CARD9 - caspase recruitment domain family member 9 Gene

Also Known as CANDF2; IMD103; hCARD9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64170

About CARD9

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,363,956-136,373,669 (from NCBI)

This gene has 11 transcripts (splice variants), 188 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 5.8), spleen (RPKM 4.7) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the Caspase family, and thus plays an important regulatory role in cell Apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of Apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

CARD9 Products (2)

mRNA	Protein	Name
NM_052813.5	NP_434700.2	caspase recruitment domain-containing protein 9 isoform 1
NM_052814.4	NP_434701.1	caspase recruitment domain-containing protein 9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11053425	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22267217	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11053425	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	11053425	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antifungal innate immune response	IDA IDA: Inferred from direct assay	26488816	GOA
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	24231284	GOA
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	33548172	GOA
involved in immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	33548172	GOA
involved in neutrophil mediated immunity	IMP IMP: Inferred from mutant phenotype	26679537	GOA
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	26488816	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	25057046	GOA
involved in positive regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	24231284	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11053425	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	11053425	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	24231284	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	26961233	GOA
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	26961233	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25702837	GOA
acts upstream of or within positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	31296852	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	26488816	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11053425	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22267217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD9 Protein Structure

CARD

0
100
200
300
400
500
536 a.a.

Protein Preferred Names	Protein Names
caspase recruitment domain-containing protein 9

CARD9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CARD9	Q9H257	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	CARD9	Q9H257	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	CARD9	Q9H257	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	CARD9	Q9H257	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Array	25416956
Intra	CARD9	Q9H257	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	ZNF572	Homo sapiens	Q7Z3I7	Validated Y2H	25416956
Intra	CARD9	Q9H257	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	25416956
Intra	CARD9	Q9H257	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	CARD9	Q9H257	a8k932_human	Homo sapiens	A8K932	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	CARD9	Q9H257	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	CARD9	Q9H257	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	CARD9	Q9H257	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	CARD9	Q9H257	ZNF250	Homo sapiens	P15622-3	Validated Y2H	25416956
Intra	CARD9	Q9H257	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	CARD9	Q9H257	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	CARD9	Q9H257	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	CARD9	Q9H257	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	CARD9	Q9H257	RTP5	Homo sapiens	Q14D33	Y2H Array	25416956
Intra	CARD9	Q9H257	RTP5	Homo sapiens	Q14D33	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	VPS28	Homo sapiens	Q548N1	Validated Y2H	25416956
Intra	CARD9	Q9H257	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	USP15	Homo sapiens	Q9Y4E8	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	USP15	Homo sapiens	Q9Y4E8	Y2H Array	25416956
Intra	CARD9	Q9H257	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	CARD9	Q9H257	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	CARD9	Q9H257	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TSNAX	Homo sapiens	Q99598	Validated Y2H	25416956
Intra	CARD9	Q9H257	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	CARD9	Q9H257	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	CARD9	Q9H257	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TNFAIP1	Homo sapiens	Q13829	Y2H Array	25416956
Intra	CARD9	Q9H257	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	25416956
Intra	CARD9	Q9H257	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	CARD9	Q9H257	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	CARD9	Q9H257	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
Intra	CARD9	Q9H257	PBX2	Homo sapiens	P40425	Validated Y2H	25416956
Intra	CARD9	Q9H257	PBX2	Homo sapiens	P40425	Y2H Array	25416956
Intra	CARD9	Q9H257	EIF4E2	Homo sapiens	O60573	Validated Y2H	25416956
Intra	CARD9	Q9H257	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	CARD9	Q9H257	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Intra	CARD9	Q9H257	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	CARD9	Q9H257	ABLIM1	Homo sapiens	O14639	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	ABLIM1	Homo sapiens	O14639	Validated Y2H	25416956
Intra	CARD9	Q9H257	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	CARD9	Q9H257	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	CARD9	Q9H257	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	29892012
Intra	CARD9	Q9H257	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	25416956
Intra	CARD9	Q9H257	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	ZNF655	Homo sapiens	Q8N720	Validated Y2H	25416956
Intra	CARD9	Q9H257	ZNF655	Homo sapiens	Q8N720	Y2H Array	25416956
Intra	CARD9	Q9H257	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TRIM29	Homo sapiens	Q14134	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TRIM29	Homo sapiens	Q14134	Validated Y2H	25416956
Intra	CARD9	Q9H257	TRIM29	Homo sapiens	Q14134	Y2H Array	25416956
Intra	CARD9	Q9H257	PHC2	Homo sapiens	Q8IXK0	Validated Y2H	25416956
Intra	CARD9	Q9H257	STX11	Homo sapiens	O75558	Y2H Array	25416956
Intra	CARD9	Q9H257	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	CARD9	Q9H257	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	CARD9	Q9H257	LENG1	Homo sapiens	Q96BZ8	Y2H Array	25416956
Intra	CARD9	Q9H257	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	C2CD6	Homo sapiens	Q53TS8	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	C2CD6	Homo sapiens	Q53TS8	Validated Y2H	25416956
Intra	CARD9	Q9H257	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	CARD9	Q9H257	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	FAM124B	Homo sapiens	Q9H5Z6	Validated Y2H	25416956
Intra	CARD9	Q9H257	PAK5	Homo sapiens	Q9P286	Y2H Array	31515488
Intra	CARD9	Q9H257	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	KRT19	Homo sapiens	P08727	Y2H Array	25416956
Intra	CARD9	Q9H257	KRT19	Homo sapiens	P08727	Validated Y2H	25416956
Intra	CARD9	Q9H257	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	DUSP13B	Homo sapiens	Q9UII6	Validated Y2H	25416956
Intra	CARD9	Q9H257	DUSP13B	Homo sapiens	Q9UII6	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TCL1A	Homo sapiens	P56279	Y2H Array	25416956
Intra	CARD9	Q9H257	DAXX	Homo sapiens	Q9UER7	Validated Y2H	25416956
Intra	CARD9	Q9H257	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	CARD9	Q9H257	IHO1	Homo sapiens	Q8IYA8	Y2H Array	25416956
Intra	CARD9	Q9H257	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	CARD9	Q9H257	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	CARD9	Q9H257	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	CARD9	Q9H257	TCEANC	Homo sapiens	Q8N8B7	Y2H Prey Pooling	25416956
Intra	CARD9	Q9H257	TCEANC	Homo sapiens	Q8N8B7	Validated Y2H	25416956
Intra	CARD9	Q9H257	BCL10	Homo sapiens	O95999	MAPPIT	25416956
Intra	CARD9	Q9H257	BCL10	Homo sapiens	O95999	Anti Bait CoIP	22267217

Cross: Cross-species interaction Intra: Intraspecies interaction

CARD9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80582	CARD9 Antibody (YA566)	WB	Human
HY-P80582A	CARD9 Antibody (YA566)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Immunodeficiency 103 Fungal Infections	Predisposition To Invasive Fungal Disease Due To Card9 Deficiency Candidiasis, Familial, 2 CANDF2 Candidiasis, Familial Chronic Mucocutaneous, Autosomal Recessive Card9 Immunodeficiency Familial Chronic Mucocutaneous Candidiasis Invasive Candidiasis-Deep Dermatophytosis Syndrome IMD103 Immunodeficiency 103, Susceptibility To Fungal Infections Immunodeficiency 103, Susceptibility To Fungal Infection Immunodeficiency 103 Fungal Infection Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous Card9 Deficiency Familial Chronic Mucocutaneous Candidiasis Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous, Autosomal Recessive Candidiasis, Familial, Type 2
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Phaeohyphomycosis	Infection By Dematiacious Fungi Phaehyphomycosis Phaeomycosis Pheohyphomycosis Infection By Dematiacious Fungi [Phaehyphomycosis] Dematiaceous Fungal Infection
Endophthalmitis
Sporotrichosis	Rose Gardener'S Disease
Meningoencephalitis	Acquired Toxoplasmal Meningoencephalitis Meningoencephalitis Due To Acquired Toxoplasmosis Meningoencephalitis Due To Toxoplasmosis Toxoplasma Meningoencephalitis
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Tinea Profunda	Deep Seated Dermatophytosis Granuloma Trichophyticum Majocchi'S Granuloma
Tinea Corporis	Dermatophytosis Of The Body Dermatophytosis Of The Trunk
Cutaneous Candidiasis	Candidiasis, Cutaneous
Fungal Infectious Disease	Mycoses Mycosis
Tinea Cruris	Dermatophytosis Of Groin & Perianal Area Dermatophytosis Of Groin And Perianal Area Dhobie Itch Tinea Of Perianal Region
Subcutaneous Mycosis	Subcutaneous Fungal Disease
Tinea Barbae	Dermatophytosis Of Beard
Primary Systemic Mycosis
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Tinea Capitis	Dermatophytosis Of Scalp Scalp Ringworm Dermatophytosis Of Scalp Or Beard Tinea Capitis Due To Trichophyton Rubrum Trichophyton Rubrum Tinea Capitis
Tinea Pedis	Athlete'S Foot Dermatophytosis Of Foot Ringworm Of Foot Moccasin Foot
Vulvovaginal Candidiasis	Candidiasis Of Vulva And Vagina Candidiasis, Vulvovaginal Candidal Vulvovaginitis Candidal: Cervix Monilial Vulvovaginitis Candidiasis Vulvovaginal
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Tinea Unguium	Dermatophytosis Of Nail Onychomycosis Due To Dermatophyte Cellulitis And Abscess Cellulitis And Abscess Of Buttock Cellulitis And Abscess Of Face Cellulitis And Abscess Of Finger Cellulitis And Abscess Of Finger And Toe Cellulitis And Abscess Of Gluteal Region Cellulitis And Abscess Of Trunk Cellulitis And Abscess Of Upper Arm And Forearm Dermatophytic Onychia Dermatophytic Onychomycosis Onychomycosis Ringworm Of Nails Tinea Of Nail
Dermatomycosis	Dermatomycoses
Immunodeficiency 11b With Atopic Dermatitis	IMD11B Atopic Dermatitis, Elevated Ige, And Eosinophilia Immunodeficiency 11b
Tinea Manuum	Tinea Manus Dermatophytosis Of Hand
Superficial Mycosis	Piedra Steroid-Modified Tinea Infection
Tinea Imbricata	Kerion Celsi Trichophyton Infection Tinea Imbricata, Susceptibility To Susceptibility To Tinea Imbricata Tinea Capitis Profunda Trichophytia Profunda Barbae Trichophytia Profunda Capitis Tinea Capitis
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Trichosporonosis
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Penicilliosis
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
Invasive Aspergillosis	Aspergillosis Invasive
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Blastomycosis	Gilchrist'S Disease North American Blastomycosis Blastomyces Dermatitidis Infection Blastomycotic Infection Infection By Blastomyces Dermatitidis Gilchrist Disease Chicago Disease Chicago Disease Or Disorder Blastomycosis, Unspecified Blastomyces Infection
Coccidioidomycosis	Valley Fever Primary Extrapulmonary Coccidioidomycosis Coccidioides Immitis Infection Coccidiosis Coccidioides Infection Coccidioidomycosis, Unspecified San Joaquin Fever California Disease Desert Fever Desert Rheumatism San Joaquin Valley Fever Enteric Coccidiosis Primary Pulmonary Coccidioidomycosis Acute Coccidioidomycosis Posadas Wernicke Disease
Vaginal Disease	Vaginal Diseases
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Immunodeficiency 11	Immunodeficiency 11a Severe Combined Immunodeficiency Due To Card11 Deficiency IMD11A Imd11 Card11 Immunodeficiency Scid Due To Card11 Deficiency Card11 Deficiency Immunodeficiency 11 A
Immunodeficiency 29	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency IMD29 Il12b Deficiency Immunodeficiency 29, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency Msmd Due To Complete Il12b Deficiency Msmd Due To Complete Interleukin 12b Deficiency Immunodeficiency, Type 29, Mycobacteriosis
Esophageal Candidiasis	Candidiasis Of The Esophagus Candida Esophagitis Candidal Esophagitis Esophageal Moniliasis Esophageal Thrush
Mucormycosis	Zygomycosis Disseminated Mucormycosis Absidia Infection Absidia Mucoromycosis Cunninghamella Infection Cunninghamella Mucoromycosis Infection By Absidia Spp Infection By Rhizopus Spp Mucor Infection Mucor Mucoromycosis Infection By Mucor Spp Rhizopus Infection Rhizopus Mucoromycosis Infection By Cunninghamella Spp Phycomycosis Nos
Cryptococcosis	Cryptococcus Neoformans Infection Torulosis Busse-Buschke'S Disease Cryptococcal Infection European Cryptococcosis Torula Infection By Cryptococcus Neoformans Cryptococcosis Infection European Blastomycosis European Blastomycotic Infection European Blastomycoses Infection Torula Histolytica Infection
Adenoiditis	Chronic Adenoiditis
Eumycotic Mycetoma	Eumycetoma Maduromycosis Mycetoma Madura Foot Maduromycosis, Mycotic Mycotic Mycetoma Mycetoma Of Foot Eumycotic Maduromycosis Mycetoma Due To Fungal Infection
Fungal Meningitis	Meningitis, Fungal Mycotic Meningitis
Allergic Bronchopulmonary Aspergillosis	Aspergillosis, Allergic Bronchopulmonary Abpa Allergic Bronchopulmonary Mycosis Hinson-Pepys Disease Pulmonary Aspergillus Disease Allergic Aspergillosis Aspergillosis Allergic Bronchopulmonary
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Pneumocystosis	Pneumocystis Jirovecii Pneumonia Pneumocystis Carinii Pneumonia Pneumocystis Pneumonia Pulmonary Pneumocystosis PCP Pneumocystosis Pneumonia Pneumonia Pneumocystis Carinii Pneumonia, Pneumocystis Pneumocystis Jiroveci Pneumonia
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115497	BRD5529	Inhibitor	98.94%	Unkown
HY-RS01923	CARD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18055	Card9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24530	Card9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CARD9	VGNC	VGNC:38718
Rattus norvegicus	CARD9	RGD	RGD:708370
Macaca mulatta	CARD9	VGNC	VGNC:70567
Mus musculus	CARD9	MGD	MGI:2685628
Bos taurus	CARD9	VGNC	VGNC:26764
Others	CARD9	NCBI