AMOTL2 - angiomotin like 2 Gene

Also Known as LCCP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51421

About AMOTL2

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,355,345-134,375,417 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues.

Summary

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AMOTL2 Products (4)

mRNA Protein Name
NM_001278683.1 NP_001265612.1 angiomotin-like protein 2 isoform 1
NM_001278685.2 NP_001265614.1 angiomotin-like protein 2 isoform 3
NM_001363943.2 NP_001350872.1 angiomotin-like protein 2 isoform 4
NM_016201.4 NP_057285.3 angiomotin-like protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein localization IDA
IDA: Inferred from direct assay
23911299 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23911299 GOA
located in podosome IDA
IDA: Inferred from direct assay
23525008 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMOTL2 Protein Structure

Angiomotin_C

Angiomotin_C: Angiomotin C terminal (482 - 691)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

angiomotin-like protein 2

  • Leman coiled-coil protein

AMOTL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AMOTL2 Q9Y2J4 RAD51D Homo sapiens O75771
Y2H Array
31515488
Intra
AMOTL2 Q9Y2J4 SH3RF2 Homo sapiens Q8TEC5
Y2H Array
31515488
Intra
AMOTL2 Q9Y2J4 RNF20 Homo sapiens Q5VTR2
Y2H Array
31515488
Intra
AMOTL2 Q9Y2J4 PSMC3 Homo sapiens P17980
Anti Tag CoIP
24255178
Intra
AMOTL2 Q9Y2J4 GSTM5 Homo sapiens P46439
Y2H Array
31515488
Intra
AMOTL2 Q9Y2J4 NDC80 Homo sapiens O14777
Y2H Array
29892012
Intra
AMOTL2 Q9Y2J4 NDC80 Homo sapiens O14777
Y2H Array
31515488
Intra
AMOTL2 Q9Y2J4 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra
AMOTL2 Q9Y2J4 MAGOHB Homo sapiens Q96A72
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00665 AMOTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AMOTL2 VGNC VGNC:37837
Rattus norvegicus AMOTL2 RGD RGD:70977
Bos taurus AMOTL2 VGNC VGNC:25872
Felis catus AMOTL2 VGNC VGNC:59771
Mus musculus AMOTL2 MGD MGI:1929286
Others AMOTL2 NCBI