NDC80 - NDC80 kinetochore complex component Gene

Also Known as HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10403

About NDC80

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,571,557-2,616,635 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Broad expression in testis (RPKM 8.6), lymph node (RPKM 8.5) and 16 other tissues.

Summary

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with Other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

NDC80 Products (1)

mRNA Protein Name
NM_006101.3 NP_006092.1 kinetochore protein NDC80 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20360068 GOA
enables kinetochore adaptor activity IDA
IDA: Inferred from direct assay
30409912 GOA
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
18455984 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14699129 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
30409912 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
22581055 GOA
involved in attachment of spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
18455984 GOA
involved in attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
19468067 GOA
acts upstream of or within centrosome duplication IDA
IDA: Inferred from direct assay
18940925 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
14699129 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
19468067 GOA
acts upstream of or within metaphase chromosome alignment IDA
IDA: Inferred from direct assay
18940925 GOA
involved in metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
25743205 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
14699129 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
25743205 GOA
Cellular Component GO Annotation Evidence References Source
part of Ndc80 complex IDA
IDA: Inferred from direct assay
14699129 GOA
part of Ndc80 complex IPI
IPI: Inferred from physical interaction
18455984 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
14699129 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
18195732 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDC80 Protein Structure

Ndc80_HEC

Ndc80_HEC: HEC/Ndc80p family (50 - 207)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
Protein Preferred Names Protein Names

kinetochore protein NDC80 homolog

  • NDC80 homolog, kinetochore complex component

NDC80 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDC80 O14777 ZWINT Homo sapiens O95229
IF
16732327
Intra
NDC80 O14777 ZWINT Homo sapiens O95229
Y2H
16732327
Intra
NDC80 O14777 ZWINT Homo sapiens O95229
Pull Down
16732327
Intra
NDC80 O14777 ZWINT Homo sapiens O95229
Anti Bait CoIP
16732327
Intra
NDC80 O14777 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
Intra
NDC80 O14777 CENPH Homo sapiens Q9H3R5
Y2H
15713649
Intra
NDC80 O14777 TP53BP2 Homo sapiens Q13625-3
Validated Y2H
25416956
Intra
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
NDC80 O14777 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Validated Y2H
32296183
Intra
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Array
32296183
Intra
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra
NDC80 O14777 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 SFR1 Homo sapiens Q86XK3
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 SFR1 Homo sapiens Q86XK3
Y2H Array
25416956
Intra
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
NDC80 O14777 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
NDC80 O14777 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
NDC80 O14777 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
Intra
NDC80 O14777 CAGE1 Homo sapiens Q8TC20-4
Validated Y2H
32296183
Intra
NDC80 O14777 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Validated Y2H
32296183
Intra
NDC80 O14777 EPS15L1 Homo sapiens Q9UBC2-3
Y2H Array
32296183
Intra
NDC80 O14777 HIP1R Homo sapiens O75146-2
Validated Y2H
32296183
Intra
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
NDC80 O14777 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
NDC80 O14777 KLC3 Homo sapiens Q6P597
Y2H Array
25416956
Intra
NDC80 O14777 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 HAUS1 Homo sapiens Q96CS2
Y2H Array
25416956
Intra
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
32296183
Intra
NDC80 O14777 ATP6V1D Homo sapiens Q9Y5K8
Y2H Array
32296183
Intra
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
NDC80 O14777 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Y2H Array
32296183
Intra
NDC80 O14777 FAM9C Homo sapiens Q8IZT9
Validated Y2H
32296183
Intra
NDC80 O14777 KRT75 Homo sapiens O95678
Validated Y2H
32296183
Intra
NDC80 O14777 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
NDC80 O14777 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
NDC80 O14777 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Validated Y2H
32296183
Intra
NDC80 O14777 TNIP1 Homo sapiens Q15025
Y2H Array
25416956
Intra
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Array
30886144
Intra
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Array
31515488
Intra
NDC80 O14777 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 MED4 Homo sapiens Q9NPJ6
Validated Y2H
25416956
Intra
NDC80 O14777 ATF4 Homo sapiens P18848
Validated Y2H
32296183
Intra
NDC80 O14777 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
NDC80 O14777 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
NDC80 O14777 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
NDC80 O14777 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25416956
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
Intra
NDC80 O14777 STX11 Homo sapiens O75558
Y2H Array
25416956
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Anti Tag CoIP
25416956
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
GMS
17129783
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
GMS
15961401
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Anti Bait CoIP
14699129
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
TAP
24981860
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Pull Down
15961401
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
Density Sedimentation
15961401
Intra
NDC80 O14777 NUF2 Homo sapiens Q9BZD4
TAP
20360068
Intra
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Y2H Prey Pooling
32296183
Intra
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Validated Y2H
32296183
Intra
NDC80 O14777 THOC7 Homo sapiens Q6I9Y2
Y2H Array
32296183
Intra
NDC80 O14777 CCNK Homo sapiens O75909
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 CCNK Homo sapiens O75909
Y2H Array
25416956
Intra
NDC80 O14777 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
NDC80 O14777 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
Intra
NDC80 O14777 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
NDC80 O14777 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 HGS Homo sapiens O14964
Validated Y2H
32296183
Intra
NDC80 O14777 KRT6B Homo sapiens P04259
Validated Y2H
25416956
Intra
NDC80 O14777 KRT6B Homo sapiens P04259
Y2H Array
25416956
Intra
NDC80 O14777 CCNH Homo sapiens P51946
Validated Y2H
25416956
Intra
NDC80 O14777 CCNH Homo sapiens P51946
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 CCNH Homo sapiens P51946
Y2H Array
25416956
Intra
NDC80 O14777 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
NDC80 O14777 SGF29 Homo sapiens Q96ES7
Validated Y2H
25416956
Intra
NDC80 O14777 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
Intra
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Y2H Array
25416956
Intra
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
Intra
NDC80 O14777 IFT20 Homo sapiens Q8IY31
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 AMOTL2 Homo sapiens Q9Y2J4
Y2H Pooling
16189514
Intra
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Anti Tag CoIP
33961781
Intra
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Pooling
16189514
Intra
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
25416956
Intra
NDC80 O14777 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
Intra
NDC80 O14777 NDEL1 Homo sapiens Q9GZM8
Y2H Array
25416956
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
GMS
15961401
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
TAP
20360068
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Anti Tag CoIP
14699129
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
MAPPIT
25416956
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Density Sedimentation
15961401
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
Anti Bait CoIP
14699129
Intra
NDC80 O14777 SPC25 Homo sapiens Q9HBM1
TAP
24981860
Cross: Cross-species interaction Intra: Intraspecies interaction

NDC80 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83594 HEC1/HEC Antibody (YA3339) WB, IP Human, Mouse, Rat
HY-P83809 HEC1/HEC Antibody (YA3506) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P83809A HEC1/HEC Antibody (YA3506)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Endometrial Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Endometrium

  • Adenosquamous Carcinoma Of The Endometrium

  • Endometrial Adenosquamous Cancer

  • Endometrial Adenosquamous Cell Carcinoma
Endometrial Adenocarcinoma

  • Endometrial Endometrioid Adenocarcinoma

  • Endometrial Adenoacanthoma

  • Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

  • Adenocarcinoma Of Endometrium

  • Adenocarcinoma Of The Endometrium

  • Adenocarcinoma Of Uterus

  • Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

  • Endometrioid Adenoma Or Carcinoma

  • Endometrioid Adenomas And Carcinomas

  • Endometrioid Carcinoma Of Endometrium

  • Endometrium Adenocarcinoma
Intellectual Developmental Disorder, Autosomal Dominant 1

  • MRD1

  • Autosomal Dominant Non-Syndromic Intellectual Disability 1

  • Mental Retardation, Autosomal Dominant 1

  • Autosomal Dominant Intellectual Developmental Disorder 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09105 NDC80 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19722 Ndc80 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26218 Ndc80 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NDC80 MGD MGI:1914302
Canis familiaris NDC80 VGNC VGNC:43670
Rattus norvegicus NDC80 RGD RGD:1310154
Bos taurus NDC80 VGNC VGNC:31931
Felis catus NDC80 VGNC VGNC:63747
Macaca mulatta NDC80 VGNC VGNC:74975
Others NDC80 NCBI