CALCOCO1 - calcium binding and coiled-coil domain 1 Gene

Also Known as Cocoa; PP13275; calphoglin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57658

About CALCOCO1

This gene has 22 transcripts (splice variants), 256 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 52.1), lung (RPKM 44.3) and 25 other tissues.

Summary

Enables several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and nuclear receptor coactivator activity. Involved in positive regulation of gene expression and positive regulation of transcription, DNA-templated. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CALCOCO1 Products (2)

mRNA Protein Name
NM_001143682.2 NP_001137154.1 calcium-binding and coiled-coil domain-containing protein 1 isoform 2
NM_020898.3 NP_065949.1 calcium-binding and coiled-coil domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24245781 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
16344550 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
16344550 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16344550 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16344550 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
16344550 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
16344550 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16344550 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
16344550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCOCO1 Protein Structure

CALCOCO1

CALCOCO1: Calcium binding and coiled-coil domain (CALCOCO1) like (10 - 596)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
Protein Preferred Names Protein Names

calcium-binding and coiled-coil domain-containing protein 1

  • coiled-coil coactivator protein

CALCOCO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CALCOCO1 Q9P1Z2 TBC1D15 Homo sapiens Q8TC07
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 TBC1D15 Homo sapiens Q8TC07
Y2H Array
25416956
Intra
CALCOCO1 Q9P1Z2 TBC1D15 Homo sapiens Q8TC07
Y2H Prey Pooling
25416956
Intra
CALCOCO1 Q9P1Z2 ISOC1 Homo sapiens Q96CN7
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 ISOC1 Homo sapiens Q96CN7
Y2H Prey Pooling
25416956
Intra
CALCOCO1 Q9P1Z2 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra
CALCOCO1 Q9P1Z2 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 GABARAPL2 Homo sapiens P60520
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 CEP19 Homo sapiens Q96LK0
Y2H Prey Pooling
25416956
Intra
CALCOCO1 Q9P1Z2 DUSP13B Homo sapiens Q9UII6
Validated Y2H
25416956
Intra
CALCOCO1 Q9P1Z2 DUSP13B Homo sapiens Q9UII6
Validated Y2H
32296183
Intra
CALCOCO1 Q9P1Z2 DUSP13B Homo sapiens Q9UII6
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01830 CALCOCO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CALCOCO1 MGD MGI:1914738
Macaca mulatta CALCOCO1 VGNC VGNC:70668
Felis catus CALCOCO1 VGNC VGNC:60319
Rattus norvegicus CALCOCO1 RGD RGD:619812
Canis familiaris CALCOCO1 VGNC VGNC:38662
Bos taurus CALCOCO1 VGNC VGNC:26702
Others CALCOCO1 NCBI