CDK13 - cyclin dependent kinase 13 Gene

Also Known as CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8621

About CDK13

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:39,950,256-40,099,580 (from NCBI)

This gene has 23 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

CDK13 Products (5)

mRNA	Protein	Name
NM_003718.5	NP_003709.3	cyclin-dependent kinase 13 isoform 1
XM_017012751.3	XP_016868240.1	cyclin-dependent kinase 13 isoform X2
XM_011515597.4	XP_011513899.1	cyclin-dependent kinase 13 isoform X3
NM_031267.3	NP_112557.2	cyclin-dependent kinase 13 isoform 2
XM_017012750.3	XP_016868239.1	cyclin-dependent kinase 13 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	20952539	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	22012619	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16721827	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	1731328	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20952539	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	26748711	GOA
involved in regulation of signal transduction	IDA IDA: Inferred from direct assay	26748711	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin K-CDK13 complex	IPI IPI: Inferred from physical interaction	22012619	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	16721827	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK13 Protein Structure

Pkinase

0
300
600
900
1200
1512 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 13	CDC2-related protein kinase 5 cell division cycle 2-like protein kinase 5 cell division protein kinase 13 cholinesterase-related cell division controller

CDK13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK13	Q14004	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	CDK13	Q14004	CCNK	Homo sapiens	O75909	Pull Down	32707033
Intra	CDK13	Q14004	CCNK	Homo sapiens	O75909	Anti Tag CoIP	35271311
Intra	CDK13	Q14004	CCNK	Homo sapiens	O75909	Protein Kinase Assay	26748711
Intra	CDK13	Q14004	CCNK	Homo sapiens	O75909	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 62	RP62 Retinitis Pigmentosa, Type 62
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder	CHDFIDD Cdk13-Related Chdfidd Cdk13-Related Disorder Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
White-Sutton Syndrome	WHSUS Mrd37 Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome Mental Retardation, Autosomal Dominant 37 Autosomal Dominant Mental Retardation 37 Pogz-Related Intellectual Disability Syndrome
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Corneal Endothelial Dystrophy	Congenital Hereditary Endothelial Dystrophy Of Cornea Chandler Syndrome CHED Chandler'S Syndrome Endothelial Corneal Dystrophy Ched2 Maumenee Corneal Dystrophy Corneal Dystrophy, Congenital Hereditary Endothelial Dystrophy Of Corneal Endothelium Corneal Endothelial Dystrophy 2 Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly Ched2, Formerly Corneal Endothelial Dystrophy, Autosomal Recessive Endothelial Dystrophy Posterior Membrane Corneal Dystrophy Corneal Endothelial Dystrophy Type 2 Congenital Hereditary Endothelial Dystrophy Of The Cornea Congenital Hereditary Endothelial Dystrophy Type Ii Autosomal Recessive Ched Autosomal Recessive Congenital Hereditary Endothelial Dystrophy Chedii Congenital Hereditary Endothelial Dystrophy Type 2 Infantile Hereditary Endothelial Dystrophy Congenital Hereditary Endothelial Corneal Dystrophy Corneal Endothelial Dystrophy 2, Autosomal Recessive Iridocorneal Endothelial Syndrome Dystrophy, Corneal, Endothelial Corneal Endothelial Dystrophy 1, Autosomal Dominant
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-80013	THZ1	Inhibitor	99.84%	Unkown
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-130250	SR-4835	Inhibitor	99.73%	Unkown
HY-80013A	THZ1 Hydrochloride	Inhibitor	99.06%	Unkown
HY-168555	YJ1206	Degrader	97.26%	Unkown
HY-153244	MFH290	Inhibitor	98.29%	Unkown
HY-151110A	PROTAC CDK12/13 Degrader-1 TFA	Degrader	99.12%	Unkown
HY-168162	ZLC491	Degrader	98.51%	Unkown
HY-145072	BSJ-01-175	Inhibitor	99.88%	Unkown
HY-151110	PROTAC CDK12/13 Degrader-1	Degrader	98.01%	Unkown
HY-173059	CDK12/13-IN-3	Inhibitor	99.14%	Unkown
HY-168556	YJ9069	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-158170	CDK7-IN-28	Inhibitor	/	Unkown
HY-181035	DN1679	Degrader	/	Unkown
HY-173273	YJZ5118	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-48507	CDK12/13 ligand 4	Ligand	/	Unkown
HY-168658	CDK12/13 ligand 2	Degrader	/	Unkown
HY-181036	CDK12/13 ligand 3	Ligand	/	Unkown
HY-181405	SR-5037	Inhibitor	99.58%	Unkown
HY-181645	CDK12-IN-9	Inhibitor	/	Unkown
HY-168163	CDK12/13 ligand 1	Degrader	/	Unkown
HY-173042	CDK12/13-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK13	RGD	RGD:1311226
Canis familiaris	CDK13	VGNC	VGNC:39045
Mus musculus	CDK13	MGD	MGI:1916812
Bos taurus	CDK13	VGNC	VGNC:27118
Macaca mulatta	CDK13	VGNC	VGNC:70966
Felis catus	CDK13	VGNC	VGNC:60695
Others	CDK13	NCBI