]
Broad expression in adrenal (RPKM 44.3), lymph node (RPKM 18.0) and 23 other tissues.
CYB561A3 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001161452.2 | NP_001154924.1 | lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2 |
| NM_001161454.1 | NP_001154926.1 | lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1 |
| NM_001300763.2 | NP_001287692.1 | lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3 |
| NM_153611.6 | NP_705839.3 | lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2 |
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CYB561A3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Referencias |
|---|---|---|---|---|---|---|---|
|
Intra
|
CYB561A3 | Q8NBI2 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | TM4SF18 | Homo sapiens | Q96CE8 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR101 | Homo sapiens | Q96P66 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR101 | Homo sapiens | Q96P66 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR101 | Homo sapiens | Q96P66 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | SHISAL1 | Homo sapiens | Q3SXP7 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | SHISAL1 | Homo sapiens | Q3SXP7 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | HERPUD2 | Homo sapiens | Q9BSE4 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | HERPUD2 | Homo sapiens | Q9BSE4 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | HERPUD2 | Homo sapiens | Q9BSE4 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR37L1 | Homo sapiens | O60883 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | GPR37L1 | Homo sapiens | O60883 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | LAPTM4B | Homo sapiens | Q86VI4 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | LAPTM4B | Homo sapiens | Q86VI4 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 25416956 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 25416956 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | RNF5 | Homo sapiens | Q99942 | 25416956 | |
|
Intra
|
CYB561A3 | Q8NBI2 | PVR | Homo sapiens | P15151 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | PVR | Homo sapiens | P15151 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CD40 | Homo sapiens | P25942 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CD40 | Homo sapiens | P25942 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | AGPAT5 | Homo sapiens | Q9NUQ2 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CREB3L3 | Homo sapiens | Q68CJ9 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | CREB3L3 | Homo sapiens | Q68CJ9 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | KLRC1 | Homo sapiens | P26715 | 32296183 | |
|
Intra
|
CYB561A3 | Q8NBI2 | KLRC1 | Homo sapiens | P26715 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction