DUSP13 - dual specificity phosphatase 13 Gene

Homo sapiens

Also known as BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B

Gene ID: 51207 | Gene type: protein coding

About DUSP13

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,094,434-75,109,191 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 30 paralogues. Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues.

Summary

Members of the protein-tyrosine Phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

DUSP13 Products(8)

mRNA	Protein	Name
NM_001007271.2	NP_001007272.1	dual specificity protein phosphatase 13 isoform 1
NM_001007272.2	NP_001007273.1	dual specificity protein phosphatase 13 isoform 2
NM_001007273.2	NP_001007274.1	dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320842.2	NP_001307771.1	dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320843.2	NP_001307772.1	dual specificity protein phosphatase 13 isoform 6
NM_001363514.2	NP_001350443.1	dual specificity protein phosphatase 13 isoform 9
NM_001412227.1	NP_001399156.1	dual specificity protein phosphatase 13 isoform 10
NM_016364.3	NP_057448.3	dual specificity protein phosphatase 13 isoform 6

DUSP13 Protein Structure

DSPc

0
100
188 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 13

Testis- and skeletal muscle-specific DUSP

Related Diseases

Diseases

Alias

Myoclonic Epilepsy Of Lafora

Lafora Disease	Epilepsy, Progressive Myoclonic 2b
EPM2	Melf
Epilepsy, Progressive Myoclonic 2a	Epm2a
Lafora'S Disease	Lafora Body Disease
Lbd	Epilepsy, Progressive Myoclonic, 2a
Lafora Progressive Myoclonic Epilepsy	Epilepsy Progressive Myoclonic 2
Lafora Body Disorder	Pme Type 2
Progressive Myoclonic Epilepsy Type 2	Progressive Myoclonus Epilepsy Type 2
Epilepsy, Progressive Myoclonic 2	Epm2b
Ld	Progressive Myoclonic Epilepsy 2
Progressive Myoclonic Epilepsy 2a	Progressive Myoclonic Epilepsy 2b
Progressive Myoclonic Epilepsy Lafora Type	Epilepsy, Myoclonic, Of Lafora

Juvenile Polyposis Syndrome

JPS	Juvenile Intestinal Polyposis
Jip	Pji
Juvenile Gastrointestinal Polyposis	Juvenile Polyposis
Polyposis, Juvenile Intestinal	Polyposis, Familial, Of Entire Gastrointestinal Tract
Polyposis Familial Of Entire Gastrointestinal Tract	Polyposis Juvenile Intestinal
Polyposis Syndrome, Juvenile

Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism	DYT3
Xdp	Lubag
Dystonia-Parkinsonism, X-Linked	Torsion Dystonia-Parkinsonism, Filipino Type
Dyt-Taf1	X-Linked Dystonia-Parkinsonism Syndrome
X-Linked Torsion Dystonia-Parkinsonism Syndrome	Dystonia Musculorum Deformans
X-Linked Dystonia-Parkinsonism/Lubag	Lubag Syndrome
Dystonia-3	Torsion Dystonia-Parkinsonism Filipino Type
X-Linked Torsion Dystonia 3	Dystonia, Torsion, X-Linked, Type 3

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04054	DUSP13 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP13	RGD	RGD:1359712
Mus musculus	DUSP13	MGD	MGI:1351599
Bos taurus	DUSP13	VGNC	VGNC:107306
Canis familiaris	DUSP13	VGNC	VGNC:106597

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