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CDK12/13-IN-3

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CDK12/13-IN-3 (Compound 12b) is the orally active inhibitor for CDK that inhibits CDK12 and CDK13 with IC50 of 107.4 nM and 79.4 nM. CDK12/13-IN-3 inhibits the phosphorylation of Ser2 on the CTD of RNA polymerase II, induces DNA damage, and downregulates the gene expression of DNA damage response (DDR). CDK12/13-IN-3 exhibits antiproliferative activity against multiple cancer cells with IC50 of nanomolar levels. CDK12/13-IN-3 exhibits antitumor effect in mouse models, exhibits good pharmacokinetic properties with an oral bioavailability of 53.6%.

For research use only. We do not sell to patients.

  • Purity: 99.14%
  • CAS No.: 3029608-57-6
  • Formula: C19H22ClN7O2
  • Molecular Weight:415.88
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • CDK12/13-IN-3 Chemical Structure
    CDK12/13-IN-3 Chemical Structure
CAS No.: 3029608-57-6
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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100 mg

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  • CDK12/13-IN-3 Chemical Structure
    CDK12/13-IN-3 Chemical Structure
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  • CDK12/13-IN-3