INKA1 - inka box actin regulator 1 Gene

Also Known as C3orf54; FAM212A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389119

About INKA1

This gene has 1 transcript (splice variant), 263 orthologues and 1 paralogue. Broad expression in skin (RPKM 6.6), lung (RPKM 3.2) and 23 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. Predicted to act upstream of or within neural tube development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

INKA1 Products (2)

mRNA Protein Name
NM_001366281.1 NP_001353210.1 PAK4-inhibitor INKA1 isoform 2
NM_203370.2 NP_976248.2 PAK4-inhibitor INKA1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
26607847 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
26607847 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26607847 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26607847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INKA1 Protein Structure

FAM212

FAM212: FAM212 family (151 - 206)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

PAK4-inhibitor INKA1

  • HInca

INKA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INKA1 Q96EL1 BSCL2 Homo sapiens J3KQ12
Y2H Array
32814053
Intra
INKA1 Q96EL1 BSCL2 Homo sapiens J3KQ12
Validated Y2H
32814053
Intra
INKA1 Q96EL1 BSCL2 Homo sapiens J3KQ12
Y2H Pooling
32814053
Intra
INKA1 Q96EL1 PEX7 Homo sapiens O00628-2
Y2H Array
32814053
Intra
INKA1 Q96EL1 PEX7 Homo sapiens O00628-2
Validated Y2H
32814053
Intra
INKA1 Q96EL1 PEX7 Homo sapiens O00628-2
Y2H Pooling
32814053
Intra
INKA1 Q96EL1 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
INKA1 Q96EL1 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
INKA1 Q96EL1 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
INKA1 Q96EL1 PAK4 Homo sapiens O96013
Anti Tag CoIP
33961781
Intra
INKA1 Q96EL1 PAK5 Homo sapiens Q9P286
MAPPIT
25416956
Intra
INKA1 Q96EL1 PAK5 Homo sapiens Q9P286
Y2H Array
31515488
Intra
INKA1 Q96EL1 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
INKA1 Q96EL1 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Visual Cortex Disease

  • Visual Cortex Dysfunction

  • Visual Cortex Disorder

  • Visual Cortical Disorder

  • Disease Of Visual Cortex
Visual Pathway Disease

  • Disorder Of Visual Pathways
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06818 INKA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INKA1 VGNC VGNC:28790
Felis catus INKA1 VGNC VGNC:62925
Canis familiaris INKA1 VGNC VGNC:40659
Mus musculus INKA1 MGD MGI:1915426
Macaca mulatta INKA1 VGNC VGNC:73692
Rattus norvegicus INKA1 RGD RGD:1560778
Others INKA1 NCBI