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GCC1 - GRIP and coiled-coil domain containing 1 Gene

Also Known as GCC1P; GCC88

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79571

About GCC1

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,580,628-127,585,596 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.0), bone marrow (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

GCC1 Products (1)

mRNA	Protein	Name
NM_024523.6	NP_078799.2	GRIP and coiled-coil domain-containing protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCC1 Protein Structure

GRIP

0
200
400
600
775 a.a.

Protein Preferred Names	Protein Names
GRIP and coiled-coil domain-containing protein 1	golgi coiled-coil 1

GCC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GCC1	Q96CN9	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	GCC1	Q96CN9	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	GCC1	Q96CN9	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	GCC1	Q96CN9	ZNF276	Homo sapiens	Q8N554-2	Y2H Array	25416956
Intra	GCC1	Q96CN9	NAV1	Homo sapiens	Q8NEY1-4	Y2H Array	25416956
Intra	GCC1	Q96CN9	NAV1	Homo sapiens	Q8NEY1-4	Validated Y2H	25416956
Intra	GCC1	Q96CN9	NAV1	Homo sapiens	Q8NEY1-4	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	HDX	Homo sapiens	Q7Z353	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	HDX	Homo sapiens	Q7Z353	Y2H Array	32296183
Intra	GCC1	Q96CN9	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	GCC1	Q96CN9	ZFP90	Homo sapiens	Q8TF47	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	ZFP90	Homo sapiens	Q8TF47	Y2H Array	32296183
Intra	GCC1	Q96CN9	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	GCC1	Q96CN9	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	GCC1	Q96CN9	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	GCC1	Q96CN9	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	GCC1	Q96CN9	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	GCC1	Q96CN9	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Array	32296183
Intra	GCC1	Q96CN9	ICA1L	Homo sapiens	Q8NDH6-2	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	FAM83A	Homo sapiens	Q86UY5	Y2H Array	32296183
Intra	GCC1	Q96CN9	FAM83A	Homo sapiens	Q86UY5	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	GCC1	Q96CN9	KIAA0753	Homo sapiens	Q2KHM9	Validated Y2H	25416956
Intra	GCC1	Q96CN9	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	GCC1	Q96CN9	CEP57	Homo sapiens	Q86XR8	Y2H Array	25416956
Intra	GCC1	Q96CN9	CEP57	Homo sapiens	Q86XR8	Y2H	21516116
Intra	GCC1	Q96CN9	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	19060904
Intra	GCC1	Q96CN9	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	19060904
Intra	GCC1	Q96CN9	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
Intra	GCC1	Q96CN9	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
Intra	GCC1	Q96CN9	DNAJA3	Homo sapiens	Q96EY1-2	Y2H Array	25416956
Intra	GCC1	Q96CN9	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	GCC1	Q96CN9	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	ATF4	Homo sapiens	P18848	Y2H Array	25416956
Intra	GCC1	Q96CN9	BIRC2	Homo sapiens	Q13490	Y2H Array	32296183
Intra	GCC1	Q96CN9	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	XIAP	Homo sapiens	P98170	Y2H Array	32296183
Intra	GCC1	Q96CN9	PPP1R27	Homo sapiens	Q86WC6	Y2H Array	32296183
Intra	GCC1	Q96CN9	PPP1R27	Homo sapiens	Q86WC6	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	OIP5	Homo sapiens	O43482	Validated Y2H	25416956
Intra	GCC1	Q96CN9	OIP5	Homo sapiens	O43482	Y2H Array	25416956
Intra	GCC1	Q96CN9	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GCC1	Q96CN9	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GCC1	Q96CN9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	LCA5	Homo sapiens	Q86VQ0	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	LCA5	Homo sapiens	Q86VQ0	Y2H Array	32296183
Intra	GCC1	Q96CN9	TRIM29	Homo sapiens	Q14134	Pull Down	16189514
Intra	GCC1	Q96CN9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	GCC1	Q96CN9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	GCC1	Q96CN9	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	GCC1	Q96CN9	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	PAK5	Homo sapiens	Q9P286	Y2H Array	25416956
Intra	GCC1	Q96CN9	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	KATNAL1	Homo sapiens	Q9BW62	Validated Y2H	32296183
Intra	GCC1	Q96CN9	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	KATNAL1	Homo sapiens	Q9BW62	Y2H Array	32296183
Intra	GCC1	Q96CN9	ABI2	Homo sapiens	Q9NYB9	Y2H Prey Pooling	25416956
Intra	GCC1	Q96CN9	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	GCC1	Q96CN9	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	GCC1	Q96CN9	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	GCC1	Q96CN9	ZC4H2	Homo sapiens	Q9NQZ6	Validated Y2H	32296183
Intra	GCC1	Q96CN9	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Array	32296183
Intra	GCC1	Q96CN9	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	FIGNL1	Homo sapiens	Q6PIW4	Y2H Array	32296183
Intra	GCC1	Q96CN9	FIGNL1	Homo sapiens	Q6PIW4	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	NAB2	Homo sapiens	Q15742	Y2H Array	25416956
Intra	GCC1	Q96CN9	NAB2	Homo sapiens	Q15742	Validated Y2H	25416956
Intra	GCC1	Q96CN9	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	GCC1	Q96CN9	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
Intra	GCC1	Q96CN9	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2z	CMT2Z Charcot-Marie-Tooth Disease Axonal Type 2z Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z Charcot-Marie-Tooth Neuropathy, Type 2z Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z Charcot-Marie-Tooth Neuropathy Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation Charcot-Marie-Tooth Disease 2z Charcot-Marie-Tooth Disease, Type 2z
Phencyclidine Abuse	Pcp Abuse
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05319	GCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GCC1	VGNC	VGNC:41139
Bos taurus	GCC1	VGNC	VGNC:29280
Rattus norvegicus	GCC1	RGD	RGD:2319954
Felis catus	GCC1	VGNC	VGNC:62487
Mus musculus	GCC1	MGD	MGI:1921625
Macaca mulatta	GCC1	VGNC	VGNC:72742
Others	GCC1	NCBI