CDK7-IN-28
CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication.
For research use only. We do not sell to patients.
- CAS No.: 3034082-58-8
- Formula: C23H27F3N6O
- Molecular Weight:460.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK7/Cyclin H/MNAT1 ＜5 nM (IC50) |
cdk2/cyclin A 6224 nM (IC50) |
CDK9/CyclinA 296 nM (IC50) |
CDK13/Cyclin K 152 nM (IC50) |
CDK7-IN-28 applies to MDA-MB-468 cells (IC50=2 nM), HepaRG cells (IC50 < 10 nM), NAl-H82 (IC50< 10 nM) has good antiproliferative activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:
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Concentration:
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Incubation Time:
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Result:
Chemical Information
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CAS No. 3034082-58-8
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Molecular Weight 460.50
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Formula C23H27F3N6O
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SMILES
FC(F)(C1=CN=C(N=C1C2=CNC3=C2CCCN(C3=O)C4CC4)N[C@@H]5CNC6(CC5)CC6)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK7-IN-28 Related Classifications
HY-158170 Related Classifications
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