1. Gene
  2. NFIL3 - nuclear factor, interleukin 3 regulated Gene

NFIL3 - nuclear factor, interleukin 3 regulated Gene

Homo sapiens

Also known as E4BP4; IL3BP1; NFIL3A; NF-IL3A

Gene ID: 4783 | Gene type: protein coding

About NFIL3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:91,409,045-91,483,497 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 59.6), adrenal (RPKM 37.4) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

NFIL3 Products(3)

mRNA Protein Name
NM_001289999.2 NP_001276928.1 nuclear factor interleukin-3-regulated protein
NM_001290000.2 NP_001276929.1 nuclear factor interleukin-3-regulated protein
NM_005384.3 NP_005375.2 nuclear factor interleukin-3-regulated protein

NFIL3 Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (72 - 123)

Vert_IL3-reg_TF

Vert_IL3-reg_TF: Vertebrate interleukin-3 regulated transcription factor (130 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

nuclear factor interleukin-3-regulated protein

E4 promoter-binding protein 4

Related Diseases

Diseases Alias
Zebrafish Allergy

Danio Rerio Allergy

Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus NFIL3 MGD MGI:109495
Bos taurus NFIL3 VGNC VGNC:32041
Rattus norvegicus NFIL3 RGD RGD:620972
Felis catus NFIL3 VGNC VGNC:68478
Canis familiaris NFIL3 VGNC VGNC:43778
Macaca mulatta NFIL3 VGNC VGNC:75337