PAK5 - p21 (RAC1) activated kinase 5 Gene

Also Known as PAK7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57144

About PAK5

Cytogenetic location: 20p12.2 Genomic coordinates (GRCh38): 20:9,537,370-9,839,076 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 35 paralogues. Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

PAK5 Products (7)

mRNA Protein Name
NM_020341.5 NP_065074.1 serine/threonine-protein kinase PAK 5
XM_017027960.2 XP_016883449.1 serine/threonine-protein kinase PAK 5 isoform X1
NM_177990.4 NP_817127.1 serine/threonine-protein kinase PAK 5
XM_017027965.2 XP_016883454.1 serine/threonine-protein kinase PAK 5 isoform X1
XM_017027962.2 XP_016883451.1 serine/threonine-protein kinase PAK 5 isoform X1
XM_017027961.2 XP_016883450.1 serine/threonine-protein kinase PAK 5 isoform X1
XM_017027964.2 XP_016883453.1 serine/threonine-protein kinase PAK 5 isoform X1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19060904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK5 Protein Structure

PBD

PBD: P21-Rho-binding domain (10 - 63)

Pkinase

Pkinase: Protein kinase domain (454 - 700)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 5

  • PAK-5

  • PAK-7

  • p21 (RAC1) activated kinase 7

  • p21 protein (Cdc42/Rac)-activated kinase 7

  • p21(CDKN1A)-activated kinase 7

  • p21-activated kinase 5

  • p21-activated kinase 7

  • p21CDKN1A-activated kinase 7

  • protein kinase PAK5

  • serine/threonine-protein kinase PAK 7

  • serine/threonine-protein kinase PAK7

PAK5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAK5 Q9P286 INKA1 Homo sapiens Q96EL1
Validated Y2H
25416956
Intra
PAK5 Q9P286 INKA1 Homo sapiens Q96EL1
Y2H Array
25416956
Intra
PAK5 Q9P286 INKA1 Homo sapiens Q96EL1
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
Intra
PAK5 Q9P286 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 CRBN Homo sapiens Q96SW2
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
PAK5 Q9P286 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
PAK5 Q9P286 UXT Homo sapiens Q9UBK9
Validated Y2H
25416956
Intra
PAK5 Q9P286 EXOSC1 Homo sapiens Q9Y3B2
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 EXOSC1 Homo sapiens Q9Y3B2
Y2H Array
25416956
Intra
PAK5 Q9P286 CCNG1 Homo sapiens P51959
Validated Y2H
25416956
Intra
PAK5 Q9P286 CCNG1 Homo sapiens P51959
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
PAK5 Q9P286 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
PAK5 Q9P286 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
PAK5 Q9P286 EMD Homo sapiens P50402
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
PAK5 Q9P286 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
PAK5 Q9P286 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
PAK5 Q9P286 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PAK5 Q9P286 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PAK5 Q9P286 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
PAK5 Q9P286 LENG1 Homo sapiens Q96BZ8
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 SORBS3 Homo sapiens O60504
Validated Y2H
25416956
Intra
PAK5 Q9P286 ARMC7 Homo sapiens Q9H6L4
Y2H Prey Pooling
25416956
Intra
PAK5 Q9P286 GCC1 Homo sapiens Q96CN9
Validated Y2H
25416956
Intra
PAK5 Q9P286 CARD9 Homo sapiens Q9H257
Y2H Array
31515488
Intra
PAK5 Q9P286 CARD9 Homo sapiens Q9H257
Validated Y2H
25416956
Intra
PAK5 Q9P286 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
Intra
PAK5 Q9P286 CDC42 Homo sapiens P60953
Pull Down
32707033
Intra
PAK5 Q9P286 CDC42 Homo sapiens P60953
Y2H Pooling
20936779
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK5 Proteins

Cat. No. Product Name Accession Purity
HY-P72065 PAK5 Protein, Human (sf9, His) Q8TB93 (M1-Q293, P27A) ≥ 85%, as determined by reducing SDS-PAGE.

PAK5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810992 PAK7 Antibody WB, IHC-P Human, Mouse, Rat
HY-P83588 Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333) WB Human, Mouse, Rat
HY-P83588A Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Large Cell Neuroendocrine Carcinoma
Trichorhinophalangeal Syndrome, Type I

  • Trichorhinophalangeal Dysplasia Type I

  • TRPS1

  • Trichorhinophalangeal Syndrome Type I

  • Trps I

  • Trichorhinophalangeal Syndrome Type 1

  • Type I Trichorhinophalangeal Syndrome

  • Giedion Syndrome

  • Trp Syndrome

  • Tricho-Rhino-Phalangeal Syndrome 1

  • Trichorhinophalangeal Syndrome, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1
HY-13007B PF-3758309 dihydrochloride Inhibitor / Phase 1
HY-13007A PF-3758309 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PAK5 VGNC VGNC:81138
Mus musculus PAK5 MGD MGI:1920334
Rattus norvegicus PAK5 RGD RGD:1312009
Macaca mulatta PAK5 VGNC VGNC:97111
Canis familiaris PAK5 VGNC VGNC:53544
Others PAK5 NCBI