NFIL3 - nuclear factor, interleukin 3 regulated Gene

Also Known as E4BP4; IL3BP1; NFIL3A; NF-IL3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4783

About NFIL3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:91,409,045-91,483,497 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 59.6), adrenal (RPKM 37.4) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

NFIL3 Products (3)

mRNA Protein Name
NM_001289999.2 NP_001276928.1 nuclear factor interleukin-3-regulated protein
NM_001290000.2 NP_001276929.1 nuclear factor interleukin-3-regulated protein
NM_005384.3 NP_005375.2 nuclear factor interleukin-3-regulated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
1620116 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1620116 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20093779 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1620116 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20093779 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFIL3 Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (72 - 123)

Vert_IL3-reg_TF

Vert_IL3-reg_TF: Vertebrate interleukin-3 regulated transcription factor (130 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

nuclear factor interleukin-3-regulated protein

  • E4 promoter-binding protein 4

NFIL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NFIL3 Q16649 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra
NFIL3 Q16649 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra
NFIL3 Q16649 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
NFIL3 Q16649 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra
NFIL3 Q16649 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
Intra
NFIL3 Q16649 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
Intra
NFIL3 Q16649 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
NFIL3 Q16649 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
NFIL3 Q16649 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
NFIL3 Q16649 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
NFIL3 Q16649 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
NFIL3 Q16649 ATF1 Homo sapiens P18846
Peptide Array
20102225
Intra
NFIL3 Q16649 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
NFIL3 Q16649 NFIL3 Homo sapiens Q16649
Peptide Array
20102225
Intra
NFIL3 Q16649 NFIL3 Homo sapiens Q16649
FRET
23661758
Intra
NFIL3 Q16649 ATF1 Homo sapiens P18846
Anti Tag CoIP
28514442
Intra
NFIL3 Q16649 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
NFIL3 Q16649 CREB1 Homo sapiens P16220
Peptide Array
20102225
Intra
NFIL3 Q16649 NFIL3 Homo sapiens Q16649
Peptide Array
12805554
Intra
NFIL3 Q16649 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
NFIL3 Q16649 AMOTL2 Homo sapiens Q9Y2J4
Y2H
21516116
Intra
NFIL3 Q16649 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
NFIL3 Q16649 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
NFIL3 Q16649 MAFG Homo sapiens O15525
FRET
23661758
Intra
NFIL3 Q16649 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra
NFIL3 Q16649 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
32296183
Intra
NFIL3 Q16649 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
NFIL3 Q16649 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NFIL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811076 NFIL3 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Zebrafish Allergy

  • Danio Rerio Allergy
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09252 NFIL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18072 Nfil3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24547 Nfil3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NFIL3 MGD MGI:109495
Bos taurus NFIL3 VGNC VGNC:32041
Rattus norvegicus NFIL3 RGD RGD:620972
Felis catus NFIL3 VGNC VGNC:68478
Canis familiaris NFIL3 VGNC VGNC:43778
Macaca mulatta NFIL3 VGNC VGNC:75337
Others NFIL3 NCBI