CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

Also Known as CREBH; HYTG2; CREB-H; HYST1481

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84699

About CREB3L3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,153,631-4,173,054 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue.

Summary

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CREB3L3 Products (4)

mRNA Protein Name
NM_001271995.2 NP_001258924.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b
NM_001271996.2 NP_001258925.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c
NM_001271997.2 NP_001258926.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d
NM_032607.3 NP_115996.1 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11353085 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
11353085 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11353085 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16469704 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16469704 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
16469704 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16469704 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16469704 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11353085 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
16469704 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16236796 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16469704 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3L3 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (241 - 303)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 3

  • CREB/ATF family transcription factor

CREB3L3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CREB3L3 Q68CJ9 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 NFIL3 Homo sapiens Q16649
Peptide Array
20102225
Intra
CREB3L3 Q68CJ9 CREB3 Homo sapiens O43889
FRET
23661758
Intra
CREB3L3 Q68CJ9 CREB3L1 Homo sapiens Q96BA8
FRET
23661758
Intra
CREB3L3 Q68CJ9 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 DPY30 Homo sapiens Q9C005
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
CREB3L3 Q68CJ9 CREB3L3 Homo sapiens Q68CJ9
FRET
23661758
Intra
CREB3L3 Q68CJ9 CREB3L3 Homo sapiens Q68CJ9
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertriglyceridemia 2

  • HYTG2
Hypertriglyceridemia 1

  • Hypertriglyceridemia

  • Hypertriglyceridemia, Familial

  • Hypertriglyceridemia, Susceptibility To

  • HYTG1

  • FHTR

  • Hypertriglyceridemias Familial
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

  • PLSD-T

  • PLSDT

  • Platyspondylic Dysplasia, Torrance Type

  • Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

  • Thanatophoric Dysplasia, Torrance Variant

  • Platyspondylic Skeletal Dysplasia, Torrance Type

  • Torrance Type Platyspondylic Dysplasia

  • Platyspondylic Dysplasia, Torrance-Luton Type

  • Platyspondylic Lethal Skeletal Dysplasia Torrance Type

  • Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

  • Thanatophoric Dysplasia Torrance Variant

  • Platyspondylic Chondrodysplasia, Torrance-Luton Type

  • Plsd-Tl

  • Dysplasia, Skeletal, Platyspondylic, Torrance Type
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Osteogenesis Imperfecta, Type Xix

  • OI19

  • Osteogenesis Imperfecta Type 19

  • Osteogenesis Imperfecta Type Xix

  • Osteogenesis Imperfecta, Type 19

  • Osteogenesis Imperfecta 19
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03152 CREB3L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CREB3L3 RGD RGD:1308152
Macaca mulatta CREB3L3 VGNC VGNC:109609
Canis familiaris CREB3L3 VGNC VGNC:54593
Mus musculus CREB3L3 MGD MGI:2384786
Bos taurus CREB3L3 VGNC VGNC:27696
Felis catus CREB3L3 VGNC VGNC:61168
Others CREB3L3 NCBI