PAK5 Protein, Human (sf9, His)

PAK5, a serine/threonine protein kinase, is a versatile player in various signaling pathways, influencing cytoskeleton regulation, cell migration, proliferation, and cell survival. Activation by diverse effectors, including growth factor receptors or active CDC42 and RAC1, induces a conformational change and subsequent autophosphorylation on multiple serine and/or threonine residues. PAK5's impact extends to the phosphorylation of the proto-oncogene RAF1, enhancing its kinase activity, and the promotion of cell survival through the phosphorylation of the BCL2 antagonist of cell death, BAD. Furthermore, PAK5 phosphorylates CTNND1, likely regulating cytoskeletal organization and cell morphology. It plays a role in microtubule stability by inhibiting MARK2 and simultaneously destabilizes the F-actin network, resulting in the disappearance of stress fibers and focal adhesions. PAK5 emerges as a key regulator at the intersection of diverse cellular processes.