CCNK - cyclin K Gene

Also Known as CPR4; IDDHDF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8812

About CCNK

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,481,409-99,512,440 (from NCBI)

This gene has 9 transcripts (splice variants), 169 orthologues, 6 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 33.7), testis (RPKM 31.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

CCNK Products (1)

mRNA	Protein	Name
NM_001099402.2	NP_001092872.1	cyclin-K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	9632813	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9632813	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22012619	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	22012619	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	21555514	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	22988298	GOA
involved in regulation of signal transduction	IDA IDA: Inferred from direct assay	26748711	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22988298	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin K-CDK12 complex	IPI IPI: Inferred from physical interaction	22012619	GOA
part of cyclin K-CDK13 complex	IPI IPI: Inferred from physical interaction	22012619	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNK Protein Structure

Cyclin_N

0
100
200
300
400
500
580 a.a.

Protein Preferred Names	Protein Names
cyclin-K

CCNK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCNK	O75909	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	CCNK	O75909	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	CCNK	O75909	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Y2H Pooling	16189514
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	CCNK	O75909	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	CCNK	O75909	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	CCNK	O75909	CDK13	Homo sapiens	Q14004	GMS	26748711
Intra	CCNK	O75909	CDK13	Homo sapiens	Q14004	X-Ray Diffraction	26748711

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Hypertelorism And Distinctive Facies	IDDHDF
Ccnk-Related Neurodevelopmental Disorder-Severe Intellectual Disability-Facial Dysmorphism Syndrome
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder	CHDFIDD Cdk13-Related Disorder Cdk13-Related Chdfidd Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Developmental And Epileptic Encephalopathy 66	DEE66 Epileptic Encephalopathy, Early Infantile, 66 Eiee66 Developmental And Epileptic Encephalopathy, 66 Early Infantile Epileptic Encephalopathy 66 Encephalopathy, Epileptic, Early Infantile, Type 66
Corneal Endothelial Dystrophy	Congenital Hereditary Endothelial Dystrophy Of Cornea Chandler Syndrome CHED Chandler'S Syndrome Endothelial Corneal Dystrophy Ched2 Maumenee Corneal Dystrophy Corneal Dystrophy, Congenital Hereditary Endothelial Dystrophy Of Corneal Endothelium Corneal Endothelial Dystrophy 2 Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly Ched2, Formerly Corneal Endothelial Dystrophy, Autosomal Recessive Endothelial Dystrophy Posterior Membrane Corneal Dystrophy Corneal Endothelial Dystrophy Type 2 Congenital Hereditary Endothelial Dystrophy Of The Cornea Congenital Hereditary Endothelial Dystrophy Type Ii Autosomal Recessive Ched Autosomal Recessive Congenital Hereditary Endothelial Dystrophy Chedii Congenital Hereditary Endothelial Dystrophy Type 2 Infantile Hereditary Endothelial Dystrophy Congenital Hereditary Endothelial Corneal Dystrophy Corneal Endothelial Dystrophy 2, Autosomal Recessive Iridocorneal Endothelial Syndrome Dystrophy, Corneal, Endothelial Corneal Endothelial Dystrophy 1, Autosomal Dominant
Intellectual Developmental Disorder, Autosomal Dominant 13	MRD13 Mental Retardation, Autosomal Dominant 13 Mental Retardation, Autosomal Dominant 13, With Neuronal Migration Defects Autosomal Dominant Non-Syndromic Intellectual Disability 13 Autosomal Dominant Intellectual Developmental Disorder 13 Autosomal Dominant Mental Retardation 13 Mental Retardation, Autosomal Dominant, Type 13
Hypertelorism	Eyes Wide Apart Eyes Widely Set Hypertelorism Of Orbit Ocular Hypertelorism Orbital Separation Excessive
Fanconi Anemia, Complementation Group F	Fanconi Anemia Complementation Group F FANCF

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168555	YJ1206		97.26%	Unkown
HY-W181530	NCT02		98.14%	Unkown
HY-148523	HQ005	Degrader	98.56%	Unkown
HY-179289	ZLY025		99.40%	Unkown
HY-RS02135	CCNK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18467	Ccnk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24948	Ccnk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCNK	MGD	MGI:1276106
Rattus norvegicus	CCNK	RGD	RGD:1595690
Macaca mulatta	CCNK	VGNC	VGNC:70734
Bos taurus	CCNK	VGNC	VGNC:26974
Felis catus	CCNK	VGNC	VGNC:60565
Canis familiaris	CCNK	VGNC	VGNC:38904
Others	CCNK	NCBI